1JEY,1JEY,1JEQ,1JEQ


Conserved Protein Domain Family
KU
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cd00594: KU 
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Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen recognized by the sera of patients with an autoimmunity disease. In eukaryotes, the Ku heterodimer contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by non-homologous end-joining. The bacterial Ku homologs does not contain the conserved N-terminal extension that is present in the eukaryotic Ku protein.
Links
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Statistics
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PSSM-Id: 238334
Aligned: 128 rows
Threshold Bit Score: 109.669
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingheterodimer
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1JEY; Ku heterodimer binds DNA; defined at 4A contacts
  • Comment:Members of this family bind to double-strand breaks. Ku70 and Ku80 bind DNA in a partially symmetrical manner.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #                                                    #                         
1JEY_A    254 RALSRLKLKLNKd---------------------------------IVISVGIYNl--VQKALKp--------------- 283 human
XP_710203 330 RIQFTCDLILSDngki---------------------------gggFGCTVKGYMl--YSHEKIn--------------- 365 Candida albicans S...
CAG89149  285 RILFSCDLILGDgegv---------------------------sgnFGCSVKGYTi--YNHEKLk--------------- 320 Debaryomyces hanse...
CAA49840  265 RIMFQCPLILDEkt-------------------------------nFIVGVKGYTm--YTHEKAg--------------- 296 baker's yeast
NP_982830 247 RAYFSCPLVINKta-------------------------------dLVVSVAGYVa--TTHERPg--------------- 278 Eremothecium gossypii
AAX80670  321 GASQTTTLTIGVgakg---------------------------salPRLTVGMYFp--MTNAQRr--------------- 356 Trypanosoma brucei
AAS53814  264 RLRYSCPLFLNEeq-------------------------------gLVVSVKGYAa--TTYERPg--------------- 295 Ashbya gossypii AT...
CAH01326  267 RIKFRCPLMLDEra-------------------------------dLVVSVNGYTi--VSHEIPg--------------- 298 Kluyveromyces lact...
CAG60303  274 RVVFQCPLVLDEgt-------------------------------nFVISIKGYSi--FNHEKGs--------------- 305 Candida glabrata C...
XP_975296 139 FYKRTIIFITNDdnpvrgdknqrfaalneaknfesnditfelvtmkPNFDYKIFYnelFSIIKSppvetvvededglfek 218 red flour beetle

Feature 1             #                      #                                                
1JEY_A    284 -------pPIKLYr----eTNEP----VKTKTRTFNtst-----------ggLLLP-----------------SDTKRSQ 320 human
XP_710203 366 -------rNELLLy-----TRSEtlkrVFSSSKLMQng-------------kAIEIakdtgks---yqdrkeeAGIRKGF 417 Candida albicans S...
CAG89149  321 -------kFNKIYn-----SGEElk-iVHTRSKILNd--------------rTGEKvevetkgnqsvternedANIRKGF 373 Debaryomyces hanse...
CAA49840  297 -------vRYKLVy-----EHEDirqeAYSKRKFLNp--------------iTGEDv---------------tGKTVKVY 335 baker's yeast
NP_982830 279 -------tRYKYIv-----KHDGrtksVHQCRKYKTvdn-----------ekYIRD-----------------ADRSSVY 318 Eremothecium gossypii
AAX80670  357 -------lSKWLDg----rAGEM----VMLRQRAVGvgapill---pchagkSGAPp----------------AHISTGQ 402 Trypanosoma brucei
AAS53814  296 -------aRYRMVy-----QHEDvqreAFSHRRYLDp--------------dTGEEa---------------tEDLCKVY 334 Ashbya gossypii AT...
CAH01326  299 -------sKYKLVy----aNGSVrr-eAYSHREYLDa--------------eTGEAvd--------------nSQLSKVY 338 Kluyveromyces lact...
CAG60303  306 -------vRYKLVy-----ENQEirkeAFSKRKFINp--------------kTGEDv---------------sKQTVKII 344 Candida glabrata C...
XP_975296 219 lsssvvrrFYQRRllffpfANDQtr-fLKIRQKSFVqeerlynnasvsesgkLLKKvsk------------tvNDSIETY 285 red flour beetle

Feature 1                                                                                     
1JEY_A    321 IYG---------SRQIILEKeeteel------------------------------------------------krfddP 343 human
XP_710203 418 EIGg-------gQDIIILNKqqlefltnysfdhrlkdsddednedgndsletdisddddeeggaggtggetkpvsfskpP 490 Candida albicans S...
CAG89149  374 PIGndhv-lylnSKQINFLKnyafdhnsdnraggnseded--------------------ddefdnqnedlddhgfskpP 432 Debaryomyces hanse...
CAA49840  336 PYG---------DLDINLSDsqdqivm---------------------------------------------eaytqkdA 361 baker's yeast
NP_982830 319 WIG---------GAGIEVTDaelrkmt---------------------------------------------rgcskyeS 344 Eremothecium gossypii
AAX80670  403 LGKsrpstgpgtCPNVPLSCkkhiaev----------------------------------------------vgagltL 436 Trypanosoma brucei
AAS53814  335 QIG---------DDCLDLPDdlenlitn--------------------------------------------faaptsdS 361 Ashbya gossypii AT...
CAH01326  339 TFG---------DEIIELTEdenlkiq---------------------------------------------sgyseheS 364 Kluyveromyces lact...
CAG60303  345 PYG---------EKEIEMEDknianal---------------------------------------------nvygntsA 370 Candida glabrata C...
XP_975296 286 KLDy-------eLGSLEFSVserfki-----------------------------------------------rntdlpI 311 red flour beetle

Feature 1                                                                           #         
1JEY_A    344 GLMLMGFKPLV-LLKKHHYLrpSLFVYPEesl----------viGSSTLFSALLIKCLEKEVAALCRYTPRrnipPYFVA 412 human
XP_710203 491 YLKLIGFRDIS-HFSPVYSCgaPIFVTPDvdngmissavtggftNSFKTFASLYRSCVKLNQYAIVLGCTRsnsrPRLYA 569 Candida albicans S...
CAG89149  433 YLKLLGFRSLS-TYQPHYNSsaPIFVTPDmndglktasaeggykNSFKTFSSLYQSCIKLQKYGVLFGCLKknsmPNLYA 511 Debaryomyces hanse...
CAA49840  362 FLKIIGFRSSSkSIHYFNNIdkSSFIVPDeak----------yeGSIRTLASLLKILRKKDKIAILWGKLKsnshPSLYT 431 baker's yeast
NP_982830 345 FLEILGFRAINtAAPYYSNIgrAYYILPRelp----------fsGSAKVLASLNRSMFEKGKAAIVWGQLKagfhPTLFA 414 Eremothecium gossypii
AAX80670  437 GFSIICFKNADdVLHPQYVLgkSCVLHPDpqd---------gsdGSLRLFIRLARALKEQRKVAMAQHITRyatpPRLVA 507 Trypanosoma brucei
AAS53814  362 FLRMLGSRTAVaVLPYYNNIhhVTFLVPDdsv----------yaGSAAVLASLHRTLRASQRAVVLYGKLRatslPALYA 431 Ashbya gossypii AT...
CAH01326  365 FLKLIGFRSTEqCLHYYDNIdvPAFVVPNeed----------yaGSIKTLASLYRTMLFKKKSAMVWGKLRpnspPSMFV 434 Kluyveromyces lact...
CAG60303  371 SLTVIGFLNEDnSLVFYNNIdkTLFITPDenv----------ieGSFTAFASLFRTLKKLKKVGVVWGSTKsnssPSLYL 440 Candida glabrata C...
XP_975296 312 GYTLVQVSDRV-TDVGIVLTn-PVIIEVDp-------------kEELDLFASFWQYCVEKNKVLVCFRKLKkldkICFVE 376 red flour beetle

Feature 1                                                                                     
1JEY_A    413 LVPQEeelddq---------------kiqvtpPGFQLVFLPFADDKRK-MPFTEKim----------aTPEQVGKMKAIV 466 human
XP_710203 570 LYPTHttnssknplpknlddevdnddnqdefpQGFLLIKLPWLEDVRAlPGEYIKntqre----eihnDDTLIDNFKQLL 645 Candida albicans S...
CAG89149  512 LYPTKatnsnk---------------sglnfpEGFFLIRLPWLDDVRSlPEYSFLnnvnlnelsgesvPPEILLNFKHII 576 Debaryomyces hanse...
CAA49840  432 LSPSSvkd----------------------ynEGFYLYRVPFLDEIRKfPSLLSYddgs-----ehklDYDNMKKVTQSI 484 baker's yeast
NP_982830 415 LIPSDge------------------------tCALRLVRIPFIEEVRCfPTLDGEdrlf------htrEYELVKTVSQNL 464 Eremothecium gossypii
AAX80670  508 LVPPGlngdhmdt-----------asfpvmhgLGLYVVPLSYADDVRTtPRSPLFgda-------tkpMERDIALAQRLL 569 Trypanosoma brucei
AAS53814  432 LAPAAapl----------------------pdAVFILARLPFQEEVRKfPALSPPqasl------aspDYAVLQKITSRI 483 Ashbya gossypii AT...
CAH01326  435 LTPSSkkd----------------------ynQGFYLYKVPFMEEVRKlPDFLNHsali------esdDYKVMSKVTETL 486 Kluyveromyces lact...
CAG60303  441 LWPSKddd----------------------nnQGFYLTKVPFIDEIRKyPTLSNInine------eweEYKNVKELTQGI 492 Candida glabrata C...
XP_975296 377 FIPKFmn-----------------------nsRVFVAKTIPFNDDHQPiPSALASeepn------esfSKKMLQTTNELI 427 red flour beetle

Feature 1                                                                                     
1JEY_A    467 EKLRf---tYRSDSFENPvLQQHFRNLEALALdlmepeqavdl---------------tlpkveamnkRLGSLVDEFKEL 528 human
XP_710203 646 PKFEls--hYDPREFPNAsLNYFYKVIKHEILqmelkpsqrpl--------------menditmqklaQLKNSINNDDTA 709 Candida albicans S...
CAG89149  577 SQFFlr--eYRPLDFPNPsINYFYKIINNELLqeelspesktvann--------dtttqklielrgylQQEELQTMLKTL 646 Debaryomyces hanse...
CAA49840  485 MGYFnlrdgYNPSDFKNPlLQKHYKVLHDYLLqiettfdenetp------------ntkkdrmmreddSLRKLYYIRNKI 552 baker's yeast
NP_982830 465 IRHFslrtsYRPSDIRNPlLRNFYSTLYHEQSqdakrkmpelqylp--------esdstlhkvqlvrdRIENSIIHDEPP 536 Eremothecium gossypii
AAX80670  570 ATLPs---kYNVNVVPNPaLELRYKAIESIVQqtqqqsglskeipgvapfsqlskavdrtwgdrgamaKYGSVFDEFKAV 646 Trypanosoma brucei
AAS53814  484 IDLLvlsspYAPADFKNPvIATHFRLLSDHLFetaqdprtddtiar--------llrlrhrvlddpesRLAKYLRHWNAF 555 Ashbya gossypii AT...
CAH01326  487 INFFnlkngYRPSDFHNPaLQKHFKILREYLLqievdkskpedeg-----------detlqkvkqiyaRIASSAKSDDVK 555 Kluyveromyces lact...
CAG60303  493 ISHFnlksgYHAEEFRNPaLNRHYKLLHDYLLqveipqddndirdry------lreddtllkitkireRIMKDTTIDDVE 566 Candida glabrata C...
XP_975296 428 DNLTf---dYDPKMFTNPsLTKKKAYLRSKLLeepqedvedv-----------------sldsaaidkRLGDLGASFKML 487 red flour beetle

Feature 1      
1JEY_A    529 V 529 human
XP_710203 710 I 710 Candida albicans SC5314
CAG89149  647 N 647 Debaryomyces hansenii CBS767
CAA49840  553 L 553 baker's yeast
NP_982830 537 I 537 Eremothecium gossypii
AAX80670  647 L 647 Trypanosoma brucei
AAS53814  556 Y 556 Ashbya gossypii ATCC 10895
CAH01326  556 Q 556 Kluyveromyces lactis NRRL Y-1140
CAG60303  567 K 567 Candida glabrata CBS 138
XP_975296 488 F 488 red flour beetle

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