1FRW,2DPW,1QWJ,1VH3,1YP4,1TZF,1JYL,2CU2,2PA4,1LVW,1H5R,1G97,1VPA,1K4V,1GA8,1FGG,1JV1,2ICY,1FO8,1LL2,1FR8,1XHB,3CKJ,2Z86,2Z87,1H7Q


Conserved Protein Domain Family
Glyco_tranf_GTA_type

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cd00761: Glyco_tranf_GTA_type 
Click on image for an interactive view with Cn3D
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold.
Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
Statistics
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PSSM-Id: 132997
View PSSM: cd00761
Aligned: 289 rows
Threshold Bit Score: 30.9374
Threshold Setting Gi: 13096713
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # #                                                 #                        
1FRW_A         9 GVVLAGgkarrmggvdkgllelngkpLWQHVADALMtq-----------lsHVVVNANrhqeiyqasglkv--------- 68  Escherichia coli
YP_062911     45 FFVPCRde----------------aaVIERTVAAARrdf---------pavHVWVVDDhsdddtgriveaiarrds---- 95  Leifsonia xyli ...
CAJ50241     159 VYVPTYnep---------------ldVVRQTVLAAQaldwp------adrlNVYVLDDgrrpefqafceqig-------- 209 Bordetella aviu...
AAY36383     397 LHVPCYnep---------------pdMVKRTLDSLQtldy--------pdfEVLVIDNntqdpaiwkpierycqql---- 449 Pseudomonas syr...
ZP_01048032   51 VIVPAHde----------------sgGIIPTISDIKsqls--------sndRLIVVADnctddtaavaesaga------- 99  Nitrobacter sp....
3CKJ_A        52 VVLPALde----------------edTIGSVIDSISplvd-------glvdELIVLDSgstddteiravaagarv----- 103 Mycobacterium a...
O60762        29 VLLPTYne----------------reNLPLIVWLLVksfse-----sginyEIIIIDDgspdgtrdvaeqlekiy----- 82  human
XP_001639099  47 VVVPSYne----------------eeRLPIMMDETLeyllekkksnpsftsEIIVVDDgskdkttevglryakqc----- 105 starlet sea ane...
NP_927175     42 VQLPVFne----------------lyVCRRLLAATCaldyp------realHIQVLDDstdetvqllaaaieeqrr---- 95  Gloeobacter vio...
YP_547965    162 IIMPICned---------------vrTVFAGLRATCesvamt---ghvknfDVFVLSDsshpaiiraeraawedlrsqla 223 Polaromonas sp....
Feature 1                                                           # #                          
1FRW_A        69 -----------iedsladypgplAGMLSVmqqe----------agewFLFCPCDTpyippdlaa-------rlnhqrkda 120 Escherichia coli
YP_062911     96 ------rvhlvtrrrpeartgkgDALNAAydalnaflpadadreriiVMVLDADGelsaralamma---saevfldpgvg 166 Leifsonia xyli ...
CAJ50241     210 ---------igyltrsdnkhakaGNINAAlart----------qgeyVAIFDCDHvpvrsflqic-----mgwflkdpkl 265 Bordetella aviu...
AAY36383     450 ------gprfrffhvsplpgfkaGALNYLlrhta--------edaevVAVIDADYcvhrqwlkhm------vphftdpkv 509 Pseudomonas syr...
ZP_01048032  100 ---------eviarndlekigkgYALGWGishlrk-------dppdfVVVFDADCriqsdalerlt----dicgklqrpv 159 Nitrobacter sp....
3CKJ_A       104 ------vsreqalpevpirpgkgEALWRSlaas----------rgdiVVFVDSDLinphpmfvpwl----vgplltgdgv 163 Mycobacterium a...
O60762        83 ------gsdrillrprekklglgTAYIHGmkha----------tgnyIIIMDADLshhpkfipef------irkqkegnf 140 human
XP_001639099 106 ------gvssvrvltlaknrgkgGAVRMGvfss----------rgrkILMADADGatkfsdldrldtalndvtaakgvkp 169 starlet sea ane...
NP_927175     96 -----lgfsiehlhrkerhgfkaGALAAAtpla----------ngeyIAIFDADFlpppdwlkra-----lvhfadgrvg 155 Gloeobacter vio...
YP_547965    224 shpeqpqievyyrlrkrrtdrkaGNVADFcrrwg--------kdyryMVVLDADSvmsgdclvamv----klmeanpkag 291 Polaromonas sp....
Feature 1                                                                                        
1FRW_A       121 PVVWVHdger---------------------------------------dhpTIALVNraiepllleylqag-----err 156 Escherichia coli
YP_062911    167 GAQVVVwmknrherrpkpgh------------------gwlgnlfgrflvklQDIEFRtiiaamqslrar---------t 219 Leifsonia xyli ...
CAJ50241     266 AMLQTPhvffspdpfer------------------------nlgtfrnvpneGELFYGvvqdgndlwn------------ 309 Bordetella aviu...
AAY36383     510 AVIQSPqdyrdgh--------------------------------eslfkccCQAEYRgffnigmvirnd---------h 548 Pseudomonas syr...
ZP_01048032  160 QACFLMrspdnspi-------------------------------dhrfaefAFLLRNwirpfglsnln----------- 197 Nitrobacter sp....
3CKJ_A       164 HLVKSFyrrplnvgdagggagatgggrvtelvarpllaalrpelgcilqplgGEYAATrelltsvpfapgygveigllvd 243 Mycobacterium a...
O60762       141 DIVSGTrykgnggvygwdlkrkii----------srganfltqillrpgasdLTGSFRlyrkevlekliek------cvs 204 human
XP_001639099 170 AIVCGSrahlqeeavatrsafrnfl---------mygfhflvwflcvkgikdTQCGFKlftrsaalltfsa------lhv 234 starlet sea ane...
NP_927175    156 LVQTRWghtnpgy---------------------------------slltrlQALGIDghfaveqqarca--------ng 194 Gloeobacter vio...
YP_547965    292 IIQTATqaighv----------------------------------tlharaQQFASRvtgrlftlgmqfw-------qm 330 Polaromonas sp....
Feature 1                     
1FRW_A       157 vmvfmrlaggHAV 169 Escherichia coli
YP_062911    220 gtvglggngqFAR 232 Leifsonia xyli subsp. xyli str. CTCB07
CAJ50241     310 -atffcgscaVIR 321 Bordetella avium 197N
AAY36383     549 daiiqhgtmtLIR 561 Pseudomonas syringae pv. syringae B728a
ZP_01048032  198 cpvqlmgtgmIFP 210 Nitrobacter sp. Nb-311A
3CKJ_A       244 tfdrlgldaiAQV 256 Mycobacterium avium subsp. paratuberculosis K-10
O60762       205 kgyvfqmemiVRA 217 human
XP_001639099 235 erwafdvellYIA 247 starlet sea anemone
NP_927175    195 yyfnfngtagVWR 207 Gloeobacter violaceus PCC 7421
YP_547965    331 geshywghnaIIR 343 Polaromonas sp. JS666

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