1ORD,1C4K


Conserved Protein Domain Family
Orn_deC_like

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cd00615: Orn_deC_like 
Click on image for an interactive view with Cn3D
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Statistics
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PSSM-Id: 99739
View PSSM: cd00615
Aligned: 21 rows
Threshold Bit Score: 342.691
Threshold Setting Gi: 27469220
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1ORD; catalytic residue and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1ORD_A    109 PFFKSLKEYVSrgliqFDCPGHQGGQyyrkhpagrefydfFGETVFRADLCnaDVALGDLLIHEGPAVAAEKHAARvynA 188 Lactobacillus sp.
NP_561465  10 PIYEALKWYKNqrivpFDVPGHKQGRgnte------lrefLGEDCVSVDVNs-MKPLDNLCHPTSVIKDAEELAAEa-fG 81  Clostridium perfri...
P21885      7 PLYTGLKKHASrqpvqFHIPGHKKGAgmdpe-----frqfIGENALSIDLIn-IEPLDDLHAPKGIIKQAQDLAAEa-fG 79  Bacillus subtilis
P37536      4 PLYKALIQHARrnshsFHVPGHHNGDvffd------daksIFDPLLTIDVTe-LAGLDDLHHPSGVIKEAQELASQl-yG 75  Bacillus subtilis
NP_240907   8 PLFERLVQHDRggpisCHVPGHKQGAlfhk------dacsYFQSILSLDVTe-LTGLDDLHDPRGVIAEAQALTARy-vG 79  Bacillus halodurans
NP_348954  10 PLFNALMEYVNrdtipFHVPGHKKGNgidke-----fknfIGENPFKIDVTv-FKLVDSLHHPTGPIKKAQELAADa-yG 82  Clostridium acetob...
NP_345400  10 PIYEALVKLRKkrivpFDVPGHKRGRgnpe------lvelLGEKCVGIDVNs-MKPLDNLGHPISIIRDAEELAADa-fG 81  Streptococcus pneu...
NP_765857   4 PIIQKLNHLIEkkaisMHVPGHKNMTig-----------yLNRLDLAMDMTe-ITGLDDMHYPEGIILESMENFRKh--K 69  Staphylococcus epi...
NP_780930   5 PLVEGVLNYIKkkniyFSMPGHKQGEgflst----digkeIKEQILKLDITe-VNGVDNLHNPTGIIKESQIKLSEl-yG 78  Clostridium tetani...
AAO73275   37 PLIQALKSTANqdvscFHFPGHNRGKaspps-----lselIGSRTFLHDLPe-LPELDDLFSPKGVILDAQKRAAEl-fG 109 Japanese rice
Feature 1                                                                                     
1ORD_A    189 DKTYFV-LGGSSNANNTVTSALvSNGDLVLFDRNNHKSVYNSALAMaggRPVYLQTNRNPy-GFIGGIYDSDFDEkkire 266 Lactobacillus sp.
NP_561465  82 ADKAFFmVNGTTSAVQAMIMSVcKDGDKIIMPRNVHRSAINSLIITg-vTPVYINPGIHGrlGISLGMAMEDIKKaike- 159 Clostridium perfri...
P21885     80 ADHTFFsVQGTSGAIMTMVMAVcGPGDKIIIPRNVHKSIMTAIVFSg-aVPIFIHPEIDNelGISHGITLESAKRalte- 157 Bacillus subtilis
P37536     76 SAESFFlVNGTTVGNLAMILSVcEPGDTILVQRNCHKSVFHAVDLSg-aEPVYLAPDVDSamHVPTHVPLGTIKEalea- 153 Bacillus subtilis
NP_240907  80 AEATCFlVNGSTVGNLAMILGTlEPGDTVFVQRDSHKSVMNGLAMAr-vHPIFLSPSYDErtQLPTGITEQTLKQalie- 157 Bacillus halodurans
NP_348954  83 SKAAFYsVNGTSGAIQGMILSVvGDGDKIIVPRNVHKSVTAGIILSg-aVPVYMHPEVDRrvGIAHGVSPETVGEtlkn- 160 Clostridium acetob...
NP_345400  82 ASHAFLmIGGTTSSVQTMILATcKAGDKIILPRNVHKSAINALVLCg-aIPIYIEMSVDPkiGIALGLENDRVAQaikd- 159 Streptococcus pneu...
NP_765857  70 NYDAFLlVNGTTSGILSVIQAFsTRKGKYLISRNVHKSVFHGLDITq-qQATITKTDVSK--KTNQYVNPKINQDkn--- 143 Staphylococcus epi...
NP_780930  79 SKKSYFlVNGSSSGNMIMIFSSfEEGDKIIIDRNCHKSIFNTIIIRk-lKAIYVKNKIHKgfNLPLSVDSSHIIKtike- 156 Clostridium tetani...
AAO73275  110 SFKTWFlVNGSTCGIQASVMATcSPGDYLIIPRNCHISVISALVLSg-aVPKYIVPEYNSgwDIAGGITPSQVDKvvkel 188 Japanese rice
Feature 1                                                                                     
1ORD_A    267 laakvdperakwkrpFRLAVIQLGTYDGTIYNAHEVVKRIghlcDYIEFDSAWVGYEqFIPMMRNSSplliddlgpedpg 346 Lactobacillus sp.
NP_561465 160 ------------npdAKAIFVNNPTYYGICSNLREIVKLAhennMYVLVDEAHGTHFyFDKRLPVSAmea--------ga 219 Clostridium perfri...
P21885    158 ------------hpdAKGLLVINPTYFGVAADLKSIVELAhsfdVPVLVDEAHGVHIhFHDELPLSAmqa--------ga 217 Bacillus subtilis
P37536    154 ------------ypdAKGLVLTNPTYYGHSADLTEIITEAhhygIPVLVDEAHGAHFiLGEPFPVSAlkm--------ga 213 Bacillus subtilis
NP_240907 158 ------------hpnGKALILTYPSYYGVARSIRPLVQMAkeagLYVLVDEAHGAHFpVGDPFPKQAleq--------ga 217 Bacillus halodurans
NP_348954 161 ------------npdAKAVLLINPTYYGVSTDIKKIADIVhsydIPLIVDEAHGPHLsFNDRLPVSAlka--------ga 220 Clostridium acetob...
NP_345400 160 ------------hpdAKAILINNPTYYGICSDLKGLTEMAheagMMVLVDEAHGAHLhFTDKLPISAmda--------ga 219 Streptococcus pneu...
NP_765857 144 -------------qyYKLAICTYPNYYGETFDISQYIKQLhhrgIPILVDEAHGAHFgLDGFPESSMnf---------na 201 Staphylococcus epi...
NP_780930 157 ------------nkdAKGIIITYPNYYGICCDLEKIIIEAkkhnMKVLIDCAHGAHFvANEKLPKNPvkl--------ga 216 Clostridium tetani...
AAO73275  189 e---------edrkkVGAVLVTSPTYHGICSNIQGIVNVChlqgIPVIVDEAHGAHFrFHRNFPSSAteq--------ga 251 Japanese rice
Feature 1             #                                                                       
1ORD_A    347 IIVVQSVHKQQAGFSQTSQIHKKdshikgqlrycDHKHFNNSFNLFMSTSPFYPMYAALDVNAamqe---geaGRKLWHD 423 Lactobacillus sp.
NP_561465 220 DMAAVSIHKTGGSLTQSSMLLMKcn-------riKPDYVRTIINLTQTTSGSYLLLSSLDIARrnl----alnGEKIFEE 288 Clostridium perfri...
P21885    218 DIAATSVHKLGGSLTQSSILNMReg-------lvSKDRVQSILSMLTTTSTSYLLLASLDVARkrl----ateGRQLAEE 286 Bacillus subtilis
P37536    214 DIVVQSAHKTLPAMTMGSYLHLNssc------riNRDRVAEYLNRLQSSSPSYPIMASLDIARayvq---hiiEEQKLSD 284 Bacillus subtilis
NP_240907 218 DVVVQSAHKTLPALTMGSYLHFAhgl-----hskIKDSIREQLQILQSSSPSYPILASLDAARgf------leDLTNVKD 286 Bacillus halodurans
NP_348954 221 DMCAQSTHKIIGALTQMSLLHVNsd-------riDMNRVQQIMNLLQTTSPSYILMASMDCARrqi----alhGKELLDG 289 Clostridium acetob...
NP_345400 220 DMAAVSMHKSGGSLTQSSILLIGeq--------mNSEYVRQIINLTQSTSASYLLMASLDISRrnl----alrGKESFEK 287 Streptococcus pneu...
NP_765857 202 DYVVQSYHKTLPALTMGSVIYIHkd-------apLRQQVIDYLTYFQTSSPSYLIMSSLELANkfykeydstlFDQRRKM 274 Staphylococcus epi...
NP_780930 217 DMVVMSSHKTLPSLTQTAFLHVNne--------eLIDKVDFYFDTFISTSPSYLFLVSMDYSRyyl----eeyGEETYEK 284 Clostridium tetani...
AAO73275  252 DLVVQSTHKVLCSLTQSSMLHMAgd-------lvDADKVSQCLQLLQSSSPSYLLLSSLDAARaqlse-naesFDEPVSM 323 Japanese rice
Feature 1                   
1ORD_A    424 LLITTIEARKKLIK 437 Lactobacillus sp.
NP_561465 289 VVGIAEYAREEINK 302 Clostridium perfringens str. 13
P21885    287 TLKLANQTRDRLNQ 300 Bacillus subtilis
P37536    285 ILQRIETLKQTFDS 298 Bacillus subtilis
NP_240907 287 TLDSIAEMNRRIEQ 300 Bacillus halodurans
NP_348954 290 TIDLCNYARREINK 303 Clostridium acetobutylicum
NP_345400 288 VIELSEYARREINA 301 Streptococcus pneumoniae TIGR4
NP_765857 275 LIDLLVNMGFTVIE 288 Staphylococcus epidermidis ATCC 12228
NP_780930 285 LIKLLKIYKQKINS 298 Clostridium tetani E88
AAO73275  324 ALETKHQLRIIPGI 337 Japanese rice

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