2UZH,1JY8,1W57,1IV1,2PMP,1JN1,3B6N


Conserved Protein Domain Family
MECDP_synthase

?
cd00554: MECDP_synthase 
Click on image for an interactive view with Cn3D
MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis. This pathway is present in bacteria, plants and some protozoa but is distinct from that used by mammals and Archaea. MECDP_synthase forms a homotrimer, carrying three active sites, each of which is formed in a cleft between pairs of subunits.
Statistics
?
PSSM-Id: 100025
View PSSM: cd00554
Aligned: 114 rows
Threshold Bit Score: 122.168
Threshold Setting Gi: 51701594
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:CDP-binding sites
Evidence:
  • Structure:1UZH; Mycobacterium 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase with bound CDP
    View structure with Cn3D
  • Comment:enzyme forms a homotrimer with three active sites, each formed in the cleft between pairs of subunits

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2UZH_A         7 RVGLGTDVHPIe-------------------------aGRPCRLLCLEFDDa-dGCAGHSDGDVAAHALCDALLSAAGLG 60  Mycobacterium s...
3B6N_A         6 RIGQGYDIHQIrvgppedivadttadtaantadpnkqsFKRLTIGGVPVETi--SVLSHSDGDVIFHALVDALLGGMSCS 83  Plasmodium viva...
Q9Z805        17 RTGIGQDSHRFlpe----------------------ssTKPCILGGIIFDHc-pGFQANSDGDIIFHAICNAISSVTNKI 73  Chlamydophila p...
ZP_01999182    4 KTGLGQDSHRFdfd----------------------nqMKRLMLGGVIFDGe-sPLQGNSDADVVLHALCNAISGITGIN 60  Beggiatoa sp. PS
YP_903954      4 NTGLGQDSHAFcd------------------------tNKPLVLAGVVFDYp-kGLDANSDGDVIFHSITNAISSITGVN 58  Candidatus Ruth...
ZP_01575313   14 KVGIGQDSHRFdfq----------------------nnSKKFILGGVIFDDv-tPLDGNSDADVVLHALTNAISGVTCVN 70  Clostridium cel...
CAK98529       2 RVGNSYDLHNLk-------------------------mGTGFYLGGILIPCq-yQVEAVSDGDILLHTISEAIIGALGLG 55  Spiroplasma citri
NP_758408     17 KIGNGIDIHKIkk------------------------eKCKQRLAGLDFELd-yKIIAHSDGDIILHSISSAILGALSLQ 71  Mycoplasma pene...
Q7NC56         6 RIGQGFDSHKLkt-----------------------kkNSRVFLGGIPVRTd-qQLIANSDGDVVLHALSDAVLGCGSFG 61  Mycoplasma gall...
XP_001609446  39 RIGLGYDIHRLvgt---------------------gkgGKPFKLGGVLVDDskiFVVGHSDGDTLLHALADALLGATGCG 97  Babesia bovis T2Bo
Feature 1        # #                                         ##  ####                        ### 
2UZH_A        61 DLGTIFGTdrpqwrGASGADMIRHVRGLVENagfvIGNATVQVIGNr-PKVGPRREEAQQVLSELVga---pVSVSATTT 136 Mycobacterium s...
3B6N_A        84 DLGTLFPDgspkykNKNSLSFLRYARLLLYKrnyaIANVDIIVIAEv-PKISPIREEIVRNISSALgisesqVSLKGKTH 162 Plasmodium viva...
Q9Z805        74 ILGKVADEllqtrgITDSGIYLEEALKSLKPnq-kISHVAITIEGSr-PKFLCKLSALRQNIAQVMnltptdIGITATSG 151 Chlamydophila p...
ZP_01999182   61 ILGAVSDAlclkhgITDSRFYVQEALNYLKDw--rICHVSFSIECKv-PKITPKIPEMKATISELLgletqdIGITATTG 137 Beggiatoa sp. PS
YP_903954     59 VLGAKADVlck-qgVTDSAEYLRLAFNDLNHc--kIQHIAISIECLy-PKISPMIEKMKFNISKLLnitledVGITATTG 134 Candidatus Ruth...
ZP_01575313   71 ILGKVSDEmclergITDSSEYLREALKYLVDv--kVVHVSISIECSy-PKISPKIAEMRKSISELLgipencVGITATTG 147 Clostridium cel...
CAK98529      56 DLGEWFDEtn---kKINSQLILKKALTLMAEqnyqISNIDTTIIIDe-PRLQKHKKAIKTNLQKLLqisaekINLKATTT 131 Spiroplasma citri
NP_758408     72 DLGTYFSDtdsknkNLDSLEILSMCLNELKKqdysISNVDITIICEy-IIFKDIKDQIKSNLEKLLnn--teISLKATRY 148 Mycoplasma pene...
Q7NC56        62 DIGMYFDEndlsnkGLDSKTILNYCLKLIKKlkleFVNIDLTIFAQd-IRIDPIRFEIKSSLMKLTgc--nsVNVKAKSY 138 Mycoplasma gall...
XP_001609446  98 DIGDYFSEldsinkDMDSRIILESAIKEASLrgyrPTNIDINIILErvRLGRRLKDAIKKALYDMLgsd-vmINVKAKTN 176 Babesia bovis T2Bo
Feature 1                            
2UZH_A       137 DGLgltgrgeGLAAIATALV 156 Mycobacterium smegmatis
3B6N_A       163 EQLgpvgqkkAIECFANALL 182 Plasmodium vivax SaI-1
Q9Z805       152 EGLsdfgcgdGVQCFCVLTV 171 Chlamydophila pneumoniae
ZP_01999182  138 EGLtdfgrgeGIQVLCIVTA 157 Beggiatoa sp. PS
YP_903954    135 EGLtefgkgnGIQVFSIITV 154 Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica)
ZP_01575313  148 EGLtafgqgkGVQAFCIVTA 167 Clostridium cellulolyticum H10
CAK98529     132 EQNfp----nIIQSYTTLLL 147 Spiroplasma citri
NP_758408    149 EEDk-----nMIQVNTVLLI 163 Mycoplasma penetrans HF-2
Q7NC56       139 EEPk-----nEIACSCVVLM 153 Mycoplasma gallisepticum
XP_001609446 177 EGLdaigrgeAVSCQVIAHL 196 Babesia bovis T2Bo

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap