1EYV,1EY1


Conserved Protein Domain Family
Terminator_NusB
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cd00619: Terminator_NusB 
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Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus factors (NusA, NusE/S10 and NusG) forms the core complex with the boxA element of the nut site of the rRNA operons. These interactions help RNA polymerase to counteract polarity during transcription of rRNA operons and allow stable antitermination. The transcription antitermination system can be appropriated by some bacteriophages such as lambda, which use the system to switch between the lysogenic and lytic modes of phage propagation.
Links
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Statistics
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PSSM-Id: 238342
Aligned: 16 rows
Threshold Bit Score: 127.01
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative RNA
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:NusB binds the dodecameric boxA RNA motif
  • Structure:1EYV; Mycobacterium NusB with bound phosphate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #   #                                                                           
1EYV_B     10 RHQARKRAVALLFEAEVR-----------GISAAEVVDTRAAlaeakpdiarlhPYTAAVARGVSEHAAHIDDLITAHLR 78  Mycobacterium tube...
2982469   140 KTETKEEEDELVRHDEKE-----------SKIEAEVLSAPPKlvys----klvlRFAKKLLAAVVDKWDSHVVIIEKISP 204 thale cress
6225786    28 KSIARIAAVQALYQNILQnnydmydimqnILACYHSNNSIDLpknfk--islsiSHFKMLVKSVFENINKLDEIIDNHLT 105 Rickettsia prowazekii
7387971     4 MHEVRVLAFQKIYSIDINqs--------aMDDIFDIFNIEDKdldie--nesikSFYSSLVIGTFDNLEHIDSLIRDISL 73  Lyme disease spiro...
7387972     4 RKGARDTAFLVLYRWDLRg----------ENPGELFKEVVEEknikn---kdayEYAKKLVDTAVRHIEEIDSIIEKHLK 70  Aquifex aeolicus
7387973    10 RRRARILAFQALFAWDAAgi--------tPETLTQFTWLRRNppps----tqdlGFSRLLFLGTLEHLREIDGCVSSRLE 77  Treponema pallidum
7387974    21 KQKLRELVLQALYALEID-----------PEGEDSLVSLLMTeasvs---kknaAYALMFCRAIRANQPDLDALLDATIR 86  Chlamydia trachomatis
7387977     5 RRRMRLAVFKALFQHEFRr----------DEDLEQILEEILDetyd----kkakEDARRYIRGIKENLSMIDDLISRYLE 70  Thermotoga maritima
7387979    22 QQKMREIILQMLYALDMA-----------PSAEDSLVPLLMSqtavs---qkhvLVALNQTKSILEKSQELDLIIGNALK 87  Chlamydophila pneu...
7387981     4 RTQARGAVVELLYAFESGn----------EEIKKIASSMLEEkkik----nnqlAFALSLFNGVLEKINEIDALIEPHLK 69  Helicobacter pylor...

Feature 1                                                                          
1EYV_B     79 GWt--lDRLPAVDRAILRVSVWELLHAa---dVPEPVVVDEAVQLAKELStdDSPGFVNGVLGQVMLVT 142 Mycobacterium tuberculosis
2982469   205 PDwksaPAGRILEFSILHLAMSEVAVLe----TRHPIVINEAVDLAKRFCdgSAPRIINGCLRTFVKDR 269 thale cress
6225786   106 NAkd-sVHMPILLRALLRVSICELLFCs---tTPAKVVINEYTDIANDLLneHEIGFVNSILDKIAQEN 170 Rickettsia prowazekii
7387971    74 NWs--lERMDKVDLAILRMGVYSLKFQnf--eNSKRAIIDEAILIAKKYGskNSYKFINGILDALLKNM 138 Lyme disease spirochete
7387972    71 GWs--iDRLGYVERNALRLGVAELIFLks--kEPGRVFIDIVDLVKKYADe-KAGKFVNGVLSAIYKAY 134 Aquifex aeolicus
7387973    78 HWd--fVRLNKVDKAILRLSAYSLLFQk---dIPPVVVIHEAVSIARDFGtdDSFRFVNGVLDNIAKSA 141 Treponema pallidum
7387974    87 TTt--lARLTIIERNILRMMLFEHQQNqdccpVPVAVLIAETTRLIKKFSysEGSSLILAVLGSIFDHP 153 Chlamydia trachomatis
7387977    71 KWs--lNRLSVVDRNVLRLATYELLFEk---dIPIEVTIDEAIEIAKRYGteNSGKFVNGILDRIAKEH 134 Thermotoga maritima
7387979    88 NKs--fDSLDLVEKNVLRLTLFEHFYSp---pINKAILIAEAIRLVKKFSysEACPFIQAILNDIFTDS 151 Chlamydophila pneumoniae
7387981    70 DWd--fKRLGSMEKAILRLGAYEIGFTp----TQNPIIINECIELGKLYAepNTPKFLNAILDSLSKKL 132 Helicobacter pylori J99

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