1APX,1JCI


Conserved Protein Domain Family
ascorbate_peroxidase

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cd00691: ascorbate_peroxidase 
Click on image for an interactive view with Cn3D
Ascorbate peroxidases and cytochrome C peroxidases
Ascorbate peroxidases are a subgroup of heme-dependent peroxidases of the plant superfamily that share a heme prosthetic group and catalyze a multistep oxidative reaction involving hydrogen peroxide as the electron acceptor. Along with related catalase-peroxidases, ascorbate peroxidases belong to class I of the plant superfamily. Ascorbate peroxidases are found in the chloroplasts and/or cytosol of algae and plants, where they have been shown to control the concentration of lethal hydrogen peroxide molecules. The yeast cytochrome c peroxidase is a divergent member of the family; it forms a complex with cytochrome c to catalyze the reduction of hydrogen peroxide to water.
Statistics
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PSSM-Id: 173825
View PSSM: cd00691
Aligned: 32 rows
Threshold Bit Score: 362.292
Threshold Setting Gi: 226456969
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ##  #  #                              
1APX_A      4 YPTVSPDY-------QKAIEKAKRKLRGFIA------EKKCAPLILRLAWHSAGTFDSKTKTGGP-FGTIKHqaELAHGA 69  pea
ABQ53875   69 SSPVSCKEaettskgSVNYDKVREAIVKVIEv-----DDNIAPAMLRLAWHSSGSYDKKTNTGGSdGATMRFspEKDYAA 143 Galdieria sulphuraria
Q6URB0     91 VATVEAKTglr--rgKDEYQKVYNRIAETLDkeg-ydDGSLAPVLLRLAWHASGTYSKADGTGGSnFATMRFkpEAEHSA 167 Cryptococcus neofo...
AAW79295    1 KPHVAMDD-------QMYVNAVKSDIRKALVn----qKGNSCPLAVRLAWHASGTYSKHDDTGGSyGATMRFppEKEDGA 69  Isochrysis galbana
CAJ07706   24 AMFVSCASarv-eepPFDIRALRADIEDMISe-----KLELGPSLIRLAWHEAASYDCFKKDGSPnSASMRFkpECLYAG 97  Leishmania major
ACF85410   73 TPKVFNPT-------KDDYQKVYNEIAARLEekddydDGSYGPVLVRLAWHASGTYDKETGTGGSnGATMRFapEADHGA 145 maize
EEC47524    1 MANAHYAD-------EFYDNAARAEVSRAIVn----kKVNVCPFTVRLAWHASGTFDQSDASGGSdGARMRYapELSDGA 69  Phaeodactylum tric...
Q7SDV9     76 TPKVFAPK-------FDDYQAVYNEIASRLEekddydDGSYGPVLVRLAWHASGTYDKETGTGGSnGATMRFapESDHGA 148 Neurospora crassa
Q6BIB1    146 TKSISVDD-------VEYVEKVKHAIKQVLPkpd-ydDGSLGPVILRLAWHCCATYNKFTGNGGSnGSTMRFvpEITDDG 217 Debaryomyces hansenii
EEY57904   54 TDLVNAREk------AVDLDAIKKEIIDIFDe-----DNYMGPTMVRLAWHSSGSYSGKDNSGGStGGTIRFdpEINHGG 122 Phytophthora infes...
Feature 1                                                                       ###           
1APX_A     70 NNGlDIAVRLLEPIKEQFPiVSYADFYQLAGVVAVEITGGPEVPFHPGREDKpepp-----pegrLPDATKG-----SDH 139 pea
ABQ53875  144 NAGlFRARDALEPVKKQFPeITYADLWTLAGAVAVEEMGGPKVAWRPGRRDAvsgqec--ppdgrLPDADKGtlsgtVQH 221 Galdieria sulphuraria
Q6URB0    168 NNGlHVAREHMEKIKQEFPwISYGDLWTLGGVCAIQESGGPTIPWRPGRIDGyaaqv---tpdgrLPDATQA-----QDH 239 Cryptococcus neofo...
AAW79295   70 NAGlDIERDILQEVKRQHPdLSYADIWTLAGAHAIEIAGGPPIEHKLGRTDAqdgsac--pavgrLPDASQG-----AEH 142 Isochrysis galbana
CAJ07706   98 NKGlDIPRKALETLKKKYPqISYADLWVLAAYVAIEYMGGPTIPFCWGRVDAkdgsvc--gpdgrLPDGSKT-----QSH 170 Leishmania major
ACF85410  146 NAGlAAARNFLEPVKEKFPwITYSDLWILAGVCAIQEMLGPAIPYRPGRSDRdvsgc---tpdgrLPDASKR-----SGH 217 maize
EEC47524   70 NAGlALMQDIIKPVKEKFPdMSYADLWTMAGTQAIKLTGGPDIPFNYGRTDDadnnkc--pangrLPDATQG-----AEH 142 Phaeodactylum tric...
Q7SDV9    149 NAGlKAARDFLEPVKAKFPwITYSDLWILGGVCAIQEMLGPQIPYRPGRQDRdaagc---tpdgrLPDASQA-----QDH 220 Neurospora crassa
Q6BIB1    218 NSGlDIARSALEPIKQKFPdITYSDLWTLAGKISIQEMGGPKIPWRCGRVDCiddryv--ppngrLPFAYKN-----ANH 290 Debaryomyces hansenii
EEY57904  123 NAGlHLAVKALEKVKKNHPeITYADLYILAGATMIEEMGGPEIPFRLGRPDAksgkeptqtpddrLPNADMGskdktTQH 202 Phytophthora infes...
Feature 1         #             ## ## #####  ##     #                                         
1APX_A    140 LRDVFGkAMGLSDQDIVALSGGHTIGAAHKERSGFEGPWTSNPLIFDNSYFTELLTGEK-----------------DGLL 202 pea
ABQ53875  222 IRDIFY-RMGFNDQEIVALVGAHAVGHTHKQFSGYDGPWTRAPTTFSNELFRELLENKWtlrkwngp--dmfedptGEII 298 Galdieria sulphuraria
Q6URB0    240 LRFIFN-RMGFNDQEIVALSGAHAMGRCHPNRSGFDGPWTFSPVTFSNQYFALLRDEPWqwkkwtgp-aqfedkktKTLM 317 Cryptococcus neofo...
AAW79295  143 LREVFY-RMGFNDEDIVALSGAHTLGRCHKTRSGFDGPWTHEPLKFDNSYFKNLLDLEWkprqwdgp--lqyedpsHTLM 219 Isochrysis galbana
CAJ07706  171 VREVFR-RLGFNDQETVALIGAHTCGECHIEFSGYHGPWTHDKNGFDNSFFTQLLDEDWvlnpkveq-mqlmdratTKLM 248 Leishmania major
ACF85410  218 LRDIFY-RMGFNDQEIVALSGAHALGRCHTDRSGYEGPWTFSPTVLTNDYFRLLVEEKWqwkkwngp-aqyedkstKSLM 295 maize
EEC47524  143 LRDVFY-RMGFGDKEIVALSGAHTLGSCHRLRSGFDGPWTTNPLKFDNEYFKNLLEIDWkprewegp--lqyqdpsGKLM 219 Phaeodactylum tric...
Q7SDV9    221 LRNIFY-RMGFNDQEIVALSGAHALGRCHADRSGFDGPWTFSPTVLTNDYYKLLLDEKWqwkkwngp-kqyedkktKSLM 298 Neurospora crassa
Q6BIB1    291 IRETFG-RMGFNDRETVSLLGAHGLGRCHKRFSGWEGKWTENPTSFSNDFYKVLLDEEWslgtvpetgkeqyynkdKSLI 369 Debaryomyces hansenii
EEY57904  203 VRDVFY-RMGFNDRDIVALVGAHAIGRCYPTRSGYSGPWTNAEWTFSNEFFRELIENKWtikkwdgp--mqyedptGKLM 279 Phytophthora infes...
Feature 1      # #                           #   #           
1APX_A    203 QLPSDKALLTDSVFRPLVEKYAaDEDVFFADYAEAHLKLSELGFAEA 249 pea
ABQ53875  299 MLPTDMALTWDKEFRKYVETYAaDQDRFFEDFAKAFQKLEELGVKAF 345 Galdieria sulphuraria
Q6URB0    318 MLPTDMALVKDKSFKKYVDIYAdNEEKFFSDFAKAFSKLIELGVPER 364 Cryptococcus neoformans var. grubii
AAW79295  220 MLPTDLALKTDPKFKEYVVAFAkSETVFRSAFKRAYEQLLCLGCPAH 266 Isochrysis galbana
CAJ07706  249 MLPSDVCLLLDPSYRKYVELYAkDNDRFNKDFANAFKKLTELGTRNL 295 Leishmania major
ACF85410  296 MLPSDIALIEDKKFKPWVEKYAkDNDAFFKDFSDVVLRLFELGVPFA 342 maize
EEC47524  220 MLPTDMALIQDEAFLPFVKKYAeDEQAFFADFAEAFAALISKGCPAH 266 Phaeodactylum tricornutum CCAP 1055/1
Q7SDV9    299 MLPADMALIQDKKFKQWVEKYAaDNELFFKDFSNVIVKLFELGVPFA 345 Neurospora crassa
Q6BIB1    370 MLNTDIELIRDPHFLHFVKLYSqHQATFFQDFANAFGKLLELGIERD 416 Debaryomyces hansenii
EEY57904  280 MLPADIVMIQDPEFKKYVELYAkDEELWFKDFSKAFVKLTENGVKFP 326 Phytophthora infestans T30-4

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