1IMU,1VOZ


Conserved Protein Domain Family
RaiA
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cd00552: RaiA 
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RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).
Links
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Statistics
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PSSM-Id: 238308
Aligned: 142 rows
Threshold Bit Score: 57.1397
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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30S subunit
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:30S subunit binding site
Evidence:
  • Structure:1VOZ_a; PY binds to the 30S subunit in the 70S ribosome.
  • Comment:PY binds across the channel in the 30S subunit where tRNAs and mRNA interact during protein synthesis.
  • Comment:3.5 Angstrom contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # # #                 #   #      ##   #   #              #  ## ##  # #  # #  #
1IMU_A        2 TLNITSKQMDITPAIREHLEERLAK-LGKWq-tQLISPHFVLNKVp------nGFSVEASIGTP-LGNLLASATSDDMYK 72  Haemophilus infl...
1VOZ_a        1 TMNITSKQMEITPAIRQHVADRLAK-LEKWq-tHLINPHIILSKEp------qGFVADATINTP-NGVLVASGKHEDMYT 71  Escherichia coli
ZP_00512050  11 SVQVTLRHSSNHTSIEEYARTAVQS-LARVf-pGIISCHIILDHQknd--vekNKLAEITVHVP-QNVLVAKDAAAAYEP 85  Chlorobium limic...
NP_662517    28 TVKVTLRHSNNHGSIEDYARNAVSG-LSKFy-aGALNCHVILDHQknd--hdqNKLAEITVHVP-QHDFVARESAPTYEQ 102 Chlorobium tepid...
ZP_00530987  11 NVQVTIRHTNNHRDIEQYARDAVQA-LGKIf-sGIVNTHVILDHQknd--yekNKIAELTVHIP-QNTLVAKEGASTYEQ 85  Chlorobium phaeo...
AAQ65592    305 DVRIQALHFDATDQLKDFVQKKISK-LNRLs-dGITGAEVVLKLVkpe--tvqNKEASIRLYIP-GDDLFAEKIADTFEE 379 Porphyromonas gi...
AAO77847      2 DIRIQSIHFDASEQLQAFIQKKVSK-LEKYy-eDIKKVEVSLKVVkpe--aaeNKEAGIKILIP-NGEFYASKVCDTFEE 76  Bacteroides thet...
ZP_00402250  35 KLVIHSHHLTLPPDLGAFLRKHVTRpLARLqddSASELSVHLGDArrkk-ggvDQECRLSFRMPgARTLHVESVQDDLHT 113 Anaeromyxobacter...
ZP_00314627   4 NADVVYRDLDTSPALNDVIYKKMEK-LHRYs-dSIIHSKVVLDSPhnqkhkgkLYRASIEIGLK-GHPLTVSQDAPNVHI 80  Microbulbifer de...
CAG35815      2 ELKVETRNVDLRKSWQEKIDTESEK-LIRHyanFILHLRVAIEANthh--kegGYEVRLVASVP-QDTVVVTRSGEVVRA 77  Desulfotalea psy...

Feature 1                    ##   #
1IMU_A       73 AINEVEEKLERQLNKLQHK 91  Haemophilus influenzae
1VOZ_a       72 AINELINKLERQLNKLQHK 90  Escherichia coli
ZP_00512050  86 AVDACVDSLARQLQKYKEK 104 Chlorobium limicola DSM 245
NP_662517   103 AIENCIDVLERQLKKLKEK 121 Chlorobium tepidum TLS
ZP_00530987  86 AIDSCVDAMGRQLRKHKEK 104 Chlorobium phaeobacteroides BS1
AAQ65592    380 AIDLTVDALKRQIEKRKEQ 398 Porphyromonas gingivalis W83
AAO77847     77 AVDLDVEALEKQLVKYKEK 95  Bacteroides thetaiotaomicron VPI-5482
ZP_00402250 114 ALLDAAERLKRLVKRELEK 132 Anaeromyxobacter dehalogenans 2CP-C
ZP_00314627  81 AVRDAFAAAERKIKEDNSK 99  Microbulbifer degradans 2-40
CAG35815     78 VLTEAFDVLALQLKEIQRK 96  Desulfotalea psychrophila LSv54

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