2EO5,1OHV,1GBN,1Z7D,1VEF,2PB0,2ORD,2CJD,1SZU,1D7U,2CY8,2GSA,2E7U,2EPJ,3BV0,1QJ3


Conserved Protein Domain Family
OAT_like

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cd00610: OAT_like 
Click on image for an interactive view with Cn3D
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.
Statistics
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PSSM-Id: 99735
View PSSM: cd00610
Aligned: 161 rows
Threshold Bit Score: 268.668
Threshold Setting Gi: 15891268
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:2EO5_A; 4-Aminobutyrate-Aminotransferase catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2EO5_A      6 IIEESDIYlatstr-------dpelfpLVIDhGEGVWIYDvdgNKYLDftsgigVNNLGWpSHPEVIKIgieqmqklaHA 78  Sulfolobus tokodai...
NP_435764  21 LFDRAKGVftdgttra---sverdpfpIYAQrGEGAYLVDvdgNRLLDlnnnftTLIHGH-GFAHVSEAvvdllrlgtCF 96  Sinorhizobium meli...
NP_714557  23 LFERAKKVspggvhspvrsfrsvggtpVFFAsAKGATLTDisgKEYIDyclsfgPLILGH-RDPEVEEVvretteiawSF 101 Leptospira interro...
2EPJ_A     15 LFERTKELfpggvnspv--raavkpypFYVKrGEGAYLYTvdgARIVDlvlaygPLILGH-KHPRVLEAveealargwLY 91  Aeropyrum pernix
NP_341738  14 LWAQAKQLfaggvnspv--raavkpfpFYVErGKGAYIYTvdgKKFIDyvlgygPLILGH-SPESVKRRiveqlergwLF 90  Sulfolobus solfata...
Q8TYL6     13 LFKRAERVmpggvssp---vrrfdpypFYVErAEGSRLYTvdgHVLIDyclafgPLILGH-AHPEVVEAvvervregfHY 88  Methanopyrus kandleri
Q58020     11 LFEEAKKYlvggvnsp---vryfkpypFFVEkAKDCYLFDvdgNCYIDyclaygPMVLGH-ANDAVIKAvkeqlelgsAY 86  Methanocaldococcus...
NP_871076  10 LYVEAKKIipggvnsparsfyfvkeipVIAKrSKGPYIFDvdnNKYIDyicswgASILGH-NNYYITSKiieyskkglNF 88  Wigglesworthia glo...
Q9JRW9     12 TFEEACQVfpggvnspvracrsvgvtpPIVSsAQGDIFLDthgREFIDfcggwgALIHGH-SHPKIVKAiqktalkgtSY 90  Chlamydophila pneu...
NP_105861  40 KVGNGLPGffggvpmhw-mndwptpfpILVDsAKGAAITDidgNRLDDfclgdtGSMFGH-SPPPVARAirrqagrglTY 117 Mesorhizobium loti
Feature 1                                                                                     
2EO5_A     79 AandfynIPQLELAKKLVTyspgnfqkKVFFSNSGTEAIEASIKVVKNtg-rkYIIAFLGGFHGRTfgsisltaska--- 154 Sulfolobus tokodai...
NP_435764  97 Anp---tEHEIALAELLTArip--ameRVRFVNSGTEAVMFAIKAARAftarpAIARIEGAYHGAYdwaeagqgvspgkd 171 Sinorhizobium meli...
NP_714557 102 Gaa---ePYSLELAELISSrvp--waeKVRFVNSGTEAVMSALRVARAatgreKILKFDGCYHGHLdsllvkagsglage 176 Leptospira interro...
2EPJ_A     92 Gap---gEAEVLLAEKILGyvk--rggMIRFVNSGTEATMTAIRLARGytgrdLILKFDGCYHGSHdavlvaagsaaahy 166 Aeropyrum pernix
NP_341738  91 Gtp---sELEIELARKIRShip--saqKIRFVNSGTEATMAAIRLARGytkrsKILKFSGNYHGAHdyalveagsaatey 165 Sulfolobus solfata...
Q8TYL6     89 Gtp---tLPELKLAEKVVElvp--nveKVRLVNTGTEATMSAIRLARAytgreKIVKFEGCYHGAHdavlvragsgasel 163 Methanopyrus kandleri
Q58020     87 Gcp---tEKEIILAKEVVKrvp--caeMVRFVNSGTEATMSAIRLARGvtgrkKIIKFDGAYHGAHdyvlvksgsgalth 161 Methanocaldococcus...
NP_871076  89 Gll---tEIEIKIARLISKyip--sieMIRMVNSGTEATMSAIRLARSytkknKIIKFDGCYHGHAdfllansnldpydl 163 Wigglesworthia glo...
Q9JRW9     91 Glt---sEEEILFATMLLSslkl-kehKIRFVSSGTEATMTAVRLARGitnrsIIIKFIGGYHGHAdtllggistteeti 166 Chlamydophila pneu...
NP_105861 118 Mlp---sEDALAIGPLLQQrfg---lpFWQIATTATDANRFSLRVARAvtgreKILVFNGCYHGSVdetmvrliggkpvn 191 Mesorhizobium loti
Feature 1                                                                                     
2EO5_A    155 ----------vqrsivgpfmpGVIHVPYpnpyrnpwhingyenpselvnrvIEFIEDYIfvnlvppeeVAGIFFEpIQGe 224 Sulfolobus tokodai...
NP_435764 172 gwdpipiptptyrgtpssvadEVHLLRFn---------------------dVEGLERRLsaa---sdrIACVLIDpMPSr 227 Sinorhizobium meli...
NP_714557 177 -------sssdsagisatsiaNTLVLPLd---------------------dEASVERVFete---gknIAALIIEpLPAn 225 Leptospira interro...
2EPJ_A    167 -------gvptsagvpeavarLTLVTPYn---------------------dVEALERVFaey---gdrIAGVIVEpVIAn 215 Aeropyrum pernix
NP_341738 166 -------nvatsdgvpmeimkTVEICEFn---------------------dLDCVDKKLrn-----edIATVILEpVMGn 212 Sulfolobus solfata...
Q8TYL6    164 -------gapdspgipesvaeNTLVCPFn---------------------dVEAFVETVerf---deeIGAVIVEpVLGn 212 Methanopyrus kandleri
Q58020    162 -------ghpnspgipeettkNTILIPFn---------------------dEDAVKKAInen---kdeIACIIVEpIMGn 210 Methanocaldococcus...
NP_871076 164 f-----ssnpissgipknilkDTLICPYn---------------------dYESIEKIFdly---pnkIACIIVEpIAGn 214 Wigglesworthia glo...
Q9JRW9    167 -------dnltslihtpsphsLLISLPYn---------------------nSQILHHVMeal---gpqVAGIIFEpICAn 215 Chlamydophila pneu...
NP_105861 192 --------rpglagefrdltrTAKVIEFn---------------------dVAALEAALkd-----rdVACVIAEpVLTn 237 Mesorhizobium loti
Feature 1                                                             #                       
2EO5_A    225 ggYVIPpknFFAELQKLAKKYgILLVDDEVQMGlgRTGKLFAIEnfntvPDVITLAKALgggimpIGATIFRkdldf--- 301 Sulfolobus tokodai...
NP_435764 228 agLLHPeptFIEALSETAHKYgILIVADEVLNL--RQGYAGASPryglkPDLVTAGKIIggg-fpIGAIGGReevmrvfg 304 Sinorhizobium meli...
NP_714557 226 ygLLIQrkeFLLKIVETARKYgTLVVFDEVISGf-RVGFQGMSGllgiwPDLVTYGKIIggg-fpVGCYAGKkdlldlva 303 Leptospira interro...
2EPJ_A    216 agVIPPrreFLAALQRLSRESgALLILDEVVTGf-RLGLEGAQGyfnieGDIIVLGKIIggg-fpVGAVAGSrevmsllt 293 Aeropyrum pernix
NP_341738 213 agVILPekdFLFGLRELTKTYnSLLIFDEVITGf-RISIGGAQSyyqiyPDITTLGKIIggg-fpIGAVAGKaeiidnft 290 Sulfolobus solfata...
Q8TYL6    213 agCVPPdeeFLKVLREYCDGTeRLLIFDEVITGf-RLELGGAQEyygidADLVCLGKILggg-lpIGAFGGPeeymsrva 290 Methanopyrus kandleri
Q58020    211 vgCILPkegYLEFLREITEENdILLIFDEVITGf-RLAKGGAQEyfgvvPDIATLGKILggg-fpIGAIVGRrelmeqfs 288 Methanocaldococcus...
NP_871076 215 mgCVLPeknFLYKLRMLCNKFnSLLIMDEIITGf-RISLGGAQSyyniyPDITCLGKIIggg-lpIGAFGGKkrimnhvs 292 Wigglesworthia glo...
Q9JRW9    216 mgIVLPkaeFLDDIIELCKRFgSLSIMDEVVTGf-RVAFQGAKDifnlsPDITIYGKILggg-lpAAALVGHrsildhlm 293 Chlamydophila pneu...
NP_105861 238 scMVLAdpgFHDALRRLTRETgTLLLIDETHTI--STGPGGYTRkyglePDFFVLGKPIagg-vpASVWGMSdevasrya 314 Mesorhizobium loti
Feature 1                                                                                     
2EO5_A    302 --------kpgmhSNTFGGNALACAIGSKVIDIVk--dLLPHVNEIGKIFAEELQgl------adDVRGIGLAWGLEYne 365 Sulfolobus tokodai...
NP_435764 305 t---enarpllpqGGTFSANPVSMAAGLAAMEAMtp-dAFDRLEAMGERLRAGLRasias-rdarFSVTGAASLFRIHpk 379 Sinorhizobium meli...
NP_714557 304 ------psgpvyqAGTLSANPFGMRAGLATLKKVqrdsIYSVLDDRTKIFTDTMTkllnkksnqeWEAVIHSSLFWFRkk 377 Leptospira interro...
2EPJ_A    294 ------pqgkvfnAGTFNAHPITMAAGLATLKALeeepVYSVSREAAKALEEAASevldrtglpyTINRVESMMQLFIgv 367 Aeropyrum pernix
NP_341738 291 ------pagkvfnAGTFNANPISMIAGIATIEELekeyPYIIANQAAKTLVEELErllk---tkhTINHVGSMFQIFFgi 361 Sulfolobus solfata...
Q8TYL6    291 ------pegkvyqAGTFNGNPVSATAGLVTLEVLererPYDELSSKAERLASALEdgledrgiegVVNRVESMFQVYFgi 364 Methanopyrus kandleri
Q58020    289 ------plgaiyqAGTFNGNPISITAGIATLKQLdd-rFYKETARTAKILADTLReladkhnikaKVYNIASMFQIYFnd 361 Methanocaldococcus...
NP_871076 293 ------psgsvyqAGTFSGNPISMISGYACLKLLkspdLYNKLNKKTEYLVNELRssacdnkipvVINSLGSMFSIFFtn 366 Wigglesworthia glo...
Q9JRW9    294 ------pegtifqAGTMSGNFLAMATGHAAIQLCqsegFYDHLSQLEALFYSPIEeeirsqgfpvSLVHQGTMFSLFFte 367 Chlamydophila pneu...
NP_105861 315 dynrtkepgysgmGTTLSANPLQFAAMRATLEEVmtaeNYDRMDHLAERLDAGLTgvidryrlpwHVARVGARVEFICap 394 Mesorhizobium loti
Feature 1                                                                       
2EO5_A    366 k----------------kvrDRIIGESFKRGLLLlpagrsaIRVIPPLVIseEEAKQGLDILKKVI 415 Sulfolobus tokodaii str. 7
NP_435764 380 rvapleyrdahlsaeeawimRTMSRYFLEAGILLpy---gaAACLSTPMVh-SDIDRILSAFDEFL 441 Sinorhizobium meliloti
NP_714557 378 tqqpirrid-lipeghkesfAKVFHTFLKNGIYLaps--gyEVGFLSWAHddEIIAKTLEIADKAL 440 Leptospira interrogans serovar l...
2EPJ_A    368 eevsnaaq---arkadkkfyVKLHEEMLRRGVFIaps--nlEAVFTGLPHqgEALEIAVEGLRSSL 428 Aeropyrum pernix
NP_341738 362 devrnysd---akradkeyyIKFHERLLKEGVFIpps--qyETIFTSAAHkdDVIADTIDKLMKVI 422 Sulfolobus solfataricus
Q8TYL6    365 eevrdyad---vnsadhdafKRFHRELLEHGVWIaas--nyEAWFLSIAHteTDLERTEEAFEEAL 425 Methanopyrus kandleri
Q58020    362 kevvnyei---akqsdtekfMKYFWRLLEKGVFVpps--qfECCFTSIKHddEVVDKTIKAMEDVF 422 Methanocaldococcus jannaschii
NP_871076 367 ldkikcyk--dvsscnykkfILFFNEIKKLGILFsps--lfESNFITLMHkkKDLEKTIDSANKVF 428 Wigglesworthia glossinidia endos...
Q9JRW9    368 saptnfde---aknsdvekfQTFYSEVFDNGVYLsps--plEANFISSAHteENLTYAQNIIIDSL 428 Chlamydophila pneumoniae
NP_105861 395 gplrngae--aetahapeleAAIHVALVNRGVLIap---fhNMMLISPATsgAQVNRLIAAFGAVA 455 Mesorhizobium loti

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