1A3Q,1IMH,1A02,1NFI,1NFI


Conserved Protein Domain Family
IPT_TF
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cd00602: IPT_TF 
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IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.
Links
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Statistics
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PSSM-Id: 238336
Aligned: 27 rows
Threshold Bit Score: 87.7226
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:DNA binding interface varies between IPT transcription factor members
  • Structure:1A3Q_A; NF-kappaB - DNA contacts
  • Citation:PMID 9384586
  • Structure:1A02_N; NFAT- DNA contacts
  • Citation:PMID 9510247
  • Structure:1IMH_C; TonEBP - DNA contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ## #                                                     
1A3Q_A     186 LKISRMDKTAGSvrGGDEVYLLCDKVQk-dDIEVRFYedd---engWQAFGDFSptdvhkqyAIVFRTPPYHKmki--er 259  human
1A02_N     201 PMVERQDTDSCLvyGGQQMILTGQNFTs--ESKVVFTekttdgqqiWEMEATVDkdks-qpnMLFVEIPEYRNkhi--rt 275  human
BAB85496   576 PQVEKYSVNSCSvnGGLELVITGSNFMp--DSKVIFLekgqdgcthWEAEGKIVlkkc-qmnNIVVEIPAYHNksv--aa 650  African clawed frog
Q14934     586 PQVEAYSPSACSvrGGEELVLTGSNFLp--DSKVVFIergpdgklqWEEEATVNrlqs-nevTLTLTVPEYSNkrv--sr 660  human
Q12968     600 PHIEKYSINSCSvnGGHEMVVTGSNFLp--ESKIIFLekgqdgrpqWEVEGKIIrekc-qgaHIVLEVPPYHNpav--ta 674  human
O02019     383 TPVPVVHSLQLNg-GGDVAMLEVNGENfspQLKVWFGe--------VEADTMYRcee--gllCVVPDISEFREgwtwvkq 451  Halocynthia roretzi
P28159     426 TPVPIVNSLNLNg-GGDVAMLELSGDNftpHLQVWFGd--------VEAETMYRcte--tllCVVPEISQFRGewlwvrq 494  fruit fly
Q91880     353 TPVPVVESLQLNg-GGDVAMLELTGQNftpNLRVWFGd--------VEAETMYRcae--smlCVVPDISAFREgwrwvrq 421  African clawed frog
BAC99044   448 TPVPLVSDLHLNg-GGDVAMLELRGENftpDLKVWFGc--------VEAETMYRnnd--cmlCVVPDISALCGewryiqr 516  Hemicentrotus pu...
O08674     381 TPVPLISTLELSg-GGDVATLELHGENfhaGLKVWFGd--------VEAETMYRspr--slvCVVPDVAAFGSdwrwlrt 449  house mouse

Feature 1                   #            
1A3Q_A     260 PVTVFLQLKRkrgGDVSDSKQFTYYP 285  human
1A02_N     276 PVKVNFYVINg-kRKRSQPQHFTYHP 300  human
BAB85496   651 EVQVQFYVCNg-kRKRSQSQRFNYTP 675  African clawed frog
Q14934     661 PVQVYFYVSNg-rRKRSPTQSFRFLP 685  human
Q12968     675 AVQVHFYLCNg-kRKKSQSQRFTYTP 699  human
O02019     452 SVQVPINLVRhdgIIYPTNLTFTFTP 477  Halocynthia roretzi
P28159     495 PTQVPISLVRndgIIYATGLTFTYTP 520  fruit fly
Q91880     422 PVQVPVTLVRndgVIYSTSLTFTYTP 447  African clawed frog
BAC99044   517 PTQVNIMLVRqdgIIYPTGRMFTYTP 542  Hemicentrotus pulcherrimus
O08674     450 PITVPVSLLRadaLFYPSPFSFTYTP 475  house mouse

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