1F6Y


Conserved Protein Domain Family
MeTr
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cd00740: MeTr 
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MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent methyltransferases catalyze the transfer of a methyl group via a methyl- cob(III)amide intermediate. These include MeTr, a functional heterodimer, and the folate binding domain of MetH.
Links
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Statistics
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PSSM-Id: 238381
Aligned: 8 rows
Threshold Bit Score: 332.82
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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substrate
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding pocket [chemical binding site]
Evidence:
  • Comment:pterin binding site is highly conserved
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                     # 
1F6Y_A       1 MLIIGERINGMfgdikr-aiqerdPAPVQEWARRQEEGGARALDLNVGpavqDKVSAMEWLVEVTQevs---nlTLCLDS 76   Moorella thermoa...
6681412    198 LFLVGERLNATgskrfremlfardLEGILALAREQVEEGAHALDLSVAwtgrDELEDLRWLLPHLAtal---tvPVMVDS 274  Thermus thermoph...
13638433   350 VLMIGERTNANgskvfreamiaedYQKCLDIAKDQTRGGAHLLDLCVDyvgrNGVADMKALAGRLAtvs---tlPIMLDS 426  Mycobacterium le...
3122399    340 FLIIGERLNASgskkcrdllnaedWDSLVSLAKSQVKEGAQILDVNVDyvgrDGVRDMKELASRLVnnv---tlPLMLDS 416  Synechocystis sp...
400244     356 FVNVGERTNVTgsakfkrlikeekYSEALDVARQQVENGAQIIDINMDegmlDAEAAMVRFLNLIAgepdiarvPIMIDS 435  Escherichia coli
6458693    368 FVNVGERTNVTgspkfskailagdYDAGLKIARQQVTNGAQIVDINFDegmlDGEGAMVKFLNLLAgepdisrvPLMLDS 447  Deinococcus radi...
3122392    360 FVNIGERCNVAgsrrfcnliknenYDTAIDVARVQVDSGAQILDVNMDdgllDGPYAMSKFLRLISsepdvakiPVCIDS 439  Caenorhabditis e...
3978143    359 FVNIGERCNVAgskkfaklimagnYEEALSVAKVQVEMGAQVLDINMDdgmlDGPSAMTKFCNFIAsepdiakvPLCIDS 438  Norway rat

Feature 1                         # #                            #                             
1F6Y_A      77 TNIKAIEAGLKkcknrAMINSTNAer-----eKVEKLFPLAVEHGaALIGLTMNktgipkdsDTRLAFAMELVAAADefg 151  Moorella thermoa...
6681412    275 TSPEAMELALKylpgrVLLNSANLedg---leRFDRVASLAKAHGaALVVLAIDekgmaktrEEKVRVALRMYERLTehh 351  Thermus thermoph...
13638433   427 TEIPVLQAGLEhlggrCVINSVNYedgdgpesRFVKTMELVAEHGaAVVALTIDeqgqartvEKKVEVAERLINDITsnw 506  Mycobacterium le...
3122399    417 TEWQKMEAGLKvaggkCILNSTNYedg---eeRFYKVLEIAKEYGaGIVIGTIDedgmgrtaDKKFEIAKRAYEAAIafg 493  Synechocystis sp...
400244     436 SKWDVIEKGLKciqgkGIVNSISMkeg---vdAFIHHAKLLRRYGaAVVVMAFDeqgqadtrARKIEICRRAYKILTeev 512  Escherichia coli
6458693    448 SKWEILEAGLRrvqgkAVVNSISLkdg---eaRFLERARLLRRYGaAAVVMAFDeqgqadnlARRREILGRAYRLLTeqa 524  Deinococcus radi...
3122392    440 SDFDVIIAGLEstqgkCVVNSISLkeg---eeKFKERARIIKRYGaAVVVMAFDeqgqaaetDPKFEICERSYRILTeev 516  Caenorhabditis e...
3978143    439 SNFAVIEAGLKccqgkCIVNSISLkeg---eeDFLEKARKIKKFGaAVVVMAFDeegqatetDVKVSVCTRAYHLLVekv 515  Norway rat

Feature 1               #                                      #   #                           
1F6Y_A     152 l-pmeDLYIDPLilpan-vaqdhAPEVLKTLQQIKmla--dpaPKTVLGLSNVsqn----cqnRPLINRTFLAMAMACGL 223  Moorella thermoa...
6681412    352 glrpeDLLFDLLtfpitqgdeesRPLAKETLLAIEelrerlpgVGFVLRVSNVsfgl--kpraRRVLNSVFLDEARKRGL 429  Thermus thermoph...
13638433   507 gvdksAILIDCLtftiatgqeesRKDGIETIDAIRelkkrhpaVQTTLGLSNIsfgl--npsaRQVLNSVFLHECQEAGL 584  Mycobacterium le...
3122399    494 i-patEIFFDPLalpistgieedRENGKATVDAIRrirqelpdCHILLGVSNVsfgl--npaaRQVLNSIFLHECMQVGM 570  Synechocystis sp...
400244     513 gfppeDIIFDPNifavatgieehNNYAQDFIGACEdikrelphALISGGVSNVsfsfrgndpvREAIHAVFLYYAIRNGM 592  Escherichia coli
6458693    525 dfppqDIIFDPNvltvatgieehDRYALDFIEATRwikenlpaAKVSGGISNVsfsfrgnnhvREAMHAVFLYHAIRAGL 604  Deinococcus radi...
3122392    517 gfnpnDIIFDANiltiatgmeehSNYGMYFIEAARmirenlpgAHVSGGVSNIsfsfrgmeaiREAMHSVFLFYAIKAGM 596  Caenorhabditis e...
3978143    516 gfnpnDIIFDPNiltigtgmeehNLYAINFIHATRviketlpgVRISGGLSNLsfafrgmdaiREAMHGVFLYHAIKFGM 595  Norway rat

Feature 1         # #              
1F6Y_A     224 MSAIADacdEALIETAATAE 243  Moorella thermoacetica
6681412    430 TAAIVDagkILPISQIPEEA 449  Thermus thermophilus
13638433   585 DSAIVHaskILPINRIPEEQ 604  Mycobacterium leprae
3122399    571 DAAIVSankILPLAKIDPEQ 590  Synechocystis sp. PCC 6803
400244     593 DMGIVNagqLAIYDDLPAEL 612  Escherichia coli
6458693    605 DMGIVNagmLAVYEDIEPEL 624  Deinococcus radiodurans
3122392    597 DMGIVNagaLPVYEDIDKPL 616  Caenorhabditis elegans
3978143    596 DMGIVNagsLPVYDDIHKDL 615  Norway rat

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