1JFX,1OBA,2NW0,1SFS


Conserved Protein Domain Family
GH25_muramidase

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cd00599: GH25_muramidase 
Click on image for an interactive view with Cn3D
Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.
Statistics
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PSSM-Id: 119373
View PSSM: cd00599
Aligned: 45 rows
Threshold Bit Score: 90.8708
Threshold Setting Gi: 46015792
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                          #                                                 
1JFX_A         6 QGIDVShwqgsin---wssvksaGMSFAYIKATEGtny-----------------------kdDRFSANYTNAynag--- 56   Streptomyces c...
AAS57574       3 KMVDVFsgsprs------fatlpETDITMVKATQGigy-----------------------vnPACNIDYANAkaag--- 50   Lactobacillus ...
BAG06149     774 YFIDISshngiisvaefnslkqqGIQGVVVKLTEGtsy-----------------------inPYASSQIANAraag--- 827  Streptococcus ...
XP_001952340 341 VVIDLShwnvnvd---fgmaksnGTVAVIHKATQGirn-----------------------idSCYRTRRIAAekeg--- 391  pea aphid
NP_107763     24 LVVDAYeynsidw---gqlatdkRIAAFINKASDGmpppyfcfgsdndvklckalwkrhavtrELFQTRRVVAkalg--- 97   Mesorhizobium ...
ZP_02845164   10 KIIDVShhqglin---waavksdGVQGAFIKATEGrti-----------------------ldDKLEVNSKGAaeag--- 60   Paenibacillus ...
NP_562230     10 FGPDLNefsrdvn----fltlakNSDFIYLRASGSgtg-----------------------klRIDNKFLEFAkecrrlg 62   Clostridium pe...
ZP_03127883   24 SILSLShydertsd--fsgmqrgGLEAIIHEATYPaye-----------------------ddAKYAYRQAEAmrag--- 75   Chthoniobacter...
YP_001315006 159 VVLDPYkgnsidw---nmvktdpRVAAVIHKASQGmt------------------------sdQKYAERKKVAtklg--- 208  Sinorhizobium ...
YP_078670      4 KGIDVShwqgnin---wkkvagdGIKFAFIKATEGttl-----------------------qdNKFVTNISGAnavg--- 54   Bacillus liche...
Feature 1             # #                                         # #                            
1JFX_A        57 iirGAYHFarpn--assGTAQADYFASNgggwsr------dnrtlPGVLDIEhnpsgamcyglsttqmRTWINDFHARYK 128  Streptomyces c...
AAS57574      51 kllGLYHYcag----gnPIAEADYFINNikny---------vgeaVLAVDWEgyqns-------swgnYNYVRQFVNRVH 110  Lactobacillus ...
BAG06149     828 ikvSAYHYahyt-saagAQEEARYFANAarsfg-------leastVMVNDMEessm--------vnniNNNVQAWQDEMR 891  Streptococcus ...
XP_001952340 392 llwGAYHFgtn----tnGVIQANHFLNQvgnt----------satLLVLNVEpykn--------nimtQKQVEDFIKTVQ 449  pea aphid
NP_107763     98 mkwGAYHLarp----gnPVEQANNFLDFadpa----------pddLMALDIEgidps-------qwmsLDDAEEFVRQVH 156  Mesorhizobium ...
ZP_02845164   61 laiGFYHYahpe--nndPLVEAAWFANAlkgf---------aaqfPHVLDVEgkastv-----ggeqlSKWCLAWLQEVE 124  Paenibacillus ...
NP_562230     63 ipcGAYHFakpskdldsAVIQADQFIDVlqqgfgd----gdygdlFPVLDVEtptdks----ltttelVNWIDRFRDRFE 134  Clostridium pe...
ZP_03127883   76 llwGAYHFgng----tdGRKQADHFISFvgakwvtghsasqpsgvLLVLDAEqnthyp-----ggnmnVEQAVRFIERVH 146  Chthoniobacter...
YP_001315006 209 yawGSYHLltt----anVTQQIDHYLSIvgde----------akeSRAIDVEclggttscqsgsfkvsFASIEAALRRVK 274  Sinorhizobium ...
YP_078670     55 iktGAYHFarfg-skseALAEARFFLSVankv---------hltyPLVLDLEvnqrnv-----sksvlTDAAVAFLREVE 119  Bacillus liche...
Feature 1                 #                            #                              #          
1JFX_A       129 ARttrDVVIYTTASWwntctgsw------ngmaakspFWVAHwgvsapt---------vpsgfptWTFWQYSAtgrvg-- 191  Streptomyces c...
AAS57574     111 ELtgvWCMVYVSQSEirqvan----------cindcpLWVAYykysqplnwdyqgagfniapwevFTIHQFTGs------ 174  Lactobacillus ...
BAG06149     892 RQgysNLIHYTMASWldirggqvy-----tarfginnFWVAHyakgytymtqe--eakslnyyanAAAWQYTSvssk--- 961  Streptococcus ...
XP_001952340 450 NItnnFVMIYASYNTlknystp---------fllktpLWIALyntqlkl----------ppgwdkWVLWQYTDgkkglwp 510  pea aphid
NP_107763    157 RRvgrFPVLYTNGKTaqyiadnry----kyrllsrlpLWYARykpdidvh-------fpmgnwqgYALWQFSAqancgrf 225  Mesorhizobium ...
ZP_02845164  125 RLtghPTMIYSGASFaktylnk---------qvasfpLWIAHygvetpm---------pnstwdkWCVFQYTSsgnvk-- 184  Paenibacillus ...
NP_562230    135 EKtrrRLMLYTGLFFiglyddfkvp--gkgyplsdmpLWIAMytripsnpri----ppnvggwkrWTMWQFTDegkld-- 206  Clostridium pe...
ZP_03127883  147 ERtgiYPGLYSNENWlkkvfgdpsissnsretlkkcwLWIANyhkqpas----------tavwdrWTLWQYTGdgvcglp 216  Chthoniobacter...
YP_001315006 275 EKtghFPLLYANHSVattlsarwk----dssefadvrLWYARfkknvtdf--------ptgpwksYTLWQFSSeinctps 342  Sinorhizobium ...
YP_078670    120 KAg-yFAMIYSGKSFlenclde--------sklkpfaLWVARynnt---------------lgrhADIWQYSDcgrva-- 173  Bacillus liche...
Feature 1                      #    
1JFX_A       192 --------gvsgdVDRNKF 202  Streptomyces coelicolor
AAS57574     175 ------------dMDRNMV 181  Lactobacillus fermentum
BAG06149     962 ---------lshaLDENID 971  Streptococcus mutans
XP_001952340 511 h-----gvngvglCDRDKF 524  pea aphid
NP_107763    226 rcp-yrvagtpnnIDVNVV 243  Mesorhizobium loti MAFF303099
ZP_02845164  185 --------giagkVDINAM 195  Paenibacillus sp. JDR-2
NP_562230    207 --------gvgspVDLNWG 217  Clostridium perfringens str. 13
ZP_03127883  217 rrsyptsflsmrkVERTIF 235  Chthoniobacter flavus Ellin428
YP_001315006 343 scp-yrvpgtqrdMDLNIY 360  Sinorhizobium medicae WSM419
YP_078670    174 --------gisgnVDMNIC 184  Bacillus licheniformis ATCC 14580

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