Conserved Protein Domain Family
INT_RitB_C_like
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cd00797: INT_RitB_C_like 
C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio.
Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.
Links
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Statistics
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PSSM-Id: 271178
Aligned: 14 rows
Threshold Bit Score: 236.434
Created: 18-Mar-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:The catalytic residue tyrosine is surrounded by three basic residues at the active site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               #                                     
P55635    105 YSKEDIQRLLSAALEmpcrytrckLRPWTYYCLFGLLSVSGLRLGEARNLKLADVDFdaAVLTIRgTKFGKSRLVPMHAS 184 Rhizobium sp. NGR234
P55638    109 LSEAELASLIDACARisp---gipLRGLTMATLIGLLASSGLRSGEVVRLDRSDVDLtnGVLLVRkTKFRKDRLVPVHAT 185 Rhizobium sp. NGR234
CAD31629  102 YNDAEITALLAAALSlpp---anaLRRWTYHCLFGLIAVAGLRHSEALDLRRDDVDLdqGILTIReTKFGKSRLVPLHAT 178 Mesorhizobium loti
NP_942769 105 YTEQEIDLLMTRAAQlrs---rtgMRALTYSTLIGLLVATGLRPGEALRLDRSDVDLvsGILSIReSKFGKSRFVPVAES 181 Ralstonia eutropha
NP_085858 114 FSREEVLRILAAASAheg----hfIWASMLRRLVLMLYCTGIRLGEATRLKMEDVDLerGTLLIR-NSKRRTRIVPIRED 188 Mesorhizobium loti
NP_106769 111 LEPAQVSRMLAAADGlapt-tnspLLPAVMRLATIILYTAGLRRGELARLTLDDVEPqsGLLRIRqSKFHKSRLVPLSPD 189 Mesorhizobium loti
ACB74502  111 YTVAEVRRIMAAAPPaers--pdpLRPVVFATLVGFLYATGLRVGEAVKLNLADVDLsrRLLLIRqTKFGKTRYVPLAPC 188 Opitutus terrae PB...
NP_106530 106 YRDEEITRLIDAAKLlps---tvgLRPQTYATLFGLYAATGLRCNEPLRLDRGDTDLvdGILTVRdTKFGKSRYVPLHPS 182 Mesorhizobium loti
NP_085851 108 YTELEISELLAAARElp-----gtLPSATYETLFGLLASTGLRLSEALHLRCSDVDLrsGRLIVRqGKLGKSRLVPLHAT 182 Mesorhizobium loti
NP_436129 102 YSPEEIRRLIDAARRlgp---ddsIRSLTYATMFGLIAATGMRVSEAIAIRLHDVTDd-GLIIAQ-TKFKKSRLLPLHTT 176 Sinorhizobium meli...

Feature 1                                                                          #  ##      
P55635    185 TCAVLRDYLKRRrqhcaaq--aaspylFTSQLGNRLDvgdihrTFYALSRQIGLRga----tDSHGPRLHDMRHVFATNT 258 Rhizobium sp. NGR234
P55638    186 TQTALCRYARERdaafps---pkdqafFLSSRGNRLSatglqcGFAQVRKFAGLD-------DGKTLRPHDLRHRFAVTR 255 Rhizobium sp. NGR234
CAD31629  179 TVAVLSDYAARRdvhlva---prspyfFVAEQGGRLLhqyvhrVFWQLSRQIGLRqr----gQRNGPRIHDLRHRFAVQA 251 Mesorhizobium loti
NP_942769 182 TRVALEHYAKKRdqlcps---rlseafLVSERGKRLKagtarsMFVRMSRAVGLRsatedgrDGYGPRLQDFRHSFATGR 258 Ralstonia eutropha
NP_085858 189 LIGELRLYLHDRrrllldlhrpdhgafFIRQKGGPLDisgasvAIREILRRLDIKpa----rGRVGARPYEFRHAFAVHR 264 Mesorhizobium loti
NP_106769 190 AAGALRTYLHLRlapsfnadpssallcCGRAGRRGYTgaglgqAINRLFVTADVRd-----sEGRLPRVHDIRHSFGVQA 264 Mesorhizobium loti
ACB74502  189 TTKQLAAYVAQRraarfsq--eptapfFPSSLGGRYHvpsfttVFLQVLRRLGLRgp----pGQRGPRIHDLRHSFAVSR 262 Opitutus terrae PB...
NP_106530 183 TQDALKIYAASRdrscpn---pvsssfFLSERGTRLTewavrwTFVKLSREVGLRga----nDSRGPRLHDLRHRLAVTT 255 Mesorhizobium loti
NP_085851 183 VCEVLSRYLGVRqqlplt----sesyfFVSQTGGLLPrrtvegVFIRLRTKLGWApr----gNWRAPRIHDLRHTFICRR 254 Mesorhizobium loti
NP_436129 177 TRRALDGYLATRlkaas-----qsdalFISHQGTPLAyptvitVFLQIIRSIGLRga----pGSRGPRIHDLRHTFAVRS 247 Sinorhizobium meli...

Feature 1                                     #               
P55635    259 LVRWYEAEQDperlLPILSTYLGHVHVADTQWYLTGsPELMKEAMRRL 306 Rhizobium sp. NGR234
P55638    256 MSLWHQQRANvqalLPVLATYLGHANYSDTAYYLTGsVDLLAMAAERA 303 Rhizobium sp. NGR234
CAD31629  252 LTNWYRAGEDvereLPVLSTFLGHANVRDTYWYLSAaPELMTHAARLL 299 Mesorhizobium loti
NP_942769 259 LVEWYRAGLDvsreLPKLAAYLGHVNIGLTYWYIEAvPELLELAAAYL 306 Ralstonia eutropha
NP_085858 265 LTAWAEEGADihvkLPFLSAYLGHQNILGTEVYLKAtPQLLELASTRF 312 Mesorhizobium loti
NP_106769 265 LIRWYRAGADvqscLPSLAIYMGHVSVVSTAHYLHFvPTMRELASSRF 312 Mesorhizobium loti
ACB74502  263 LMAWHKSGDNlfakLPLLSTYLGHSTVTGTEIYLHAtAELMESVGQRF 310 Opitutus terrae PB90-1
NP_106530 256 LLRWYRNGVDverhLPELATYLGHAHITDTYWYLTAtPELLQQALLRA 303 Mesorhizobium loti
NP_085851 255 VTQWHKEGADidnaMLYVSTYVGHVAVTYTYWYLTGiPELMTVVGQRF 302 Mesorhizobium loti
NP_436129 248 LEHCAHDSQAvarhITALSTYLGHAHVTDTYWYLQStPELMAHMSEAG 295 Sinorhizobium meliloti

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