1QE0,1ADJ,1KMM


Conserved Protein Domain Family
HisRS_anticodon
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cd00859: HisRS_anticodon 
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HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.
Links
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Statistics
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PSSM-Id: 238436
Aligned: 51 rows
Threshold Bit Score: 78.7356
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodon
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Comment:based upon similarity with ProRS anticodon binding domain interaction with tRNA anticodon stem
  • Citation:PMID 9493271
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##                                             #     #       #         #
1QE0_A    329 NLDLFIVTMGd--QADRYAVKLLNHLRHNg------IKADKDYLq---rKIKGQMKQADRLGAKFTIVIGDQELENNKID 397 Staphylococcus aureus
3915061   348 RSKVLIVNLDs--ALQNYYYELATRFRNHdyskvknISCEVYFKnkngkNIKEQIEYALSKEIRFLVFVGQEEYKENKMK 425 Lyme disease spiro...
6226180   326 IKPVFVLPIGk--NNICYALDIVDKLRLQn------IVSIIDPIg----KIAKRIQRVLNEDAKFIIFIGDEEKMNNNLK 393 Rickettsia prowazekii
7674358   345 QAKVLIACMHe--EYFSYANRLAESLRQSg------IFSEVYPEa---qKIKKPFSYANHKGHEFVAVIGEEEFKSETLS 413 Helicobacter pylor...
NP_353700 379 LAPVLITVMDgdvESMGRYQRFTQALRAEg------IRAEMYQGnw--kKFGNQLKYADRLGSPIAIIQGGDERAEGVVQ 450 Agrobacterium tume...
NP_542034 377 VGPVVVLVMDkdtQNLSRYQKMVSDLRKAg------IRAEMYVGg---sGMKAQMKYADRRAAPCVVIQGSQEREAGEVQ 447 Brucella melitensi...
NP_422307 382 RGPVVVITFDq--AHMGEYFSVVGQLRAAg------IAAEVYLGt---sGMKPQMKYADRRGAPAVVMLGGDEIAAGTVT 450 Caulobacter cresce...
NP_360049 349 VKPVFVLPIGk--NNICYALEIVDKLRTEn------IAIIIESLg----KIAKRMQRIFNENAQFIIFIGDEEQANNNLK 416 Rickettsia conorii
NP_299501 367 SVQAMVVLMDe--ATLDDALDIARCLRIGg------INTEVQMEa---kKVSKQFQYASRAGIRFVVLAGDDERARGVVA 435 Xylella fastidiosa...
NP_489052 368 PAQVVVVNMQd--ELMPTYLKVSQQLRQAg------LNVITNFEk---rQLGKQFQAADKQGIRFCVIIGADEAAAQKSS 436 Nostoc sp. PCC 7120

Feature 1      #                                       
1QE0_A    398 VKNMT------------------TGESETIEL-DALVEYFK 419 Staphylococcus aureus
3915061   426 VRDLT------------------KKEELLLSF-EESINLIK 447 Lyme disease spirochete
6226180   394 FKDLK------------------NQKEYIIDF-EKVLELLK 415 Rickettsia prowazekii
7674358   414 LKNMH------------------SGMQLNCLSfLKALEIIG 436 Helicobacter pylori J99
NP_353700 451 IKDLIegkrlsgeiednaswreaRVAQVSVPE-AELVAKVR 490 Agrobacterium tumefaciens str. C58
NP_542034 448 IKDLVegkrlsaeiednvtwresRPAQITVRE-DGLVDAVR 487 Brucella melitensis 16M
NP_422307 451 IKDLDagrmaaegltdnaawkaeRPGQQTIPR-DQLVDAVR 490 Caulobacter crescentus CB15
NP_360049 417 IKDLK------------------KAEEYIVDF-AKALELLK 438 Rickettsia conorii
NP_299501 436 VKDLT------------------REQQFEIPR-EELASTLQ 457 Xylella fastidiosa 9a5c
NP_489052 437 LKDLQ------------------SGEQVEVAL-ADLAEEIK 458 Nostoc sp. PCC 7120

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