1G8M,1CE8,1EGH


Conserved Protein Domain Family
MGS-like
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cd00532: MGS-like 
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MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate synthetase (CPS) where it catalyzes the last phosphorylation of a coaboxyphosphate intermediate to form the product carbamoyl phosphate and may also play a regulatory role. This family also includes inosine monophosphate cyclohydrolase. The known structures in this family show a common phosphate binding site.
Links
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Statistics
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PSSM-Id: 238297
Aligned: 5 rows
Threshold Bit Score: 104.515
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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substrate
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:1G8M_A binds guanosine-5'-monophosphate
  • Structure:1CE8_A binds inosine monophosphate (IMP)
  • Structure:1EGH_C binds 2-phosphoglycolic acid
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #     #                     # ##                                            
1G8M_A       7 LALLSVs--eKAGLVEFARsln--algLGLIASGGTATALRd-aGLPVRDvsdltgfpexlggrvktlhpavhAGILarn 81   chicken
BAA21088  1308 GVFISCd--vDAMAEDLCPtlsa-sdrFPVFTSKQTSRVLAd-yGIPHTVltqrhed----------septfdTAVAvk- 1372 Trypanosoma cruzi
1CE8_A     944 RALLSVregdKERVVDLAAkll--kqgFELDATHGTAIVLGe-aGINPRLvnkvhe-----------grphiqDRIKn-- 1007 Escherichia coli
1EGH_C      13 HIALVAhdhcKQMLMSWVErhqplleqHVLYATGTTGNLISratGMNVNAmlsgpmg----------gdqqvgALISe-- 80   Escherichia coli
NP_692001  943 GVFLSVsdlwKEDSIAFMNkys--hvfSRLSATEGTSKFLQe-kGFSIEAisk------------------diGMIEeyf 1001 Oceanobacillus i...

Feature 1                          #                                                       
1G8M_A      82 ipednadxnkqdfsLVRVVVCnlypfvktvsspgvtvpeavekidiggVALLRAAaknh--arvtVVCDPADYSSV 155  chicken
BAA21088  1373 -------------eKFDLVIQlrdkrqdfm---------lrrctqenaTADYWIRrlavdynhslLTEPNVVRMFC 1426 Trypanosoma cruzi
1CE8_A    1008 -------------gEYTYIINttsgrr----------------aiedsRVIRRSAlqy----kvhYDTTLNGGFAT 1050 Escherichia coli
1EGH_C      81 -------------gKIDVLIFfwdplna-------------vphdpdvKALLRLAtvw----nipVATNVATADFI 126  Escherichia coli
NP_692001 1002 -----------nehQPDVVINipnqgr---------------dktrlgYLLRELCnry----kipYFTSFETAQTV 1047 Oceanobacillus iheye...

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