1DW9,2IU7,2IUO


Conserved Protein Domain Family
Cyanase_C

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cd00559: Cyanase_C 
Click on image for an interactive view with Cn3D
Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the toxicity of environmental cyanate and to use cyanate as a source of nitrogen for growth. This enzyme is a homodecamer, formed by five dimers. Each monomer is composed of two domains, an N-terminal helix-turn-helix and this structurally unique C-terminal domain.
Statistics
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PSSM-Id: 238313
Aligned: 121 rows
Threshold Bit Score: 118.407
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteoligomer
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1DW9_A; cyanase showing bound chloride ions, defined by 3.5 A contact
  • Comment:chloride is a competitive inhibitor of cyanate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                                          ##                          
1DW9_A        87 RIPTDPTXYRFYEXLQvYGTTLKALVHEKF-----------------GDGIISAINFKLDVKKVADPeGGERAVITLDGK 149 Escherichia coli
ZP_01128696   80 TVPRDPLIYRLYEVMTvYGESIKQVIHEKF-----------------GDGIMSAIDFTLDVDVEKDP-KGDRVVLTWNGK 141 Nitrococcus mob...
YP_743416     79 EMLSDPLVYRLNEVVMvYGETLKQVIQEKF-----------------GDGIMSAIDFTMEVDKVEDP-KGDRVVLTLNGK 140 Alkalilimnicola...
XP_570603    109 VPPKDPVLYRLYEVLVvYGYSYKALIYEKF-----------------GDGIMSAIDFRTSLERKKDP-KGDRVVITMDGK 170 Cryptococcus ne...
Q9FWK4        85 DIVHEPAIYRLNEAVMhFGESIKEIINEEF-----------------GDGIMSAIDFYCSVDKVQGAdGKDRVVVTFDGK 147 rice
O22683        82 NLIQEPTIYRLNEAVMhFGESIKEIINEDF-----------------GDGIMSAIDFYCSVDKIKGVdGNNRVVVTLDGK 144 thale cress
EAU85164      83 VPPSDPVIYRLFEGVLvYGHPIKAIIHEKVvslpfiqsrvlkwtrqfGDGIMSMIDCNINVERKPDP-KGDRVVVTFDGK 161 Coprinopsis cin...
ZP_01617403   87 AVPTDPLVYRLYEVVGvYGDTLKEVIQEKF-----------------GDGIMSAIDFSMEVDKIEDP-KGDRVLLTLNGK 148 marine gamma pr...
NP_001064827  85 DIVHEPAIYRLNEAVMhFGESIKEIINEEF-----------------GDGIMSAIDFYCSVDKVQGAdGKDRVVVTFDGK 147 Japanese rice
AAM63250      82 NLIQEPTIYRLNEAVMhFGESIKEIINEDF-----------------GDGIMSAIDFYCSVDKIKGVdGNNRVVVTLDGK 144 thale cress
Feature 1               
1DW9_A       150 YLPTKPF 156 Escherichia coli
ZP_01128696  142 FLPYKRW 148 Nitrococcus mobilis Nb-231
YP_743416    141 FLPYKRW 147 Alkalilimnicola ehrlichei MLHE-1
XP_570603    171 FLPYSDP 177 Cryptococcus neoformans var. neoformans JEC21
Q9FWK4       148 YLPYSEQ 154 rice
O22683       145 YLSHSEQ 151 thale cress
EAU85164     162 FLPYSKW 168 Coprinopsis cinerea okayama7#130
ZP_01617403  149 FLPYKSW 155 marine gamma proteobacterium HTCC2143
NP_001064827 148 YLPYSEQ 154 Japanese rice
AAM63250     145 YLSHSEQ 151 thale cress

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