1E6V,1E6Y,1HBM


Conserved Protein Domain Family
MCR_gamma
?
cd00539: MCR_gamma 
Click on image for an interactive view with Cn3D
Methyl-coenzyme M reductase (MCR) gamma subunit. MCR catalyzes the terminal step of methane formation in the energy metabolism of all methanogenic archaea, in which methyl-coenzyme M and coenzyme B are converted to methane and the heterodisulfide of coenzyme M and coenzyme B (CoM-S-S-CoB). MCR is a dimer of trimers, each of which consists of one alpha, one beta, and one gamma subunit, with two identical active sites containing nickel porphinoid factor 430 (F430).
Links
?
Statistics
?
PSSM-Id: 238301
Aligned: 6 rows
Threshold Bit Score: 427.68
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
cofactormultimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:cofactor binding site
Evidence:
  • Structure:1E6V; Methanopyrus kandleri MCR with bound F430
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1E6V_C      7 FYYPGETDVAENRRKYMNpnyeLKKLREIPDEDIVRLMGHREPGEEYPSVHPPLEEMEEPECPIRELVEPTEGAKAGDRI 86  Methanopyrus kandleri
1E6Y_C      5 QYYPGATSVAANRRKHMSg--kLEKLREISDEDLTAVLGHRAPGSDYPSTHPPLAEMGEPAXSTRENVAATPGAAAGDRV 82  Methanosarcina bar...
1HBM_C      2 QYYPGTTKVAQNRRNFCNpeyeLEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPIDGAKAGDRV 81  Methanothermobacte...
Q58255      6 QFYPGQTKIAQNRRDHMNpdvqLEKLRDIPDDDVVKIMGHRQPGEDYKTVHPPLEEMDLPEDYVRDLVEPLNGAKEGHRI 85  Methanocaldococcus...
NP_276258   6 QYTPGETQIAENRRKHMDpdyeFRKLREVSDEDLVKVLGHRNPGESYKSVHPPLDEMDFEEDIVRDMVEPIQGAKEGVRV 85  Methanothermobacte...
AAU82959    3 QYCQGKTHIADTRRKYMNpdvkLEKLRDIAEEDIVRLLAHRAPGEEYKSIHPPLEEMEEPDCAVRQMVEPTEGAKAGDRI 82  uncultured archaeo...

Feature 1                                       ####                                 #### #   
1E6V_C     87 RYIQFTDSVYFAPIHPYIRARMYMWRYRGVDTGSLSGRQIIEVRERDLEKIAKELLET-EIFDPARSGVRGATVHGHALR 165 Methanopyrus kandleri
1E6Y_C     83 RYIQFADSMYNAPATPYFRSYFAAINFRGVDPGTLSGRQIVEARERDMEQCAKVQMET-EITDHALAGVRGATVHGHSVR 161 Methanosarcina bar...
1HBM_C     82 RYIQFTDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIETRERDLEKISKELLET-EFFDPARSGVRGKSVHGHSLR 160 Methanothermobacte...
Q58255     86 RYIQFTDSMYFAPAQPYDRARTYMWRFRGVDTGTLSGRQVIEMRESDLEALSKNFLIDtAFFDPARIGIRGATVHGHSLR 165 Methanocaldococcus...
NP_276258  86 RYIQFADSMYNAPAQPYDRARTYMWRYRGVDTGTLSGRQVIEMRELDLEGVSKELVET-ELFDPATTGIRGATVHGHSLR 164 Methanothermobacte...
AAU82959   83 RYVQYTDSMFFSPITPYLRAQSAFNRYRGIDPGVLSGRVIIEARERDVEKIAKETLDS-ELFDTARTGLRGRTVHGHAVR 161 uncultured archaeo...

Feature 1                                                                                     
1E6V_C    166 LDENGLMLHALRRYRLNEetGEVEYVKDQVGIELDEPIPVGAPADEDDLKERTTIYRIDG---TPYREDEELLQVVQRIH 242 Methanopyrus kandleri
1E6Y_C    162 LQEDGVMFDMLDRRRLEN--GTIIMDKDQVAIPLDRKVDLGKPMSSEEAAKRTTIYRVDN---VAFRDDAEVVEWVHRIF 236 Methanosarcina bar...
1HBM_C    161 LDEDGMMFDMLRRQIYNKdtGRVEMVKNQIGDELDEPVDLGEPLDEETLMEKTTIYRVDG---EAYRDDVEAVEIMQRIH 237 Methanothermobacte...
Q58255    166 LDENGLMFDALQRYVYDEktGHVLYVKDQVGRPLDEPVDVGEPLPEEKLKEITTIYRIDG---VPMREDEELLTVVKRIH 242 Methanocaldococcus...
NP_276258 165 LDENGLMFDALQRYVFDEekGHVVYVKDQVGRPLDEPVDMGQPLGEDELKKITTIYRKDN---IAMRDDKEAIEVVENIH 241 Methanothermobacte...
AAU82959  162 LDADGMMFDALRRWSVDErtKEVTYVKDMIGGAMDKEVVLGKPLPEADLLKRTCMYRNAQggvWQEEDDPESMDVCAEIH 241 uncultured archaeo...

Feature 1               
1E6V_C    243 ELRTLAGYRP 252 Methanopyrus kandleri
1E6Y_C    237 DQRTKFGFQP 246 Methanosarcina barkeri
1HBM_C    238 VLRSQGGFNL 247 Methanothermobacter thermautotrophicus
Q58255    243 RARTLGGFLP 252 Methanocaldococcus jannaschii
NP_276258 242 TGRTMGGFGM 251 Methanothermobacter thermautotrophicus str. Delta H
AAU82959  242 WKRTVGGFQP 251 uncultured archaeon GZfos24D9

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap