1LKO,1JI4,2GYQ,2IB0,3EE4,1MTY,1KGN,2OC5,1OQ9,2ITB,2OH3,2CLB,1JKV,1BCF,2QQY,1VLG,1MTY


Conserved Protein Domain Family
Ferritin_like

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cd00657: Ferritin_like 
Click on image for an interactive view with Cn3D
Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).
Statistics
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PSSM-Id: 153097
View PSSM: cd00657
Aligned: 132 rows
Threshold Bit Score: 35.5497
Threshold Setting Gi: 113982
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dinuclear metal
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:dinuclear metal binding motif [ion binding site]
Evidence:
  • Comment:Most diiron-carboxylate proteins have duplicate glutamate and histidine (ExxH) ligands and two additional glutamate ligands within a four-helix bundle.
  • Comment:L chains of vertebrate ferritins and beta-subunits of aromatic and alkene monooxygenase hydroxylases lack diiron ligands.
  • Citation:PMID 8749363

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                                #  #                                  
1LKO_A        11 KNILTAFAGESQARNRYNYFGGqakkdgfvqISDIFAETADQEREHAKRLFKfleggdleiva----afpagiiadthAN 86  Desulfovibrio v...
ZP_04385187   12 SALLTAIESENAAIFAYGVVAAfsn----paRVNEVATHTAAHRARRDALVAlstdagvtpptaaaayeipfpvtdavTA 87  Rhodococcus ery...
ZP_04026644    6 EAVVAALHAEYAAIYLYGVVDAyas----ptRRADIAKFAAEHRAQRDALQTalgaagvpvpvaaaayappepvtdpvSA 81  Tsukamurella pa...
ZP_04608086   12 EALAGALAAEYAAVFAYGVIGVrla----daARTAARRAETAHRSRRDALVLqlseagsavpadkagytlpfpvtdaaTA 87  Micromonospora ...
YP_003118417   2 SALQTALGNEHAAVYGYGVLAVhlv----gaQQNAARNAYDTHRARRDILIGlieaqgdkpvaaapayaipfpvnsaaDA 77  Catenulispora a...
NP_823732     22 RALQAALGAEHAAVYGYGVVGGkig----qaRRADARAAYDAHRARRDELARsvrdlggtpqaaaagyalpfavpdatAA 97  Streptomyces av...
ZP_03866113    9 EALQAAIAGEHAALYGVGVAGGkls----gaRFRAATTLYEQHRKRRDLLADllvqsgqtpaaaepaydlpqvvtdpaTA 84  Kribbella flavi...
YP_924384      5 DALQIALAAEHAAVYVYGALGGrtsrsatpeLFASVVRAYDAHRARRDRLTAtildegaepvaae-payelprldtpaQV 83  Nocardioides sp...
ZP_03891111   14 AALNEVVAAEHAAVWGYGAVGAalp----gdARGPAAAAEVAHRDARDRLVAllesrgadpapreagytlpfpvlsevDA 89  Geodermatophilu...
YP_288834     18 AALRDALLAEHAAVYGYSFAAAhtd----adLRSLCLSHLEKHRAWRDTLHSalvardavppgge-dayqlpehtgpeEL 92  Thermobifida fu...
Feature 1               #                                 #  #        
1LKO_A        87 LIAsAAGEHHEYtEMYPsfariareegyeeiarvFAsIAVAEEFHEKRFLDFA 139 Desulfovibrio vulgaris
ZP_04385187   88 AQLaAQIESDTA-VTYRafveqvd---tdqlrtfGIdGLTDAAIRGAGWRSAL 136 Rhodococcus erythropolis SK121
ZP_04026644   82 AKVaAAIEDDSA-AAYRgvlsrgd---sdglrhlGVtGLSAAAVRGARWRVAL 130 Tsukamurella paurometabola DSM 20162
ZP_04608086   88 LRLaVEVEERTA-AFWRvalphtt----gadrdrALaALTDCAVRATRWRRTA 135 Micromonospora sp. ATCC 39149
YP_003118417  78 LRLaAQLEERLG-ASYAdvvqsss----gdtrrtGLeWLTDAAVRAVRWRGTS 125 Catenulispora acidiphila DSM 44928
NP_823732     98 VRLaAELEERVA-GVYSdlvragt----garrrsAAeALREAAVRAVRWSGES 145 Streptomyces avermitilis MA-4680
ZP_03866113   85 VALvLGIERRLG-AVYAdlveaae---qdgprtfAVqALIATAREQLAWGGRP 133 Kribbella flavida DSM 17836
YP_924384     84 DRAaLAVERACA-ATYAylvehtv----geqrrsAVgALNEAAVRELVFRGTP 131 Nocardioides sp. JS614
ZP_03891111   90 ATLaVALEEGVS-AAWVrvldqaa---epavrelAVgELGAAEVRAVGWRAAA 138 Geodermatophilus obscurus DSM 43160
YP_288834     93 RSFaAGLEETTA-QAYLelaavpd----aglrdlAGrALGEATLRMLALGGQL 140 Thermobifida fusca YX

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