1EVH,2JP2,1MKE,1I7A,1I7A,1QC6,1DDV,2IYB,1XOD


Conserved Protein Domain Family
EVH1_family
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cd00837: EVH1_family 
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EVH1 (Drosophila Enabled (Ena)/Vasodilator-stimulated phosphoprotein (VASP) homology 1) domain
The EVH1 domains are part of the PH domain superfamily. EVH1 subfamilies include Enables/VASP, Homer/Vesl, WASP, and Spred. Ligands are known for three of the EVH1 subfamilies, all of which bind proline-rich sequences: the Enabled/VASP family binds to FPPPP peptides, the Homer/Vesl family binds PPxxF peptides, and the WASP family binds LPPPEP peptides. EVH1 has a PH-like fold, despite having minimal sequence similarity to PH or PTB domains.
Links
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Statistics
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PSSM-Id: 269909
Aligned: 9 rows
Threshold Bit Score: 127.963
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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proline-rich
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:proline-rich peptide binding site [polypeptide binding site]
Evidence:
  • Comment:Homer/Vesl family binds PPxxF peptides
  • Structure:1I7A_A; Mouse Vesl2 binds to proline-rich mGluR peptide (TPPSPF)
  • Structure:1DDV_A; Rat Homer binds proline-rich mGluR peptide (TPPSPF), contacts at 4A
  • Citation:PMID 9808459
  • Comment:Enabled/VASP family binds to FPPPP peptides such as vinculin, zyxin and ActA
  • Structure:1QC6_A; Mouse EnaVASP-Like protein EVH1 domain binds ActA peptide EFPPPPT
  • Comment:WASP family binds LPPPEP peptides
  • Structure:1MKE_A; N-WASP bound to minimal proline-rich recognition peptide (PEPPPL) of WIP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #         #                                                           #
1EVH_A      5 SICQARAAVMVYDda-nKKWVPagg-stGFSRVHIYHHTg-----nNTFRVVGRKIqdhQVVINCAIPkgLKYNQAtqtF 77  house mouse
2JP2_A     14 YIVRVKAVVMTRDds-sGGWFPqe--ggGISRVGVCKVMhpegngrSGFLIHGERQkdkLVVLECYVRkdLVYTKAnptF 90  human
1MKE_A     42 TMSSAVVQLYAADr--nCMWSKk-----CSGVACLVKDNp-----qRSYFLRIFDIkdgKLLWEQELYnnFVYNSPrgyF 109 synthetic construct
1I7A_A      5 PIFTTRAHVFQIDpstkKNWVPas---kQAVTVSYFYDVt-----rNSYRIISVDGa--KVIINSTITpnMTFTKTsqkF 74  house mouse
1I7A_D      5 PIFTTRAHVFQIDpstkKNWVPas---kQAVTVSYFYDVt-----rNSYRIISVDGa--KVIINSTITpnMTFTKTsqkF 74  house mouse
1QC6_A      5 SICQARASVXVYDdt-sKKWVPikpgqqGFSRINIYHNTa-----sSTFRVVGVKLqdqQVVINYSIVkgLKYNQAtptF 78  house mouse
1DDV_A      5 PIFSTRAHVFQIDpntkKNWVPts---kHAVTVSYFYDSt-----rNVYRIISLDGs--KAIINSTITpnMTFTKTsqkF 74  Norway rat
2IYB_A      6 SICQARAAVMVYDda-nKKWVPagg-stGFSRVHIYHHTg-----nNTFRVVGRKIqdhQVVINCAIPkgLKYNQAtqtF 78  human
1XOD_A      5 SYARVRAVVMTRDds-sGGWLQlg--ggGLSSVTVSKTLqpgdsggTEFLVHGERLrdkTVVLECVLRrdLVYNKVtptF 81  western clawed frog

Feature 1      #                               
1EVH_A     78 HQWRDAr--QVYGLNFGsKEDANVFASAMMHAL 108 house mouse
2JP2_A     91 HHWKVDn--RKFGLTFQsPADARAFDRGVRKAI 121 human
1MKE_A    110 HTFAGDt--CQVALNFAnEEEAKKFRKAVTDLL 140 synthetic construct
1I7A_A     75 GQWADSranTVFGLGFSsELQLTKFAEKFQEVR 107 house mouse
1I7A_D     75 GQWADSranTVFGLGFSsELQLTKFAEKFQEVR 107 house mouse
1QC6_A     79 HQWRDAr--QVYGLNFAsKEEATTFSNAXLFAL 109 house mouse
1DDV_A     75 GQWADSranTVYGLGFSsEHHLSKFAEKFQEFK 107 Norway rat
2IYB_A     79 HQWRDAr--QVYGLNFGsKEDANVFASAMMHAL 109 human
1XOD_A     82 HHWRIGd--KKFGLTFQsPADARAFDRGIRRAI 112 western clawed frog

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