1BJO,1BT4


Conserved Protein Domain Family
PSAT_like

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cd00611: PSAT_like 
Click on image for an interactive view with Cn3D
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.
Statistics
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PSSM-Id: 99736
View PSSM: cd00611
Aligned: 15 rows
Threshold Bit Score: 549.974
Threshold Setting Gi: 1711380
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1BT4; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1BJO_A      3 FNFSSGPAMLPAEVLKQAQQELRDWnglgtSVMEVSHRGKEFIQVAEEAEKDFRDLLnvpsnYKVLFCHGGGRGQFAAVP 82  Escherichia coli
1BT4_A      6 YNFNAGPAALPLEVLERAQAEFVDYqhtgmSIMEMSHRGAVYEAVHNEAQARLLALLgnptgYKVLFIQGGASTQFAMIP 85  Bacillus circulans
Q10349      8 VNFAAGPAAMITSVVEEFGKDFVNFqglgmGVAEISHRSKQGSGIVTSAESNFRKLYnipenFHILFMQGGGTEQFAACL 87  fission yeast
NP_388883   5 TNFNAGPAALPLEVLQKAQKEFIDFnesgmSVMELSHRSKEYEAVHQKAKSLLIELMgipedYDILFLQGGASLQFSMLP 84  Bacillus subtilis ...
NP_281517   4 INFSAGPSTLPLEILEQAQKELCDYqgrgySIMEISHRTKVFEEVHFGAQEKAKKLYelnddYEVLFLQGGASLQFAMIP 83  Campylobacter jeju...
NP_810066   4 HNFNAGPSILPREVIEDTAKAILDFngsglSLMEISHRAKDFQPVVDEAEALFKELLnipegYSVLFLGGGASMEFCMVP 83  Bacteroides thetai...
P10658      8 VNFGPGPAKLPHSVLLEIQKELLDYkglgiSVLEMSHRSSDFAKIVNNTENLVRELLavpdnYKVIFLQGGGCGQFSAVP 87  rabbit
P33330      9 QHFGAGPAQMPTPVLQQAAKDLINFndiglGIGEISHRSKDATKVIEDSKKHLIELLnipdtHEVFYLQGGGTTGFSSVA 88  baker's yeast
AAH44467    7 VNFGAGPAKLPQSVLLQAQKELLDYsgtgiSILEMSHRSSDFTKIINTTENLIRELLnvpenYKILFLQGGGSGQFSAVP 86  zebrafish
Q9VAN0      3 INFAAGPAKLPEEVLKEVQENLVNCngsgiSVMEMSHRSSNYAKIHDATISDLRELLnvpsnYKILLMQGGGTGQFAAVA 82  fruit fly
Feature 1                                                                                     
1BJO_A     83 LNIlgd---------ktTADYVDAGYWAASAIKEAKKY---CTPNVFdakvtv-dglraVKPMREWqls---dnAAYMHY 146 Escherichia coli
1BT4_A     86 MNFlke---------gqTANYVMTGSWASKALKEAKLI---GDTHVAassea--snymtLPKLQEIqlq---dnAAYLHL 148 Bacillus circulans
Q10349     88 YNVyahhalkngnakslVANYIITGAWSKKAYAEAERLg-fPCHVAVdmkela-gkygsLPEDKDLkftp-dgeTSLVYY 164 fission yeast
NP_388883  85 MNFltp---------ekTAHFVMTGAWSEKALAETKLF---GNTSITatset--dnysyIPEVDLTdv----kdGAYLHI 146 Bacillus subtilis ...
NP_281517  84 MNLal----------ngVCEYANTGVWTKKAIKEAQILg--VNVKTVassee--snfdhIPRVEFSd------nADYAYI 143 Campylobacter jeju...
NP_810066  84 FNFle-----------kKAAYLNTGVWAKKAMKEAKGFg--EVVEVAssaea---tytyIPKDYTIpa-----dADYFHI 142 Bacteroides thetai...
P10658     88 LNLiglk-------pgrCADYVVTGAWSAKAAEEAKKF---GTVNIVhpklg---sytkIPDPSTWnln---pdASYVYY 151 rabbit
P33330     89 TNLaaayvg--khgkiaPAGYLVTGSWSQKSFEEAKRLh-vPAEVIFnakdynngkfgkIPDESLWedkikgkaFSYVYL 165 baker's yeast
AAH44467   87 LNLiglk-------eerCADYLVTGTWSARAAKEAEKY---GKVNVIhpkld---sytkIPDSSTWsln---psASYVYY 150 zebrafish
Q9VAN0     83 LNLigk---------tgTADYVITGSWSAKAAKEAAQYgtvNAVLPKlak------yttVPRQETWkld---pnASYVYY 144 fruit fly
Feature 1                                                         #                           
1BJO_A    147 CPNETIDGIAIDETPdfg---adVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIgpAGLTIVIVREDllgkan------ 217 Escherichia coli
1BT4_A    149 TSNETIEGAQFKAFPdt----gsVPLIGDMSSDILSRPFDLNQFGLVYAGAQKNLgpSGVTVVIVREDlvaesp------ 218 Bacillus circulans
Q10349    165 CDNETVHGVEFNEPPtni--pkgAIRVCDVSSNFISRKIDFTKHDIIFAGAQKNAgpAGITVVFVRDSvlarptpael-- 240 fission yeast
NP_388883 147 TSNNTIFGTQWQEFPns-----pIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLgpSGVTVVIMKKSwlqnen------ 215 Bacillus subtilis ...
NP_281517 144 CSNNTIYGTQYQNYPkt-----kTPLIVDASSDFFSRKVDFSNIALFYGGVQKNAgiSGLSCIFIRKDmlersk------ 212 Campylobacter jeju...
NP_810066 143 TTNNTIYGTELKEDLns-----pVPMVADMSSDIFSRPIDVSKYICIYGGAQKNLapAGVTFVIVKNDavgkvs------ 211 Bacteroides thetai...
P10658    152 CANETVHGVEFDFVPdv----kgAILVCDMSSNFLSRPVDVSKFGVIFAGAQKNVgaAGVTVVIVRDDllgfal------ 221 rabbit
P33330    166 CENETVHGVEWPELPkclvndpnIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIglAGLTLYIIKKSilknisgasdet 245 baker's yeast
AAH44467  151 CCNETVHGVEFNFIPdt----kgVILVSDMSSNFLSRPVDVSKFGLIFAGAQKNVgcAGVTVVIVREDligkal------ 220 zebrafish
Q9VAN0    145 CDNETVEGVEFDFVPevp---agVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIgpAGTTVIIVRDDligkhl------ 215 fruit fly
Feature 1                                                                                     
1BJO_A    218 ------iacpsILDYSILNDNGsmfNTPPTFAWYLSGLVFKWLKAnGGVAEMDKINQQKAELLYGVIDNs-dFYRNdvak 290 Escherichia coli
1BT4_A    219 ------khlptMLRYDTYVKNNslyNTPPSFGIYMVNEVLKWIEErGGLEGVQQANRKKASLIYDAIDQsggFYRGcvdv 292 Bacillus circulans
Q10349    241 -hklnipvsptVSDYKIMADNHslyNTLPVATLHAINLGLEYMLEhGGLVALEASSIEKSKLLYDTLDKh-dLYISvvep 318 fission yeast
NP_388883 216 ------anvpkILKYSTHVKADslyNTPPTFAIYMLSLVLEWLKEnGGVEAVEQRNEQKAQVLYSCIDEsngFYKGhark 289 Bacillus subtilis ...
NP_281517 213 -----nkqipsMLNYLTHAENQslfNTPPTFAIYMFNLEMDWLLNqGGLDKVHEKNSQKATMLYECIDLsngFYKGhadk 287 Campylobacter jeju...
NP_810066 212 ------ryipsMLNYQTHIDNGsmfNTPPVVPIYAALLNLRWIKAqGGVKEMERRAIEKADMLYAEIDRn-kLFVGtaak 284 Bacteroides thetai...
P10658    222 ------recpsVLEYKVQATSSslyNTPPCFSIYVMGLVLEWIKNnGGAAAMKKLSTIKSQMIYEIIDNsqgFYVCpvep 295 rabbit
P33330    246 lhelgvpitpiAFDYPTVVKNNsayNTIPIFTLHVMDLVFQHILKkGGVEAQQAENEEKAKILYEALDAnsdFYNVpvdp 325 baker's yeast
AAH44467  221 ------kecpiILDYQVQAGNNslyNTPPCFSIYIMGLVLEWIRNnGGADAMERLNKQKSALVYDIINRsngFYSCpvda 294 zebrafish
Q9VAN0    216 ------kitpsILNFEQMDKNNsllNTPPTFGIYVMGLVFKWIKRnGGVAGMAKLAAAKSKLIYDTINQsngFYYCpvdv 289 fruit fly
Feature 1                                                                            
1BJO_A    291 rnRSRMNVPFQlads----aldKLFLEESFaaglhALKGHrvvgGMRASIYNamPLEGVKALTDFMVEFER 357 Escherichia coli
1BT4_A    293 dsRSDMNITFRlase----eleKEFVKASEqegfvGLKGHrsvgGLRASIYNavPYESCEALVQFMEHFKR 359 Bacillus circulans
Q10349    319 aaRSRMNVTFRiepq----eleSEFLAEAEkhhlvQLKGYrsvgGIRASLYNaiSVEQTRRLIDLLESFAK 385 fission yeast
NP_388883 290 dsRSRMNVTFTlrdd----eltKTFVQKAKdakmiGLGGHrsvgGCRASIYNavSLEDCEKLAAFMKKFQQ 356 Bacillus subtilis subsp. su...
NP_281517 288 kdRSLMNVSFNiakn---kdlePLFVKEAEeagmiGLKGHrilgGIRASIYNalNLDQVKTLCEFMKEFQG 355 Campylobacter jejuni subsp....
NP_810066 285 edRSRMNICFVmapey--kdleADFMKFATekgmvGIKGHrsvgGFRASCYNalPKESVQALIDCMQEFEK 353 Bacteroides thetaiotaomicro...
P10658    296 rnRSMMNIPFRignakgdealeKRFLDKALelhmiSLKGHrsvgGVRVSLYNavTIEDVQKLASFMKNFLE 366 rabbit
P33330    326 kcRSKMNVVFTlkkd----gldDQFLKEAAarhltGLKGHrsvgGFRASIYNalSVKAVQNLVDFIKEFAE 392 baker's yeast
AAH44467  295 acRSRMNIPFRigkkegdesleKSFLDGASklgmiSLKGHrsvgGIRASLYNavTVEDVKILAAYMEDFLR 365 zebrafish
Q9VAN0    290 nvRSRMNVPFRigsasgddaleKEFLSKAEaegmiQLKGHrsvgGIRASLYNavTLAETQQLANLMLAFYK 360 fruit fly

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