Conserved Protein Domain Family
AlaRS_core
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cd00673: AlaRS_core 
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Links
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Statistics
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PSSM-Id: 238360
Aligned: 28 rows
Threshold Bit Score: 221.08
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site
Evidence:
  • Comment:based on conservation within Class II aaRS's.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                        #  #                 #       
Q9ZCA4      6 TEEVRSKFITYFKAn---NHTHVPASSLi---pDNDpslMFVNSGMVQFKNVF-TGQEKRSynKAVTSQKSLRAggkhnd 78   Rickettsia prowaz...
Q8TU79     60 ISEMREYYLSFFEAr---GHTRLDRYPVva-rwRDDi--YLTIASIADFQPFVtSGQVPPPanPLTISQPCIRLndldsv 133  Methanosarcina ac...
Q8TWY1     61 VWEAGEEFFRFFERh---DHEVLDRYPVva-rwRDDi--HLTIASIACFQPWVtSGEVPPPanPLVINQPCIRLndidnv 134  Methanopyrus kand...
O58035     59 LDEMREKFLRFFEKheiyPHGRVKRYPVlp-rwRDDv--LLVGASIMDFQPWViSGEADPPanPLVISQPSIRFtdidnv 135  Pyrococcus horiko...
P96041     62 VKEAREKFLSFFEKr---GHTRIPPKPVla-rwREDl--YLTIASIVDFQPHVtSGLVPPPanPLVVSQPSIRLedidnv 135  Sulfolobus solfat...
Q9Y9X3     46 VGEAREAFLSFFEKh---GHTRVPPRPVva-rwREDl--YLTIASIVVFQPHVtSGLVPPPanPLVISQPSIRLedidnv 119  Aeropyrum pernix
O28029     62 LDEMREYYLNFFERr---GHGRIERYPVva-rwRTDi--YLTIASIADFQPFVtSGVAPPPanPLTISQPCIRLddldsv 135  Archaeoglobus ful...
Q9HJW4     62 LSEMRDAFIKFFEKr---GHKFLKPYPVvp-rwREDv--LLVNASIYDFQPHVtSGIVRPPgnPIVMSQPSIRMndvdlv 135  Thermoplasma acid...
Q57984     59 YKEMVKEFINFFKEh---GHEPIKRAPVtarrwRDDi--LLTIASIAVFQPWItKGIVKPKanPLVIAQPCIRLndidnv 133  Methanocaldococcu...
P47534      5 TDKVRQTWLDYFAKk---DHLVLASKSLi---pINDpslLWINSGVATLKDYF-SARKTPPskRLVNAQICLRVndienv 77   Mycoplasma genita...

Feature 1                  # # ###                                                            
Q9ZCA4     79 lehvgytarhhtFFEMLGNFSFGd--------yFKEQAIYYTWDLLTkefelpkdklyvtiyhtddpaasywkkiaglkd 150  Rickettsia prowaz...
Q8TU79    134 g----rsgrhltNFEMMAHHAFNkrgn---eiyWKEHTLELCDELLTsl------------------------------k 176  Methanosarcina ac...
Q8TWY1    135 g----rtgrhftLFHMGGHHAFNnhphdrrdiyWKEETVRLCYEFTVekl-----------------------------g 181  Methanopyrus kand...
O58035    136 g----itgrhftIFEMMAHHAFNypgk---piyWMDETVELAFEFFTkel-----------------------------k 179  Pyrococcus horiko...
P96041    136 gv---tfgrhltTFEMAAHHAFNypdr---yvyWKDETTAYATEFFTkel-----------------------------g 180  Sulfolobus solfat...
Q9Y9X3    120 gi---tigrhltSFEMAAHHAFNypdr---qvyWKEETVRLAFEFFTqvl-----------------------------g 164  Aeropyrum pernix
O28029    136 g----rtgrhltLFEMMAHHAFNypgk---eiyWKNETVAYCTELLNel------------------------------g 178  Archaeoglobus ful...
Q9HJW4    136 g----itgrhltSFEMLCHDSFNtkdk---tvyWKEETVHYCYDFLTegl-----------------------------g 179  Thermoplasma acid...
Q57984    134 g----rtgrhltCFTMGGHHAFNredd---fkyWQDETVELCFNFFKkl------------------------------g 176  Methanocaldococcu...
P47534     78 g----ftsrhqtLFEMLGNFSIGd--------yFKTEAIDFAFDLLVnyyqldpkrfyitvyed-dettykrwikhkidk 144  Mycoplasma genita...

Feature 1                                                            ##   #                   
Q9ZCA4    151 dRIIRIKTNDNFWSMGDtgpcgPCSEIFFDhgeeiygglp----gtkdencdrfIEIWNMVFMQYeqink---------- 216  Rickettsia prowaz...
Q8TU79    177 vDPFAVTYKEEPWAGGGna--gPCVEVIVHg-----------------------LELATLVFMDLktdkkgdil-----i 226  Methanosarcina ac...
Q8TWY1    182 iPEEKIAFKESWWEGGGna--gPCFEVVVDg-----------------------LELATLVFMQYeqvgg---------- 226  Methanopyrus kand...
O58035    180 mKPEDITFKENPWAGGGna--gPAFEVLYRg-----------------------LEVATLVFMQYkkapenapqdqvvvi 234  Pyrococcus horiko...
P96041    181 iPEEELNFKESWWEGGGna--gPCLEVTVGg-----------------------LELATLVFMQYkitdn---------- 225  Sulfolobus solfat...
Q9Y9X3    165 iPPELIVFKESWWEGGGna--gPSFEVAVGg-----------------------LELATLVFMKYrvvdg---------- 209  Aeropyrum pernix
O28029    179 vKKEDIVYKEEPWAGGGna--gPCLEAIVGg-----------------------LEVATLVFMNLeehpegdie-----i 228  Archaeoglobus ful...
Q9HJW4    180 iDGKLISFKEKPWSGGGna--gNALEVFVRg-----------------------LEVATLVFMDMkedpngpye-----i 229  Thermoplasma acid...
Q57984    177 iDEKSITFIESWWEGGGna--gPCYEVITHg-----------------------VELATLVFMQYekvgd---------- 221  Methanocaldococcu...
P47534    145 nHIIKCDKSRNFWDLGLgp-cgPCTEIYYDrgekfdpkkigeklffediendryVEIWNIVFSQFnndgn---------- 213  Mycoplasma genita...

Feature 1                ##   ##  #        
Q9ZCA4    217 --etrieLPKKSIDTGMGLERMTAVLQHV 243  Rickettsia prowazekii
Q8TU79    227 kgetyskMDNYIVDTGYGLERFVWASKGS 255  Methanosarcina acetivorans
Q8TWY1    227 ---eyreLPQKIVDTGYGIERYAWITTGE 252  Methanopyrus kandleri
O58035    235 kgekyipMETKVVDTGYGLERLVWMSQGT 263  Pyrococcus horikoshii
P96041    226 --gdyipLKLKIVDTGYGVERIAWVTQKT 252  Sulfolobus solfataricus
Q9Y9X3    210 ---ryeeIPLKIVDTGYGVERLAWFTQKT 235  Aeropyrum pernix
O28029    229 kgaryrkMDNYIVDTGYGLERFVWASKGT 257  Archaeoglobus fulgidus
Q9HJW4    230 dgiryskMDMRIVDTGYGLERLTWLSQGT 258  Thermoplasma acidophilum
Q57984    222 ---nykeIPLKIVDTGYGIERFVWASTGE 247  Methanocaldococcus jannaschii
P47534    214 --gnyteLAQKNIDTGAGIERLVSVLQNS 240  Mycoplasma genitalium

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