1SES,1SER


Conserved Protein Domain Family
SerRS_core
?
cd00770: SerRS_core 
Click on image for an interactive view with Cn3D
Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs in the core domain. SerRS synthetase is a homodimer.
Links
?
Statistics
?
PSSM-Id: 238393
Aligned: 42 rows
Threshold Bit Score: 406.946
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1SES_A; T. thermophilus SerRS bound to Seryl-hydroxamate-AMP using 3.5A
  • Structure:1SER_A; T. thermophilus SerRS bound to 3' end of tRNA using 3.5A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                      #              
1SES_A    116 ANREIKRVGgppef-----------------------sfpplDHVALMEKNgww--epRISQVSGSRSYALKGDLALYEL 170 Thermus thermophilus
Q9YAG3    124 ATRPIEFWGkpkvwkghvdafreqteaygfkvdheviewrprGHADMMEEVlklgdtlRAARVAGSRFYYLFEDLVFLDL 203 Aeropyrum pernix
Q8ZTP4    120 DSIPVRHWGvvkttkdvvdkld-------kgvdylvvekapvGHADMAEVVlkmadtlKAGEVAGSRFYYLFDDLVWLDF 192 Pyrobaculum aeroph...
Q9HKX5    120 NNQLVRYVGhakvfrddieefkkn---sgnsqdyevlderpkSHVDLGLDLnvi-dleSAARISGSRFYFIKNRLLKLEM 195 Thermoplasma acido...
T03949    167 SSVLRKEVGsqrsf-----------------------nfaikDHLQLGKELdlf-dfdAAAEVSGSKFYYLKNEAVLLEM 222 Zea mays
O83653    118 DNLEIKRCGvppcf-----------------------sfsprDHVELARLLdiv-dfeAGKKVSGIKFYYLKREGVLLEQ 173 Treponema pallidum
Q9NP81    185 QARVLHMVGdkpvf-----------------------sfqprGHLEIGEKLdii-rqkRLSHVSGHRSYYLRGAGALLQH 240 human
O51244    118 DNFEIKRVGvvpqf-----------------------dfkpkDHLELGRDLdll-dfdRAREISGSKFYYLKNEAVFLEI 173 Lyme disease spiro...
AAH55610  185 QARVVEVVGekref-----------------------dfkpkGHLQIGESLdii-rqrRLSHVSGHRSYYLRGAGAQLQF 240 zebrafish
AAF55175  100 PRELAQYVHrqltp-----------------------qsrlkEFSELARALnly-rmdHLGNYTGHKSYYLTGQLATLEQ 155 fruit fly

Feature 1                                                               # #                   
1SES_A    171 ALLRFAMDFMARRgFLPMTLPSYAREKAFLGTGHFp-AYRDQVWAIAe---TDLYLTGTAEVVLNALHSGEILPYeaLPL 246 Thermus thermophilus
Q9YAG3    204 ALLMYAIDFMTSKgYVLVLPPYMLRYNVMSRVIDLe-TFKDAIYEIAg---EDLYLIATAEHPLAALYYNSEIYDedLPL 279 Aeropyrum pernix
Q8ZTP4    193 ALAMYALDYLAQKgFRPVIPPYMLKYDLIRRVLDFd-TFKDAIYKIDg---EDLYLIATAEHGIAAYLYKRELLEeeLPQ 268 Pyrobaculum aeroph...
Q9HKX5    196 ALENYAVDFLSQRgFSIVEPPYMLNLESMRGATDLe-TFKDTLYKIEg---EDLYLIATSEHSIAAMLSNQFLEEkdLPL 271 Thermoplasma acido...
T03949    223 ALVIWAISEVSKKgFTPLITPEIVRSSVVEKCGFSk-GKNTQVYSIEd---SDQCLIGTAEIPVGGIHMDSILAEsaLPL 298 Zea mays
O83653    174 ALIMFGLQFLQERgFVPFLTPDIAREGMVCGLGFNprGSGSNIYRIEg---EHRCLVATAEITLGAYHAGEVLEErsLPR 250 Treponema pallidum
Q9NP81    241 GLVNFTFNKLLRRgFTPMTVPDLLRGAVFEGCGMTpnANPSQIYNIDparfKDLNLAGTAEVGLAGYFMDHTVAFrdLPV 320 human
O51244    174 ALINFSLNKLRDKgFDVFITPDVAREFIVDGIGFNprGNESNIYKIEd---TDKYLVGTSEITLGGYYYNKIIDLt-LPI 249 Lyme disease spiro...
AAH55610  241 ALQNFAMDLLQKRgFIPMVVPDILKSVVFEGCGMQphAQKSQVYSLNpkrsPDLNLAGTGKVGVAGYFMDHAVNLkdLPV 320 zebrafish
AAF55175  156 AIIQYALQAVTEHgFKLISVPDILPKEVIESCGMRteGERTQVYKLD----TGECLSGTSEMALAGFFANKLLSEdqLPL 231 fruit fly

Feature 1              # #     #  #  # #  # # #                                               
1SES_A    247 RYAGYAPAFRSEagsfgKDVRGLMRVHQFHKVEQYVLTEas-lEASDRAFQELLENAEEILRLLelPYRLVEVATgdmgp 325 Thermus thermophilus
Q9YAG3    280 KLVGVSPCFRKEagagnRDLKGIFRVHQFHKVEQFVYSLp---EESSKLHEELISNAKEIFKGLeiPFRVVNIASgdlga 356 Aeropyrum pernix
Q8ZTP4    269 LYVGWSPCFRKEagagsRDIKGIFRVHIFHKVEQFVFSLp---EDSWKWHEEITKNTEELIRGLglPYRVVNICAhdlga 345 Pyrobaculum aeroph...
Q9HKX5    272 RVAGISACFRREagahgKDTKGIFRVHQFNKIEQFVFCKp---EDSWDFLEEILGNAEAIYRSLgiPYRVVNVCSgelgr 348 Thermoplasma acido...
T03949    299 KYVAYSHCFRTEagaagAATRGLYRVHQFSKVEMFIFCRp---EESGKWHEELITIEEDLYASLglHFKTLDMATgdlga 375 Zea mays
O83653    251 LYAGLSHCFRKEagaagQFSRGLYRVHQFTKLEMFAYCTp---SDSECLHERLRSLEEEIFTALeiPFRVVEVCAgdlga 327 Treponema pallidum
Q9NP81    321 RMVCSSTCYRAEtn-tgQEPRGLYRVHHFTKVEMFGVTGpg-lEQSSQLLEEFLSLQMEILTELglHFRVLDMPTqelgl 398 human
O51244    250 RMAGFSHCFRKEagaygQLSKGLYRVHQFSKVEMFCFCKa---EESGVIHDEFLSIQEQIFTELeiPYRVLNICSfdlgs 326 Lyme disease spiro...
AAH55610  321 RTVCSSTCYRAEtd-tgRETWGLYRVHHFTKIEMLGVSAnetgEESSQLLDQFVTLQKEIFSSLklHYRVLDMPTqelgp 399 zebrafish
AAF55175  232 KVTAVSRCYRAEts-glQEEKGIYRVHQFNKVEMFAICTe---EQSEAELEEFKNIEVDLFRRLglNFRLLDMPPcelga 307 fruit fly

Feature 1                           ####                                             # #     #
1SES_A    326 gkWRQVDIEVYLPS---EGRYRETHSCSALLDWQARRANLRYRDPe----------------GRVRYAYTLNNTALAtpR 386 Thermus thermophilus
Q9YAG3    357 caVKKYDLEAWMPA---QGKYREMVSASNCTDWQAYRLGIRLVRRk---------------gMERGYVHTLNATAVAstR 418 Aeropyrum pernix
Q8ZTP4    346 paAKKYDIEVWYPS---QGMYRELASCSNVTDWQSYRLGIRVTRKg----------------MKREYVHTLNCTGLAttR 406 Pyrobaculum aeroph...
Q9HKX5    349 laAKKYDIEAWFPA---QGKFREIVSASNDTDYQARSLNIKYRTS-----------------EGNRFVHTLNSTAIAttR 408 Thermoplasma acido...
T03949    376 paYRKFDIEAWMPG---LERYGEISSASNCTDYQSRRLGIRYRPSpseppststkkgkgaasGPTQFVHTLNATAVAvpR 452 Zea mays
O83653    328 paYRKWDLEAWMPGr-qGGSWGEVTSASNCTDYQARRLNVRYKDAe----------------GKKHYVHMLNGTALAisR 390 Treponema pallidum
Q9NP81    399 paYRKFDIEAWMPG---RGRFGEVTSASNCTDFQSRRLHIMFQTEa----------------GELQFAHTVNATACAvpR 459 human
O51244    327 paYKKYDIEAWMPGrdgKGGYGEVTSTSNCTDYQSRRLKIRYKDQd----------------GQNKFAHMVNGTAIAttR 390 Lyme disease spiro...
AAH55610  400 paYRKFDIEAWMPG---RGSFGEISSASNCTDYQSRRLDIRYEGEd----------------GKLQYAHTVNATACAipR 460 zebrafish
AAF55175  308 paYQKYDIEAWMPG---RQMWGEISSCSNCTDYQARRLGIRYRRSa---------------dGQILHAHTINGTATAipR 369 fruit fly

Feature 1                               
1SES_A    387 ILAMLLENHQLQDGRVRvpQALIPYM 412 Thermus thermophilus
Q9YAG3    419 TITAILENFQDEEGVVAipRALRRYL 444 Aeropyrum pernix
Q8ZTP4    407 TITAILENFQREDGAVEipKVLRQYL 432 Pyrobaculum aerophilum
Q9HKX5    409 ILVAIMENFQEGDRIRIp-DVLVPYT 433 Thermoplasma acidophilum
T03949    453 LIVCILENFQQGDGSIVvpEPLRPYM 478 Zea mays
O83653    391 VLIALLENGQDAEGRVRipQALVPFC 416 Treponema pallidum
Q9NP81    460 LLIALLESNQQKDGSVLvpPALQSYL 485 human
O51244    391 VIISILENFQDQKGGVRipKSLVKYT 416 Lyme disease spirochete
AAH55610  461 TIIAILETYQTKKGTVQvpEVLQQYI 486 zebrafish
AAF55175  370 LLIALLESYQKEDGIEIp-AVLRPFM 394 fruit fly

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap