Conserved Protein Domain Family
IPT_PCSR
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cd00603: IPT_PCSR 
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
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Statistics
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PSSM-Id: 238337
Aligned: 84 rows
Threshold Bit Score: 34.7378
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAB57274   842 PKILKLSPETGPrqgGTRLTITGENLGlrfedvrlGVRV-------GKV-LCSpvese---yisaeQIVCEIGDAssvra 910  human
JC5148     650 PIITSIRPSYGPragRTLLTIKGHYLDsgk---drKVYI-------GKE-MCNiksv------ssaAIVCLTPGQgttg- 711  African clawed frog
P16056     656 PVITSISPRYGPqagGTLLTLTGKYLNsgn---srHISI-------GGK-TCTlksv------sdsILECYTPAQttsd- 717  house mouse
T30809     660 PNITEIQPNYGPrigGTLITVTGSHLDsgk---trKVTL-------NEV-LCPikrvtq-pkgnvsSIICLSQHIsevr- 726  torafugu
CAA58863   657 PIITSISPTYGPksgGTLLTIAGKYLNsgk---srRIFV-------GEK-PCSlkst------sesSVECYTPAQripq- 718  chicken
NP_524616 1097 PRIMQIKPLRSFksgGRVLTVHGIYLNsiqk-pelEVFYdne--rvNKT-SCVvin--------snQMECPSPPVnykfe 1164 fruit fly
BAA31595  1129 PVITAISPRRSPvsgGRTITVAGERFHmvqn-vsmAVHHig----rEPT-LCKvln--------stLITCPSPGAlsna- 1193 human
P51805    1023 PTVTRLEPTWSIingSTAITVSGTHLLtvqe-prvRAKYrg----iETTnTCQvin--------dtAMLCKAPGIflgrp 1089 human
AAC18823   754 PHCSLIFPATTWisgGQNITMMGRNFDvid---nlIISHelkgninVSE-YCVa-----------tYCGFLAPSLkss-- 816  human
Q04912     875 PEEHAIKFEYIGl--GAVADCVGINVTvgg--escQHEFr-----gDMV-VCPlppslqlgqdgapLQVCVDGEChilgr 944  human

CAB57274   911 --------hdalVEVCVRDcsp---------------hyrALSPKrFTFVT 938  human
JC5148     712 ---------tylVALKIDNa-------------------nRESSTrFTYME 734  African clawed frog
P16056     718 ---------efpVKLKIDLa--------------------NRETSsFSYRE 739  house mouse
T30809     727 ---------dvpLSVFIDKs-------------------pILTTKvFYYKE 749  torafugu
CAA58863   719 ---------eyrVRVGIDGa-------------------iRDAKGyFTYRE 741  chicken
NP_524616 1165 tf----kktnrkMDTELHLqnssfqtetrykneydrkkrrADFGDtFRLYT 1211 fruit fly
BAA31595  1194 ---------sapVDFFINGrayadevava-eelldpeeaqRGSRFrLDYLP 1234 human
P51805    1090 qp---raqgehpDEFGFLLdhvq--------------tarSLNRSsFTYYP 1123 human
AAC18823   817 ---------kvrTNVTVKLrvq----------------dtYLDCGtLQYRE 842  human
Q04912     945 vvrpgpdgvpqsTLLGILLplll-------------lvaaLATALvFSYWW 982  human
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