1ADJ,1QE0,1B76,1H4S,1QF6,1G5I


Conserved Protein Domain Family
HGTP_anticodon
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cd00738: HGTP_anticodon 
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HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only. This domain is also found in the accessory subunit of mitochondrial polymerase gamma (Pol gamma b).
Links
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Statistics
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PSSM-Id: 238379
Aligned: 7 rows
Threshold Bit Score: 95.9284
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodon
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1QF6_A; E.coli thrRS bound to tRNA anti-codon using 3.5A
  • Structure:1QF6_A; E.coli thrRS bound to tRNA using 3.5A
  • Citation:PMID 9493271
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##                                           #     #       #            
1ADJ_A    328 GPDLYLIPLTe-----EAVAEAFYLAEALRPr--lRAEYALap---rkPAKGLEEALKRGAAFAGFLGEDelr------- 390 Thermus thermophilus
1QE0_A    329 NLDLFIVTMGd-----QADRYAVKLLNHLRHng-iKADKDYlq---rkIKGQMKQADRLGAKFTIVIGDQele------- 392 Staphylococcus aureus
1B76_A    335 PIKVAVIPLVkn--rpEITEYAKRLKARLLAlglgRVLYEDtg----nIGKAYRRHDEVGTPFAVTVDYDtigqskdgtt 408 Thermus thermophilus
1H4S_B    287 PIQVVIVPIYkdesreRVLEAAQGLRQALLAqg-lRVHLDDrdq--htPGYKFHEWELKGVPFRVELGPKdle------- 356 Thermus thermophilus
1QF6_A    539 PVQVVIMNITd-----SQSEYVNELTQKLSNag-iRVKADLrn---ekIGFKIREHTLRRVPYMLVCGDKeve------- 602 Escherichia coli
11134893  470 PYDLHILALNmk--ndGQRELAEKLYADLKAeg-yEVLYDDra---erAGVKFADSDLIGLPIRITVGKRad-------- 535 Bacillus subtilis
1G5I_D    338 PIKVALDVGKgp--tvELRQVCQGLLNELLEng-iSVWPGYsetvhssLEQLHSKYDEMSVLFSVLVTETtle------- 407 house mouse

Feature 1           # #                    
1ADJ_A    391 --agEVTLKRLatGEQVRLSREEVPGYLL 417 Thermus thermophilus
1QE0_A    393 --nnKIDVKNMttGESETIELDALVEYFK 419 Staphylococcus aureus
1B76_A    409 rlkdTVTVRDRdtMEQIRLHVDELEGFLR 437 Thermus thermophilus
1H4S_B    357 --ggQAVLASRl-GGKETLPLAALPEALP 382 Thermus thermophilus
1QF6_A    603 --sgKVAVRTRrgKDLGSMDVNEVIEKLQ 629 Escherichia coli
11134893  536 --egIVEVKIRqtGESTEISVDELSAFIS 562 Bacillus subtilis
1G5I_D    408 --ngLIQLRSRdtTMKEMMHISKLRDFLV 434 house mouse

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