1HXQ,1GUQ


Conserved Protein Domain Family
GalT
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cd00608: GalT 
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Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.
Links
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Statistics
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PSSM-Id: 238341
Aligned: 25 rows
Threshold Bit Score: 364.317
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1GUQ_A:structure of galactose-1-phosphate complexed with udp glucose
  • Citation:PMID 9063869
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1HXQ_B       11 HRRYNPLTGQWILVSPHRAKRPWQGaqetpakqvlpahdpdCFLCAGNvrv---------------tgDKNPDYtgtYVF 75  Escherichia coli
1GUQ_A       11 HRRYNPLTGQWILVSPHRAKRPWQGaqetpakqvlpahdpdCFLCAGNvrv---------------tgDKNPDYtgtYVF 75  Escherichia coli
NP_696382    75 QMRRDPLTGDWIPMATARMNRPITAgpga--------takgNPLAARKpgdpy-----------qdgeVPDTDYn-vVVF 134 Bifidobacterium ...
NP_854294    77 RLRFDRATGQWVIVAAQRQDRTYKPpa------------arCPLCPGPtgl--------------sseVPAPDYd-vVVF 129 Mycobacterium bo...
O33836        3 ELRYNPLTDEWVIVSAATQKRPVQPsk------------teCPICVGGl-------------------ELPEEYd-lVTF 50  Thermotoga maritima
ZP_00112508  41 HLRWHPLRGEWVAYASHRQGRTFMPpp------------eyNPLAPTTnpef-------------pteLPQGKYd-vAVF 94  Nostoc punctiforme
AAL63309      2 EIRKDPFTGEYILVSPHRLKRPWQPeg-------------aCPFCPGAp-------------------ETGRGWd-vLIL 48  Pyrobaculum aero...
ZP_00082305  21 ELRWDPLKQHWVIIATDRGRRPRDFlvepep-----temtsCPFCYGNedktpgev----yvvrpvggANATGWk-vRVI 90  Geobacter metall...
NP_228704     3 EFRKDPIIKRWVIIATERAKRPHDFartkve----evregfCPFDYGNehttppeif---afrpadtePNTPGWw-vRVV 74  Thermotoga maritima
NP_867382   105 RSRKDPISGSWTIFAPGRARRPDQFkshrpk----pdasmdCPFCHGNenltpasvwsaklsedeeavPQSSDWt-vRVV 179 Pirellula sp. 1

Feature 1        ##                                                                             
1HXQ_B       76 TNDFAALmsdtpdapes--------------hdplmrcqsaRGTSRVICFSPDHS-KTLPELSVAALTEIVKTWQEQTAE 140 Escherichia coli
1GUQ_A       76 TNDFAALmsdtpdapes--------------hdplmrcqsaRGTSRVICFSPDHS-KTLPELSVAALTEIVKTWQEQTAE 140 Escherichia coli
NP_696382   135 ENRFPSMvrvpgvsedvty----------vdgnplwekklaAGRCEVICFDPNED-GLPADLPVSRLRTVVEAWAFRTAE 203 Bifidobacterium ...
NP_854294   130 ENRFPSLagagiapigap-------------dgdgfvsapgHGRCEVICFSADHT-GSFAGLDPAHAGLVVHAWRHRTAE 195 Mycobacterium bo...
O33836       51 ENRYPSLkkdpppvnwk--------------ekgpfrkeesRGVCEVVVYTSDHN-TALPGMPLKQIEKLVEMWVDRTRD 115 Thermotoga maritima
ZP_00112508  95 DNRFPSMtptannppd-----------------tivetlpaNGACEVVVFTQDAR-ASLSSLELDHLDLLLEVWGDRTRE 156 Nostoc punctiforme
AAL63309     49 PNRYPVVtenppepta----------------edlyevipaRGSSLVVVETPQHDvDDLSDLPLGQIKKILTAVAEAQRK 112 Pyrobaculum aero...
ZP_00082305  91 PNRFPVLriegelnsra---------------ygiydvmngIGAHEIIIETPDHN-RGLAELSPAEITEVLKAYRARFLD 154 Geobacter metall...
NP_228704    75 PNKFPAVdpnaplrkyg---------------rgmydaamgFGYHDVVVETPDHN-SHLAVMDYKNVEEVIWAYKIRYEQ 138 Thermotoga maritima
NP_867382   180 PNLFPAIkpesnaelkptaaddeaesrlspfaqslfveeiaSGGHEVIIEAARHT-RSLSELNLAEIALAFSAYAARMRH 258 Pirellula sp. 1

Feature 1                     #     # #      #                                                  
1HXQ_B      141 LG--KTYPWVQVFENKGAAMGCSNPHPHGQIWANSFLPNEAEREDRLQKEYfaeqkspmLVDYVQRELadgSRTVVETEH 218 Escherichia coli
1GUQ_A      141 LG--KTYPWVQVFENKGAAMGCSNPHPGGQIWANSFLPNEAEREDRLQKEYfaeqkspmLVDYVQRELadgSRTVVETEH 218 Escherichia coli
NP_696382   204 ISkmEGIEQIFPFENHGQEIGVSLAHPHGQVYCYPFIAPKMEKELQHTEAYhektggnlLKDIMNAELeagERIVMRNHS 283 Bifidobacterium ...
NP_854294   196 LTalPGVAQVFCFENRGEEIGVTLTHPHGQIYAYPYLTPRTAAMLRQARRHrkrhgdnlFASLLAREVadgSRIVVRGEL 275 Mycobacterium bo...
O33836      116 LSqhDFVKYIFIFENRGKEVGASLPHPHGQIYAFPFLPKRIEVKIGAMRKWyeekrkcpICEVLESEGe--ERKVYETEH 193 Thermotoga maritima
ZP_00112508 157 LGlnPQIQYVLPFENKGVEVGVTLHHPHGQIYAYPFIPPVPARMLSMQQEYyekhrrglLQDLIQKEIadnRRIIYQDEY 236 Nostoc punctiforme
AAL63309    113 AEkeGNAAYFLFFRNKGKEIGVSLTHPHSQIYILPVVPPRVRAELQASYEWyvk--hgsCLHCRIVEKe-eKRLVFQNRN 189 Pyrobaculum aero...
ZP_00082305 155 LRrdTRFRYMVLFKNHGRRAGATLSHSHSQLIAVPLIPPAAATELRVCREHyankerclFCDLLDFELqsgDRIVREFGN 234 Geobacter metall...
NP_228704   139 LMkdERIKYILIFKNHGRDAGASLSHPHSQIIALPIMPKRVQEELDGSKEYyeykercpFCDIIDEEKrerERIVEENDH 218 Thermotoga maritima
NP_867382   259 WRqqPGIQFISLFKNVGRDAGASLQHSHSQLIASNHLPHSVREVNKRMRSHfdrygrclQCDVLQAELerkERIVHQSDS 338 Pirellula sp. 1

Feature 1                                                                                       
1HXQ_B      219 WLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRsDLALALKKLTs--RYDNLFqc------sFPYSMGWHGAPfnge-- 288 Escherichia coli
1GUQ_A      219 WLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRsDLALALKKLTs--RYDNLFqc------sFPYSMGWHGAPfnge-- 288 Escherichia coli
NP_696382   284 WVAYVPAAARWPLEVHVAPVRDVLTLDQLNDEERwDLASMYSHLLk--RGNAFFdkgdgkgmdLPYIAAWHQAPihdk-- 359 Bifidobacterium ...
NP_854294   276 FTAFVPFAARWPVEVHIYPNRLVRNLTELNDGELdEFARIYLDVLq--RFDRMYss------pLPYMSALHQFSevq--- 344 Mycobacterium bo...
O33836      194 FLALVPFYARFPYEVHIYPKRHVSTLLEFSKEEKkEFAKVLKVVTa--KYDKLFdq------eFPYMMMFFQAPfnee-- 263 Thermotoga maritima
ZP_00112508 237 AIAFVPVCARYPYEVWIAPKEPVSTFMDLTPEQRwGLAKALKTVTl--KYDGLWnr------pFPYLMAWFQAPtdg--- 305 Nostoc punctiforme
AAL63309    190 WKAFVPFYAKWPHEVHIYPKRHRSLLTELTDEEVaDLAEALKITLcalKQVAGIp--------MPYIMVLHQAPlpr--- 258 Pyrobaculum aero...
ZP_00082305 235 YVIMTPYASCFPFELRLYPKRHSHDFALSTDGELaELAVALKDMLg--RLKSVLk-------dPPYNFILHTAPppqprl 305 Geobacter metall...
NP_228704   219 FIALEPFAARFPFETWILPKRHMNSFHLISEDEVgSLAKILKNVLy--RIYAALd-------nPPYNLLIHTAPtsl--- 286 Thermotoga maritima
NP_867382   339 LVAYCPHASRFPYLIRITSKMHVGCFEDLSVSMNeEVARLVLRSV---RWLEAIip------gVAYNMMLHTGPagdq-- 407 Pirellula sp. 1

Feature 1                                                                 
1HXQ_B      289 ------enqhWQLHAHFYPPLlrs-atvRKFMVGYemla-etqRDLTAEQAAERLRAV 338 Escherichia coli
1GUQ_A      289 ------enqhWQLHAHFYPPLlrs-atvRKFMVGYemla-etqRDLTAEQAAERLRAV 338 Escherichia coli
NP_696382   360 ------rrenYRLNLQFFSFRraa--nkIKYLAGSesgmaawiSDTTPELIAKRFHEL 409 Bifidobacterium longum NCC2705
NP_854294   345 --------rdGYFHVELMSIRrsa--tkLKYLAAAesamdafiADVIPESVAARLREL 392 Mycobacterium bovis subsp. bovis AF212...
O33836      264 -------dvsHFFHFHVEFNPpkrdrdkLKWMASVetgtwafiNPVVPEEAARQLRET 314 Thermotoga maritima
ZP_00112508 306 -------lahPEAHLHAEFFPpyrtserLKYLAGTelaagmfaNDALPEEKAKELQAV 356 Nostoc punctiforme
AAL63309    259 --------ptQYYHLHFEIYGmyrpdgkLKHAAGAelgaslftLDTTPEETAARIKAA 308 Pyrobaculum aerophilum str. IM2
ZP_00082305 306 gkpefwssieYDYHWHIELVPr------LTPIAGFewgtgfyiNPTSPEDAATFLRGA 357 Geobacter metallireducens
NP_228704   287 -------egkDYYHWHIEIFPrltkvagFEWGTGFy------iNTVPPEDAARYLREV 331 Thermotoga maritima
NP_867382   408 -------hdnETHHWSLELAPr------IGRLAGYelssggmiNTVYPEAAADEFRHQ 452 Pirellula sp. 1

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