1H4S


Conserved Protein Domain Family
ProRS_core
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cd00772: ProRS_core 
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Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs in the core domain.
Links
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Statistics
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PSSM-Id: 238395
Aligned: 2 rows
Threshold Bit Score: 338.189
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1H4S_A; T. thermophilus ProRS bound to an adenylate Prolyl-analog using 3.5A
  • Comment:3' end of tRNA does not enter the active site
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1H4S_A     13 DFSEWYLEVIQKAELADYgpVRGTIVVRPYGYAIWENIQQVLDRMFKETgHQNAYFPLFIPMSFLRKEAEHVEgfspeLA 92  Thermus thermophilus
Q9ZMJ6     17 DAVLKSPKHPGKAGYIYQi-GSGIYNFLPLAKKVLDKIENVTHKRMQEHgAQNILMSFVVLASLWEKSGRLDKyg-keLL 94  Helicobacter pylor...

Feature 1                       # #                            # #       ###  # # #           
1H4S_A     93 VVTHAggeeleePLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEMRt-rPFLRTSEFLWQEGHTAHATREEA 171 Thermus thermophilus
Q9ZMJ6     95 VFKDRkd----nDFVLSPTLEENITEIAANFIKSYKQLPVHLYQIHTKFRDEIRprfGLVRAREFIMKDGYSFHEDAESL 170 Helicobacter pylor...

Feature 1                                                                                     
1H4S_A    172 EEEVRRMLSIYARLAREyaaiPVIEGLKTEKekfaGAVYTTTIEALMK-------------------------------- 219 Thermus thermophilus
Q9ZMJ6    171 DKEFLNTQSAYKEILSDlg-lDFRIVEADSGa--iGGSKSREFVVLTEcgedtivvcqncdyaanieiakrskrteplms 247 Helicobacter pylor...

Feature 1                                                                                     
1H4S_A        --------------------------------------------------------------------------------     Thermus thermophilus
Q9ZMJ6    248 psalakfptpnttsapsvaeffktepyfvlkalvnkvihkdketlacffvrgddnleetkalntlnllganalelreane 327 Helicobacter pylor...

Feature 1                                                                                     
1H4S_A    220 -------------------------------------------------------------------------------D 220 Thermus thermophilus
Q9ZMJ6    328 edlnkagliagfigpyglkkhvcyiifdedlkegdclivganekdfhavgvdlkgfenlvyadivqvkesdccpncqgaL 407 Helicobacter pylor...

Feature 1         # ## #                             ### #  #        
1H4S_A    221 GKALQAGTSHYLGENFARAFd--IKFQDRdlqVKYVHTTSWGLSw-RFIGAIIMT 272 Thermus thermophilus
Q9ZMJ6    408 KYHKSLEVGHIFKLGQSYAKslkASFLDKngkERFFEMGCYGIGisRLLSVILEQ 462 Helicobacter pylori J99

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