1I6M,3KT0,2G36,2EL7,2A4M,3JXE,2YY5,2QUH,3HV0,3I05,3FOC


Conserved Protein Domain Family
TrpRS_core

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cd00806: TrpRS_core 
Click on image for an interactive view with Cn3D
catalytic core domain of tryptophanyl-tRNA synthetase
Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding
Statistics
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PSSM-Id: 173903
View PSSM: cd00806
Aligned: 53 rows
Threshold Bit Score: 257.897
Threshold Setting Gi: 25009430
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1I6M_A; Geobacillus stearothermophilus TrpRS binds Trp-AMP, defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #####      # ##  #                  #    #                                    
1I6M_A      3 TIFSGIQpsg-viTIGNYIGaLRQFVELQH--EYNCYFCIVDQHAITvwq--dpHELRQNIRRLAALYLAVGIDpt--qA 75  Geobacillus stearo...
3JXE_A     75 FLYTGRGpsg-pmHIGHIIP-FFATKWLQEkfGVNLYIQITDDEKFLfkenltfDDTKRWAYDNILDIIAVGFDpd--kT 150 Pyrococcus horikoshii
3FOC_A     93 YIYTGRGpssgalHLGHLLP-FIFTKYLQDafKCYVVIQITDDEKFLrnrslsyAEVDSYTRENIKDIIACGFDpd--kT 169 Giardia lamblia AT...
Q8ZTU5     74 ALYTGRGpsg-pvHIGHMVPwILLKWFSDKf-GLEVYFQITDDEKFYddpemklEEATNWAYENALDVIALGFSpe--rL 149 Pyrobaculum aeroph...
Q58810     68 AVVSGMMpsg-kmHFGHKMV-VDLLKFYQKy-TDNINIPIADLEAYWarnmsfeTTKELALNEYITNYIALGLDpe--kI 142 Methanocaldococcus...
Q8TYF7     64 SVLSGMMpsg-rmHLGHKTV-VDQLVFYQQemDVKVYVPIADLEAHHarnmdldRAHRIAVEEYVLNYAALGLDldpdrC 141 Methanopyrus kandleri
O28579     65 AVMSGFMpsg-lpHFGHKMT-MDEIVWHQSa-GGKAFVAIADMEAHSvrg-lswEKTRELGMLYIKSIIALGLRe---dA 137 Archaeoglobus fulg...
Q97ZX0     74 FLYTGRApsl-gmHIGHLIP-FIFTKWLQEkfNANLYIEITDDEKYMrnpeftlDQTRSWAYDNILDIIAVGFNp---dK 148 Sulfolobus solfata...
Q8TUA1     67 SVMDGFMpsg-kvHLGHKMV-MDQIVWHQEm-GASAFVGIADREAFSvrgfswqKCREIGVEEYILSLIALGFKp---dG 140 Methanosarcina ace...
NP_586359  82 YLYTGRGpssktmHIGHTIP-FLLCKYMQDafKIRLVIQITDDEKFLwks-mrlEDAMAYGRENIKDIVALGFDp---kL 156 Encephalitozoon cu...
Feature 1         #                                               #   #  #                    
1I6M_A     76 TLFIQSEVp---AHAQAAWMLQCIVYIGELERMtqfkeksagkeavsaGLLTYPPLMAADILLYNt-------------- 138 Geobacillus stearo...
3JXE_A    151 FIFQNSEFt---KIYEMAIPIAKKINFSMAKAVfgfte------qskiGMIFFPAIQIAPTFFERk-------------- 207 Pyrococcus horikoshii
3FOC_A    170 FIFINSQYlslkNRYRFSCLVDRMLPISQLRASfgfsn------danvGYAAFPPKQMLPVYSTYfdglpftrvplpvgt 243 Giardia lamblia AT...
Q8ZTU5    150 HLIIDTKDi--kPLYPIAVRVAKKLTWNTVKATfgftd------stniGLIFYPSLQIAVAFLPTelrr----------- 210 Pyrobaculum aeroph...
Q58810    143 NVYLQSKYq---KVKDLALILSKRTNWSEMKAIygfkg------etniGHVFAPIVQVADILHPQldenls--------- 204 Methanocaldococcus...
Q8TYF7    142 EIYLQSERk---TVQRMALLLAGRLTWNTVKNTygftg------etnmGHAFAPIVQAADILHPQeieg----------- 201 Methanopyrus kandleri
O28579    138 VIYFQSKSs---HVKDLAFELSAEVNFSELRAIygfns------dtslAKMFVTAIQAADILHPQlsdfg---------- 198 Archaeoglobus fulg...
Q97ZX0    149 TFIFQDTEyi-rNMYPITVKIAKKLTFSEVRATfglda------ssniGLIFYPALQIAPTMFEKk-------------- 207 Sulfolobus solfata...
Q8TUA1    141 LIYFQSGCg---SVKDLAFELGAKVNFSELSAIygfsg------etslSHMLSVATQAADILQPQleefg---------- 201 Methanosarcina ace...
NP_586359 157 TYIFSNVEas-hHFEENILKISKTINLNEAIKVfgfdm------ssniGQVGFPAKEIAPCFSSSfrfig---------- 219 Encephalitozoon cu...
Feature 1                                                    # ## ##  #                       
1I6M_A    139 ---------------------------------------------DIVPVGEDQKQHIELTRDLAERFnkry-------- 165 Geobacillus stearo...
3JXE_A    208 --------------------------------------------rCLIPAAIDQDPYWRLQRDFAESLg----------- 232 Pyrococcus horikoshii
3FOC_A    244 gnedaadavstkkaskktpkkdavlspvhvveelfpdskryqkamCLIASGIEQDPYFRLARDLAPRMg----------- 312 Giardia lamblia AT...
Q8ZTU5    211 -----------------------------------------eatpVLIPCAIDQDPYFRLARDIADALg----------- 238 Pyrobaculum aeroph...
Q58810    205 ----------------------------------------pepkpVVVPVGIDQDPHIRLTRDIANRAkef--------- 235 Methanocaldococcus...
Q8TYF7    202 ------------------------------------------phrVLVPVGVDQDPHLRLTRDIAEKEd----------- 228 Methanopyrus kandleri
O28579    199 -----------------------------------------gpkpVVVPVGADQDPHMRLTRDLAARIsifsfepveggv 237 Archaeoglobus fulg...
Q97ZX0    208 --------------------------------------------rCLIPAGIDQDPYWRLQRDIAESLg----------- 232 Sulfolobus solfata...
Q8TUA1    202 -----------------------------------------gpkpVVVPVGPDQDPHLRLTRGLAGKMnmfrveeredvk 240 Methanosarcina ace...
NP_586359 220 -----------------------------------------kgamCLVPAAVDQDPFFRLARDKAKALg----------- 247 Encephalitozoon cu...
Feature 1                                                                                #    
1I6M_A    166 -----------------------------------------------------------gelfTIPEARipkvgaRIMSL 186 Geobacillus stearo...
3JXE_A    233 --------------------------------------------------------------yYKTAALhs---kFVPSL 247 Pyrococcus horikoshii
3FOC_A    313 --------------------------------------------------------------hPKNAYLlg---kFLPGL 327 Giardia lamblia AT...
Q8ZTU5    239 --------------------------------------------------------------yPKPSTLys---kFIMAL 253 Pyrobaculum aeroph...
Q58810    236 -------------------------------------------------------------kfIPPSSTyh---rFMTGL 251 Methanocaldococcus...
Q8TYF7    229 --------------------------------------------------------------lIKPASTyh---rFMTGL 243 Methanopyrus kandleri
O28579    238 rvrsrkgaeylsslrdlefdk----------kiyeehmdifgeaeeieravrkieveiggfafIPPSSTyh---rFTTGL 304 Archaeoglobus fulg...
Q97ZX0    233 --------------------------------------------------------------yYKAAQIhs---kFLPPL 247 Sulfolobus solfata...
Q8TUA1    241 tgrkylsvrgktaqkealqelkkripgkvklyeehidvleypdlagleklvrevtvefggyafIPPASTyh---rFMSGL 317 Methanosarcina ace...
NP_586359 248 --------------------------------------------------------------eKKPSSIyv---sLLPDL 262 Encephalitozoon cu...
Feature 1          ## #                                                                       
1I6M_A    187 VDptkKMSKSDpnpkAYITLLDDAKTIEKKIKsavtdsegt---irydkeakPGISNLLNIYSTLsgqsieele------ 257 Geobacillus stearo...
3JXE_A    248 TSlsgKMSASKp--eTAIYLTDSPEDVEKKVWkftltggrptlkeqrekggePEKCVVFKWLEIFfeeddkklker---y 322 Pyrococcus horikoshii
3FOC_A    328 QGsgtKMSASDp--nSAIYLTDTPAQIKNKINryafsggrdteeehrafgadLSVDVSVRYLEVFmkddaeleklk---- 401 Giardia lamblia AT...
Q8ZTU5    254 TGe-sKMSASNp--dSAIYTLDDEKTVRRKVMnaftggrpt--aeeqrkyggNPEVCPVFHYHMLfdpddasveki---r 325 Pyrobaculum aeroph...
Q58810    252 LGg--KMSSSKp--eTAIFLTDDEKTVKKKIFsaktggretl-eehkkyggvPEECVVYELFLYHlilddkelaei---y 323 Methanocaldococcus...
Q8TYF7    244 TGg--KMSSSKp--nTAIFLTDDPETAKEKVWnaktgggatl-eehrehggnPDECVVYELMVYHladriggdeklreir 318 Methanopyrus kandleri
O28579    305 TGg--KMSSSKp--eSYISLLDPPEEGAKKVMkaftggrata-eeqrrlggePDRCVVFELYSFHlidsdeelnqi---e 376 Archaeoglobus fulg...
Q97ZX0    248 TGpegKMSSSNp--eTAIYLVDDPKTVERKIMkyafsggqptielhrkyggnPEIDVPFQWLYYFfeeddnrikei---e 322 Sulfolobus solfata...
Q8TUA1    318 QGg--KMSSSIp--eSQIALTDSPKEGAKKVKraktggcvtl-eeqkklggkPEECSVFELMLFHliasdeellei---k 389 Methanosarcina ace...
NP_586359 263 KGvnrKMSASDp--nSSIYLDDAQDTIRKKIIayaysggrkt-leehrekggDIDVDVPFEYLKYfldddqeleky---r 336 Encephalitozoon cu...
Feature 1                             
1I6M_A    258 --rqyegkgyGVFKADLAQVVIET 279 Geobacillus stearothermophilus
3JXE_A    323 yackngeltcGECKRYLISKIQEF 346 Pyrococcus horikoshii
3FOC_A    402 adyktgklltGEVKATLIGILQGL 425 Giardia lamblia ATCC 50803
Q8ZTU5    326 qdcksgallcGECKLKLHEKITKF 349 Pyrobaculum aerophilum
Q58810    324 qkcrsgeltcGKCKKMAYERVVEF 347 Methanocaldococcus jannaschii
Q8TYF7    319 kkcregdiicGECKRMVGEALAEI 342 Methanopyrus kandleri
O28579    377 aecregrllcGKCKKMAAELVKSF 400 Archaeoglobus fulgidus
Q97ZX0    323 eeyrsgkmltGELKQILIDKLNNF 346 Sulfolobus solfataricus
Q8TUA1    390 qecisgtrmcGSCKQLAAEKMQEF 413 Methanosarcina acetivorans
NP_586359 337 sgyikgeitsKEMKEKCVVVIQEF 360 Encephalitozoon cuniculi GB-M1

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