1IHO,2EJC,1UFV,3INN,1N2B


Conserved Protein Domain Family
PanC
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cd00560: PanC 
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Pantoate-beta-alanine ligase
PanC Pantoate-beta-alanine ligase, also known as pantothenate synthase, catalyzes the formation of pantothenate from pantoate and alanine. PanC belongs to a large superfamily of nucleotidyltransferases that includes , ATP sulfurylase (ATPS), phosphopantetheine adenylyltransferase (PPAT), and the amino-acyl tRNA synthetases. The enzymes of this family are structurally similar and share a dinucleotide-binding domain.
Links
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Statistics
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PSSM-Id: 185673
Aligned: 49 rows
Threshold Bit Score: 332.191
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1N2B, Mycobacterium tuberculosis pantothenate synthetase with bound AMPcpp and pantoate, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 ####  # ##  #                      #  #         #   
1IHO_A      1 MLIIETLPLLRQQirrlr-megkRVALVPTMGNLHDGHMKLVDEAKAra-----dVVVVSIFVNPMQFDRPEDLARYPRT 74  Escherichia coli
1N2B_A     11 LNVYSAPGDVADVsralr-ltgrRVMLVPTMGALHEGHLALVRAAKRvp----gsVVVVSIFVNPMQFGAGGDLDAYPRT 85  Mycobacterium tube...
NP_893707   3 KIIIRKTEDLKEWrrn----lkcDINFIPTMGNLHDGHQKLISTAQSsn----cnTNLLSIFVNPLQFDSKEDLKSYPKT 74  Prochlorococcus ma...
Q9FKB3      3 PEVIRDKDSMRKWsramr-sqgkTIGLVPTMGYLHEGHLSLVRQSLAlt-----dVTVVSIYVNPGQFSPTEDLSTYPSD 76  thale cress
P57292      1 MHIIKTIKVLYKEikilk-ksnkKIGLVPTMGNLHDGHIKLILLAKKys-----dIIIVSIFINPMQFDNLSDLKNYPKT 74  Buchnera aphidicol...
NP_876137   3 LTILRTKTALEDWcrqk---hnhEINFVPTMGGLHQGHQELIKTARSfckrkhssQVLVSIFINPLQFDLEEDFKKYPRT 79  Prochlorococcus ma...
NP_859566   1 MRVIQSICEMRHYragi--andkTIGFVATMGALHQGHLSLMKASLAen-----dYTIVSIFVNPTQFGANEDFGAYPRT 73  Helicobacter hepat...
CAD73378    1 METFTSIDAMRAWcreks-rggnTIGLVPTMGALHEGHLSLVHAAKKdc-----dHCVTSIFVNPTQFAANEDLDQYPRP 74  Pirellula sp. 1
P56061      1 MRVLETIVALREYrks----leeSVGFVPTMGALHKGHQSLIERSLKen-----sHTIVSVFVNPTQFGANEDFNAYPRP 71  Helicobacter pylori
NP_871451   1 MLIIKKSSELTCViknlkkknksKIALIPTMGNLHRGHLELIKIGKLks-----nILIISIFINPAQFSNSKDFRNYPKT 75  Wigglesworthia glo...

Feature 1                                                                                    #
1IHO_A     75 LQEDCEKLNKRKVDLv--FAPSVKEIYPngt----------------------ethTYVDVPGLSTMLEGASRPGHFRGV 130 Escherichia coli
1N2B_A     86 PDDDLAQLRAEGVEIa--FTPTTAAMYPdg------------------------lrTTVQPGPLAAELEGGPRPTHFAGV 139 Mycobacterium tube...
NP_893707  75 VDKDIEIAFSNGADAi--FIPNVTDIYPkknk---------------------sisYLKASKELSSALCGLTRVGHFDGV 131 Prochlorococcus ma...
Q9FKB3     77 FSGDLTKLAALSGGKvvvFNPKNLYDYGgetkkindgggnggrvvscveegglgheTWIRVERLEKGFCGKSRPVFFRGV 156 thale cress
P57292     75 FMKDSIILKKYHVDIl--FFPHINEIYPngi----------------------ehqTFVEVIKLSKILEGQSRPGHFRGV 130 Buchnera aphidicol...
NP_876137  80 FENDCKIAYEAGANAi--WAPSFESVFPngee---------------------ahfKIQVPFSLNKYLCGASREGHFDGV 136 Prochlorococcus ma...
NP_859566  74 LEADIALCERVGVSAi--FAPSIDDMYEdd------------------------evGFSAPKKMGYILEGFDRPTHFAGV 127 Helicobacter hepat...
CAD73378   75 IEDDLAMLRDAGVEAv--FMPTADEMYPggpq---------------------thaTSVHPSAVAFPLEGVHRPEHFVGV 131 Pirellula sp. 1
P56061     72 LEKDLALCEKLGVNAv--FVPKIGEMYPyeae---------------------qrlKLYAPKFLSSSLEGAMRKGHFDGV 128 Helicobacter pylori
NP_871451  76 LNEDIKKLIEYKVDIl--FCPTLKSMYPfgy----------------------knhTLVNVVQYSSILDGKTMSNHFIGV 131 Wigglesworthia glo...

Feature 1       ##             ## ##  #                    ###       ####                     
1IHO_A    131 STIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFdIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSS 210 Escherichia coli
1N2B_A    140 LTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQLVADFNLdVAVVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALTA 219 Mycobacterium tube...
NP_893707 132 CTVVYRLLKLIQPKNLFLGEKDWQQLLIIKNLIEEKKFnIKIIPVPTQRDSDGVPFSSRNKHLSKSERKSLKLFSNELEN 211 Prochlorococcus ma...
Q9FKB3    157 ATIVTKLFNIVEPDVALFGKKDYQQWRIIQRMVRDLNFgIEIVGSDIAREKDGLAMSSRNVRLSDEERQRALSISRSLAM 236 thale cress
P57292    131 TTIITKLFNFIQPDFAFFGEKDYQQLLIIKILVKELNYmIKIISLPTIRLKNGLALSSRNNYLSSQENEIAPYLYKIIKK 210 Buchnera aphidicol...
NP_876137 137 ATVVVRLLALVRPNRIFLGEKDWQQLVILRQLINDLGLpVLIHSIPTKRDQDGLPCSSRNVNLSKEERKKVVALPAVLQQ 216 Prochlorococcus ma...
NP_859566 128 LQIVLKLFCLIKPHRAYFGQKDAQQVLILQKMVRDLFLdIHIVPCPIQRDSDGLALSSRNIYLSASERQKALCIPRTIEL 207 Helicobacter hepat...
CAD73378  132 ATVVMKLFQAAPSDRAFFGRKDLQQLCVIEHMVRDLNLpIEIVPCDIVREPDGLAMSSRNRYLSDDQRQRALCISKSLNQ 211 Pirellula sp. 1
P56061    129 VQIVLKMFHLVNPTRAYFGKKDAQQLLIIEHLVKDLLLdIEIAPCEIVRDDDNLALSSRNVYLNATQRKQALAIPKALEK 208 Helicobacter pylori
NP_871451 132 ATIISKLFNLINPDIAIFGQKDFQQLIMIRQLVLHMNYnIKILSAPIIRCFDGLALSSRNRHLSLEERKKAPKIYNILLE 211 Wigglesworthia glo...

Feature 1                                                                                
1IHO_A    211 IADKlqag-----erdLDEIITIAGQELNek-gfRADDIQIRDADtllev-setsKRAVILVAAWLGDARLIDNK 278 Escherichia coli
1N2B_A    220 AAHAat--------agAQAALDAARAVLDaapgvAVDYLELRDIGlgpm---plnGSGRLLVAARLGTTRLLDNI 283 Mycobacterium tuberculosis
NP_893707 212 AKIIfk--------kdKRIDLKQLTNKLKsk-niSIEYLEHLHPYslkkv-qsndNISILAGAIKCGKTRLIDHV 276 Prochlorococcus marinus...
Q9FKB3    237 AKASvaeg-----ktnCAELKDMIIQQVVgs-agRVDYVEIVDQEtlegv-eeikSGVVICVAAWFGTVRLIDNI 304 thale cress
P57292    211 TCEKiike----ddniRPKIIHESKILLIkk-gfSVDIFDIYDYKnlehp-skkvKKVILLASVWLGNTRLIDNK 279 Buchnera aphidicola (Ac...
NP_876137 217 AAQAfq--------enKPINLNNMKTTLEeh-dlKVEYLETVDLKnlnpvnhdesKLCLLAAAVHCGNTRLIDHG 282 Prochlorococcus marinus...
NP_859566 208 VKKRilqg-----ereVATLREIALQSLQse-diTLFYAQFCNHKlepit-hiveNKSIFLIAAKVGQTRLLDNL 275 Helicobacter hepaticus ...
CAD73378  212 VEQAfleg-----nhdPKQLESIMADHLSpc--dSVDYAVVVDRQtllpi-seitQNAVALVAVRVGVTRLIDNR 278 Pirellula sp. 1
P56061    209 IQQAidkg-----ekaCEKLKKLGLEILEt---lEVDYLECCNHKleplt-iiepTNTLILVAARVGKTRLLDNL 274 Helicobacter pylori
NP_871451 212 LSKKiklnklynlkkdYDAILKNYLIKLNny-gfKVEVLSIRNAKnlmpi-densKQAVILCSAKIGSIRLVDNI 284 Wigglesworthia glossini...

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