1HKK,1NH6,2UY2,1EOM,1JND,2DSK,3CO4,3CZ8,1NAR,1E6Z,3B9A,1LL4,1WAW


Conserved Protein Domain Family
GH18_chitinase-like

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cd00598: GH18_chitinase-like 
Click on image for an interactive view with Cn3D
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.
Statistics
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PSSM-Id: 119349
View PSSM: cd00598
Aligned: 57 rows
Threshold Bit Score: 78.1884
Threshold Setting Gi: 9955018
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1NH6_A; Serratia marcescens chitinase A binds hexasaccharide
    View structure with Cn3D
  • Structure:1E6Z_A; Serratia marcescens chitinase B binds allosamidin
    View structure with Cn3D
  • Structure:3B9A_A; Vibrio harveyi chitinase A binds hexasaccharide
    View structure with Cn3D
  • Structure:1LL4_D; Coccidioides immitis chitinase 1 binds Allosamidin
    View structure with Cn3D
  • Structure:2UY2_A; Saccharomyces cerevisiae CTS1 endochitinase binds 2 glycerol molecules
    View structure with Cn3D
  • Structure:1HKK_A; Human macrophage chitotriosidase binds allosamidin
    View structure with Cn3D
  • Comment:Allosamidin is thought to resemble the structure of a reaction intermediate that is unique among the glycoside hydrolases.
  • Structure:1WAW_A; Human macrophage chitotriosidase binds argadin, a chitinase inhibitor
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                                #                                            
1HKK_A         4 VCYFTNwaqyrqgear--flpkdldpslCTHLIYAFAGmtnhqlst---------------------------------- 47  human
1NH6_A       137 VGSYFVewgvygrnf----tvdkipaqnLTHLLYGFIPicggngindslkeiegsfqalqrscqgredfkvsihdpfaal 212 Serratia marces...
2DSK_A        12 FAPYIDmslsvhkpl-----veyakltgTKYFTLAFILyssvyngpaw-------------------------------- 54  Pyrococcus furi...
1NAR_A         5 FREYIGvkpnsttlhdf-pteiintetlEFHYILGFAIesyyesgkgtgt------------------------------ 53  Vicia narbonensis
AAO88269      18 VICYYQtyypnngtdyistlplltndcgVSHIILAAIHindepgnitlnd------------------------------ 67  Coccidioides po...
AAM80487     131 MMGGYLddrfiqgsv-----vqtpyafyHWQCIDVFVYfshht------------------------------------- 168 human
XP_001018441  12 SIAYINsvnkwwgadi--iydsfglnsnYDIIILSFWLsqqgafdavklyetiy------------------------qn 65  Tetrahymena the...
XP_001010440  54 KIAYINqlsewdgpki--ldamglnspcYNVFILTFWMpgwvsdalsvwenist-------------------------y 106 Tetrahymena the...
XP_001022833  85 KIAYVDtmkswwgpsi--itdsfglnscYDIIILSFWLtygtadaanlyeniyt-------------------------y 137 Tetrahymena the...
EAL20834     312 YVIYADrwlsamp--------dvselssFNRFILAFWEsnggavddvq-------------------------------- 351 Cryptococcus ne...
Feature 1                                                                                        
1HKK_A        48 ------tewndetlYQEFNGLKkmn---pkLKTLLAIGGwnfgtqkf--tdmvatanNRQTFVNSAIRFlrk------ys 110 human
1NH6_A       213 qkaqkgvtawddpyKGNFGQLMalkqahpdLKILPSIGGwtlsdpf----ffmgdkvKRDRFVGSVKEFlqt-----wkf 283 Serratia marces...
2DSK_A        55 -----agsiplekfVDEVRELRei-----gGEVIIAFGGavgpyl-------cqqasTPEQLAEWYIKVidt------yn 111 Pyrococcus furi...
1NAR_A        54 ---feeswdvelfgPEKVKNLKrrh---peVKVVISIGGrgvntpf----dpaeenvWVSNAKESLKLIiqkysddsgnl 123 Vicia narbonensis
AAO88269      68 ---hspddpryvplWAEMRVMQas-----gTKVMGMVGGaakgsy-------qrldgSVADFEAFYCPLrdmi---rtrn 129 Coccidioides po...
AAM80487     169 ---------vtippVGWTNTAHrh-----gVCVLGTFITewneggrlceaflagderSYQAVADRLVQItqf------fr 228 human
XP_001018441  66 lgteqfgcsnsevqKNILDLFHqk-----qKKLFIAAFGgtdfp---------tsqnPLDVANKLSDWIksn------py 125 Tetrahymena the...
XP_001010440 107 isttkygktdaeiqKKILELFHaq-----gKQLFISAFGgtdnp---------tgsdPVQIASQLADFVnrn------py 166 Tetrahymena the...
XP_001022833 138 lgtdqygknntevqKNISDLFHsk-----gKQLFISAFGstnf----------ptsqDPIAVANKLADWvqk-----npy 197 Tetrahymena the...
EAL20834     352 ----awsswdegyrRQIIEEYHda-----gIAIMIAAFGstdqp--------ttsgaDAKQVAQKLASFvme------yn 408 Cryptococcus ne...
Feature 1            # # #                                                                       
1HKK_A       111 FDGLDLDWEYPgsqgsp-----avdkerFTTLVQDLANAFqqeaqtsgkerlLLSAAVpagqtyvda--------gyevd 177 human
1NH6_A       284 FDGVDIDWLFPggkganpnlgspqdgetYVLLMKELRAMLdqlsve-tgrkyELTSAIsagkdkidk---------vayn 353 Serratia marces...
2DSK_A       112 ATYLDFDIEAGida------------dkLADALLIVQRERpw---------vKFSFTLpsdpgiglaggy---giietma 167 Pyrococcus furi...
1NAR_A       124 IDGIDIHYEHIrsd------------epFATLMGQLITELkkddd---lninVVSIAPsennsshyq---------klyn 179 Vicia narbonensis
AAO88269     130 LNGLDLDVEEDmsl------------dgIIRLIDRLKSDFgd--------efIITLAPvatamvrglrhlsgfdyralet 189 Coccidioides po...
AAM80487     229 FDGWLINIENSlsla---------avgnMPPFLRYLTTQLhrqvp---gglvLWYDSVvqsgqlkwqd------elnqhn 290 human
XP_001018441 126 IDGVDIDYEDNeailng------tgvqwLIAFQQQIRFRLgn--------kyIITHAPqapyfskqyyqg--ggyynlhk 189 Tetrahymena the...
XP_001010440 167 IDGVDIDYEDNdaivng------tgvtwLITFQKALAEKInnk-------niIFTHAPqapyfsrayydn--gayytieq 231 Tetrahymena the...
XP_001022833 198 IDGIDIDYEDNdavvng------sgiswLITFQKQLRARIgn--------nyLITHAPqapyfsrayynd--ggyykldq 261 Tetrahymena the...
EAL20834     409 LDGVDIDYEDMsamnsa------qavswIVELQMELRNLLps--------pyIISHAPvapwftsandysd-gsyvsihq 473 Cryptococcus ne...
Feature 1                     ##                                                       #         
1HKK_A       178 kiaqNLDFVNLMAYDfhgswekvtghnsplykrqeqsg--aaaslnvdaavqqwlqkgtpaskLILGMPTYgrsftlass 255 human
1NH6_A       354 vaqnSMDHIFLMSYDfygafdlknlghqtalnapawkp---dtayttvngvnallaqgvkpgkIVVGTAMYgrgwtgvng 430 Serratia marces...
2DSK_A       168 kkgvRVDRVNPMTMDyywtpsnaenaikvaenvf-----------rqlkqiypeksdeeiwkmIGLTPMIGvnddks--- 233 Pyrococcus furi...
1NAR_A       180 akkdYINWVDYQFSNqqkpvstddafve----------------------ifkslekdyhphkVLPGFSTDpldtkhn-- 235 Vicia narbonensis
AAO88269     190 argsKISWYNVQFYNgrghmlhpsvyd-------------------------tiihqgweaerIVIGLLTNpangsq--- 241 Coccidioides po...
AAM80487     291 rvffDSCDGFFTNYNwreehlermlgqagerradvyvgvdvfargnvvggrfdtdkslelirkHGFSVALFapgwvyecl 370 human
XP_001018441 190 qvgnSIDWYNIQFYNqgdsntydsfeklfvcsgpp---------fletsyreiiqinqipiekLVLGKPATkqdvynt-- 258 Tetrahymena the...
XP_001010440 232 evghLISWYNVQFYNqesdsydsyeklflnsgap----------fvntsyqeiiekdkipiskLVLGKPATpkdadnt-- 299 Tetrahymena the...
XP_001022833 262 qvgsLIDWYNVQFYNqgddsydsltklfvqsgsp----------fvgtsyseiiqndgipiskIYLGKPATtadlsnt-- 329 Tetrahymena the...
EAL20834     474 qvgdSIDFYSVQFYNqgpdqyvscetlitdsgse----------wpstsvfeinshagvpldkIVIGKPLEpgsasn--- 540 Cryptococcus ne...
Feature 1                                                                                        
1HKK_A       256 sdtrvgapatgsgtpgpftkeggmlay----yevcswkgatkqriqdqkvpyifrdnqwvgfddveSFKTKVSYLKQk-- 329 human
1NH6_A       431 yqnnipftgtatgpvkgtwengivdyrqiasqfmsgewqytydataeapyvfkpstgdlitfddarSVQAKGKYVLDk-- 508 Serratia marces...
2DSK_A       234 -------------------------------------------------------------vftleDAQQLVDWAIQh-- 250 Pyrococcus furi...
1NAR_A       236 ------------------------------------------------------------kitrdiFIGGCTRLVQTf-- 253 Vicia narbonensis
AAO88269     242 ------------------------------------------------------------gyvpmeTISSVLANVLTky- 260 Coccidioides po...
AAM80487     371 ekkdffqnqdkfwgrleryl-----------------pthsicslpfvtsfclgmgarrvcygqeeAVGPWYHLSAQe-- 431 human
XP_001018441 259 ------------------------------------------------------------gyvnpyDLGKIIRYAEInlq 278 Tetrahymena the...
XP_001010440 300 ------------------------------------------------------------gyvepaELGKICTEAQQklg 319 Tetrahymena the...
XP_001022833 330 ------------------------------------------------------------gyvdpaTLGSLVYQAQTtlg 349 Tetrahymena the...
EAL20834     541 ------------------------------------------------------------gymsasDLHQCVSEAKErg- 559 Cryptococcus ne...
Feature 1                #     
1HKK_A       330 -gLGGAMVWALDLD 342 human
1NH6_A       509 -qLGGLFSWEIDAD 521 Serratia marcescens
2DSK_A       251 -kIGSLAFWSVDRD 263 Pyrococcus furiosus
1NAR_A       254 -sLPGVFFWNANDS 266 Vicia narbonensis
AAO88269     261 psFGGVSGWEYFNA 274 Coccidioides posadasii
AAM80487     432 -iQPLFGEHRLGGD 444 human
XP_001018441 279 fqVPAFFIWQLKSD 292 Tetrahymena thermophila SB210
XP_001010440 320 ynIPGFFIWEFIND 333 Tetrahymena thermophila SB210
XP_001022833 350 lkVPGFFIWQLKND 363 Tetrahymena thermophila SB210
EAL20834     560 -wNAGVMFWEWSEE 572 Cryptococcus neoformans var. neoformans B-3501A

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