1JEY,1JEQ


Conserved Protein Domain Family
KU70
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cd00788: KU70 
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Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in the nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.
Links
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Statistics
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PSSM-Id: 238407
Aligned: 37 rows
Threshold Bit Score: 175.546
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingheterodimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1JEY; Ku heterodimer binds DNA; defined at 4A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #####                                                 #    #   #                
1JEY_A    254 RALSRLKLKLNKd---------------------------------IVISVGIYNl--VQKALKP--------------- 283 human
XP_710203 330 RIQFTCDLILSDngki---------------------------gggFGCTVKGYMl--YSHEKIN--------------- 365 Candida albicans S...
CAG89149  285 RILFSCDLILGDgegv---------------------------sgnFGCSVKGYTi--YNHEKLK--------------- 320 Debaryomyces hanse...
CAA49840  265 RIMFQCPLILDEkt-------------------------------nFIVGVKGYTm--YTHEKAG--------------- 296 baker's yeast
NP_982830 247 RAYFSCPLVINKta-------------------------------dLVVSVAGYVa--TTHERPG--------------- 278 Eremothecium gossypii
AAS53814  264 RLRYSCPLFLNEeq-------------------------------gLVVSVKGYAa--TTYERPG--------------- 295 Ashbya gossypii AT...
CAH01326  267 RIKFRCPLMLDEra-------------------------------dLVVSVNGYTi--VSHEIPG--------------- 298 Kluyveromyces lact...
NP_499438 241 RSHATLTVNVGPg---------------------------------VTFDVSVFS---MVMEAKPld------------- 271 nematode
CAG60303  274 RVVFQCPLVLDEgt-------------------------------nFVISIKGYSi--FNHEKGS--------------- 305 Candida glabrata C...
XP_975296 139 FYKRTIIFITNDdnpvrgdknqrfaalneaknfesnditfelvtmkPNFDYKIFYnelFSIIKSPpvetvvededglfek 218 red flour beetle

Feature 1             #                                              #                        
1JEY_A    284 -------PPIKLYr--------------eTNEP------------------VKTKTRTFNts-----------tGGLLLP 313 human
XP_710203 366 -------RNELLLy---------------TRSEtl--------------krVFSSSKLMQn-------------GKAIEI 396 Candida albicans S...
CAG89149  321 -------KFNKIYn---------------SGEElk---------------iVHTRSKILN--------------DRTGEK 349 Debaryomyces hanse...
CAA49840  297 -------VRYKLVy---------------EHEDir--------------qeAYSKRKFLN--------------PITGED 326 baker's yeast
NP_982830 279 -------TRYKYIv---------------KHDGrt--------------ksVHQCRKYKTvd-----------nEKYIRD 311 Eremothecium gossypii
AAS53814  296 -------ARYRMVy---------------QHEDvq--------------reAFSHRRYLD--------------PDTGEE 325 Ashbya gossypii AT...
CAH01326  299 -------SKYKLVy--------------aNGSVrr---------------eAYSHREYLD--------------AETGEA 328 Kluyveromyces lact...
NP_499438 272 -----hsQKYTRDteekivktsgyvkkesKMELesteietqdsvldetqkmLIRCKNFFCcen--------sekNEFLED 338 nematode
CAG60303  306 -------VRYKLVy---------------ENQEir--------------keAFSKRKFIN--------------PKTGED 335 Candida glabrata C...
XP_975296 219 lsssvvrRFYQRRllf----------fpfANDQtr---------------fLKIRQKSFVqeerlynnasvsesGKLLKK 273 red flour beetle

Feature 1                                                                                     
1JEY_A    314 -----------------SDTKRSQIYG--------SRQIILEK------------------------------------- 331 human
XP_710203 397 akdtgks---yqdrkeeAGIRKGFEIGg------gQDIIILNKqqlefltnysfdhrlkdsddednedgndsletdisdd 467 Candida albicans S...
CAG89149  350 vevetkgnqsvternedANIRKGFPIGndhvlylnSKQINFLKny----------------------------------- 394 Debaryomyces hanse...
CAA49840  327 v---------------tGKTVKVYPYG--------DLDINLSD------------------------------------- 346 baker's yeast
NP_982830 312 -----------------ADRSSVYWIG--------GAGIEVTD------------------------------------- 329 Eremothecium gossypii
AAS53814  326 a---------------tEDLCKVYQIG--------DDCLDLPDd------------------------------------ 346 Ashbya gossypii AT...
CAH01326  329 vd--------------nSQLSKVYTFG--------DEIIELTE------------------------------------- 349 Kluyveromyces lact...
NP_499438 339 sir------------nrRDLKKSIEIG--------GEKIILDG------------------------------------- 361 nematode
CAG60303  336 v---------------sKQTVKIIPYG--------EKEIEMEDk------------------------------------ 356 Candida glabrata C...
XP_975296 274 vsk------------tvNDSIETYKLDy------eLGSLEFSV------------------------------------- 298 red flour beetle

Feature 1                      #                                                              
1JEY_A    332 -----------EETEELK------------------------RFDDPGLMLMGFKPLV-LLKKHHYLrpSLFVYPEesl- 374 human
XP_710203 468 ddeeggaggtgGETKPVS------------------------FSKPPYLKLIGFRDIS-HFSPVYSCgaPIFVTPDvdng 522 Candida albicans S...
CAG89149  395 ---------afDHNSDNRaggnsededddefdnqnedlddhgFSKPPYLKLLGFRSLS-TYQPHYNSsaPIFVTPDmndg 464 Debaryomyces hanse...
CAA49840  347 -----------SQDQIVMea---------------------yTQKDAFLKIIGFRSSSkSIHYFNNIdkSSFIVPDeak- 393 baker's yeast
NP_982830 330 -----------AELRKMTrg---------------------cSKYESFLEILGFRAINtAAPYYSNIgrAYYILPRelp- 376 Eremothecium gossypii
AAS53814  347 ----------lENLITNFa----------------------aPTSDSFLRMLGSRTAVaVLPYYNNIhhVTFLVPDdsv- 393 Ashbya gossypii AT...
CAH01326  350 -----------DENLKIQsg---------------------ySEHESFLKLIGFRSTEqCLHYYDNIdvPAFVVPNeed- 396 Kluyveromyces lact...
NP_499438 362 -----------DQYEYMN------------------------EVNSKGVDFVGFCSMS-RVDRETSVvsSKIIQPNdqt- 404 nematode
CAG60303  357 ----------nIANALNVy-----------------------GNTSASLTVIGFLNEDnSLVFYNNIdkTLFITPDenv- 402 Candida glabrata C...
XP_975296 299 -----------SERFKIRn-----------------------TDLPIGYTLVQVSDRV-TDVGIVLTn-PVIIEVDp--- 339 red flour beetle

Feature 1                                          #                                          
1JEY_A    375 ---------viGSSTLFSALLIKCLEKEVAALCRYTPRrnipPYFVALVPQEEelddqk--------------------- 424 human
XP_710203 523 missavtggftNSFKTFASLYRSCVKLNQYAIVLGCTRsnsrPRLYALYPTHTtnssknplpknld-------------- 588 Candida albicans S...
CAG89149  465 lktasaeggykNSFKTFSSLYQSCIKLQKYGVLFGCLKknsmPNLYALYPTKAtnsnks--------------------- 523 Debaryomyces hanse...
CAA49840  394 ---------yeGSIRTLASLLKILRKKDKIAILWGKLKsnshPSLYTLSPSSVkd------------------------- 439 baker's yeast
NP_982830 377 ---------fsGSAKVLASLNRSMFEKGKAAIVWGQLKagfhPTLFALIPSDGe-------------------------- 421 Eremothecium gossypii
AAS53814  394 ---------yaGSAAVLASLHRTLRASQRAVVLYGKLRatslPALYALAPAAApl------------------------- 439 Ashbya gossypii AT...
CAH01326  397 ---------yaGSIKTLASLYRTMLFKKKSAMVWGKLRpnspPSMFVLTPSSKkd------------------------- 442 Kluyveromyces lact...
NP_499438 405 ---------tlGSTAIYRTFLDRCWARQQAIVCKYQSRskqkMRLMALVPFKKdmtliekrhengeddddmedkkpdllr 475 nematode
CAG60303  403 ---------ieGSFTAFASLFRTLKKLKKVGVVWGSTKsnssPSLYLLWPSKDdd------------------------- 448 Candida glabrata C...
XP_975296 340 ----------kEELDLFASFWQYCVEKNKVLVCFRKLKkldkICFVEFIPKFMnn------------------------- 384 red flour beetle

Feature 1                                                                                     
1JEY_A    425 ----------iqvtpPGFQLVFLPFADDKRK-MPFTEK----------IMATPEQVGKMKAIVEKLRf---tYRSDSFEN 480 human
XP_710203 589 --devdnddnqdefpQGFLLIKLPWLEDVRAlPGEYIKntq----reeIHNDDTLIDNFKQLLPKFEls--hYDPREFPN 660 Candida albicans S...
CAG89149  524 ----------glnfpEGFFLIRLPWLDDVRSlPEYSFLnnvnlnelsgESVPPEILLNFKHIISQFFlr--eYRPLDFPN 591 Debaryomyces hanse...
CAA49840  440 -------------ynEGFYLYRVPFLDEIRKfPSLLSYddg-----seHKLDYDNMKKVTQSIMGYFnlrdgYNPSDFKN 501 baker's yeast
NP_982830 422 --------------tCALRLVRIPFIEEVRCfPTLDGEdr------lfHTREYELVKTVSQNLIRHFslrtsYRPSDIRN 481 Eremothecium gossypii
AAS53814  440 -------------pdAVFILARLPFQEEVRKfPALSPPqa------slASPDYAVLQKITSRIIDLLvlsspYAPADFKN 500 Ashbya gossypii AT...
CAH01326  443 -------------ynQGFYLYKVPFMEEVRKlPDFLNHsa------liESDDYKVMSKVTETLINFFnlkngYRPSDFHN 503 Kluyveromyces lact...
NP_499438 476 leqqraqadssewlhEGFMLVGQPFREELRDdFKRFEEqqn----vltEPSTEEQVNTMKQFVKRLTm---sYNPSFYEN 548 nematode
CAG60303  449 -------------nnQGFYLTKVPFIDEIRKyPTLSNIni------neEWEEYKNVKELTQGIISHFnlksgYHAEEFRN 509 Candida glabrata C...
XP_975296 385 --------------sRVFVAKTIPFNDDHQPiPSALASee------pnESFSKKMLQTTNELIDNLTf---dYDPKMFTN 441 red flour beetle

Feature 1                                                                         
1JEY_A    481 PvLQQHFRNLEALALd-LMEPEQAVDl-----------tLPKVEam-------nkRLGSLVDEFKELV 529 human
XP_710203 661 AsLNYFYKVIKHEILqmELKPSQRPLm-----------eNDITMqk-------laQLKNSINNDDTAI 710 Candida albicans SC5314
CAG89149  592 PsINYFYKIINNELLqeELSPESKTVa------------NNDTTtqklielrgylQQEELQTMLKTLN 647 Debaryomyces hansenii CBS767
CAA49840  502 PlLQKHYKVLHDYLLq-IETTFDENE-------------TPNTKkdrmm--reddSLRKLYYIRNKIL 553 baker's yeast
NP_982830 482 PlLRNFYSTLYHEQS--QDAKRKMPElq----------yLPESDstlhkvqlvrdRIENSIIHDEPPI 537 Eremothecium gossypii
AAS53814  501 PvIATHFRLLSDHLF--ETAQDPRTDdtiarllrlrhrvLDDPEs----------RLAKYLRHWNAFY 556 Ashbya gossypii ATCC 10895
CAH01326  504 PaLQKHFKILREYLLqiEVDKSKPEDegd--------etLQKVKqi-------yaRIASSAKSDDVKQ 556 Kluyveromyces lactis NRRL Y-1140
NP_499438 549 PrLLSERSALCLEATg-EELIERRDTl------------EPYYQip--------kRLQRVGTEIEKIV 595 nematode
CAG60303  510 PaLNRHYKLLHDYLLq-VEIPQDDNDirdr------ylrEDDTLlkit---kireRIMKDTTIDDVEK 567 Candida glabrata CBS 138
XP_975296 442 PsLTKKKAYLRSKLL--EEPQEDVEDv------------SLDSAai-------dkRLGDLGASFKMLF 488 red flour beetle

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