1HJR,4LD0,1VHX,1KCF,4EP5,1NU0,6KVN,6LCT,6KVO,6JRF


Conserved Protein Domain Family
RuvC-like
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cd00529: RuvC-like 
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Crossover junction endodeoxyribonuclease RuvC and similar proteins
The RuvC-like family consists of bacterial RuvC, fungal Cruciform cutting endonuclease 1 (CCE1), bacterial YqgF and monokaryotic chloroplast 1 protein (MOC1). RuvC, CCE1 and MOC1 are Holliday junction resolvases (HJRs), endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. RuvC is part of the RuvABC pathway in Escherichia coli and other Gram-negative bacteria that is involved in processing Holliday junctions, which are formed by the reciprocal exchange of strands between two DNA duplexes. CCE1 is a HJR specific for 4-way junctions; it is involved in the maintenance of mitochondrial DNA. Escherichia coli YqgF has been shown to act as a pre-16S rRNA nuclease, presumably as a monomer. It is involved in the processing of pre-16S rRNA during ribosome maturation. HJRs occur in archaea, bacteria, and in the mitochondria of certain fungi. RuvC and its orthologs are homodimers and display structural similarity to RNase H and Hsp70.
Links
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Statistics
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PSSM-Id: 438561
Aligned: 10 rows
Threshold Bit Score: 97.4881
Created: 7-Mar-2002
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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nucleic acidhomodimer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleic acid substrate binding site [nucleic acid binding site]
Evidence:
  • Structure:4LD0: Thermus thermophilus RuvC homodimer in complex with Holliday Junction substrate; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                           #                                             
1HJR_A      3 ILGIDPGsrVTGYGVIRqvgr---qlsYLGSGCIRtkvddl----------psrlklIYAGVTEIItq---fqPDYFAIE 66  Escherichia coli
4LD0_A      6 VAGIDPGitHLGLGVVAvegkgalkarLLHGEVVKtspqepa---------kervgrIHARVLEVLhr---frPEAVAVQ 73  Thermus thermophil...
1VHX_A      5 ILGLDLGtkTLGVALSDexg-----wtAQGIETIKinea--------------egdyGLSRLSELIkd---ytIDKIVLG 62  Bacillus subtilis
1KCF_A     42 VLGIDLGikNFSYCFASqned--skviIHNWSVENltekngldiqwtedfqpssmadLSIQLFNTLhek--fnPHVILME 117 Schizosaccharomyce...
4EP5_A      3 VAGIDPGitHLGLGVVAvegkgalkarLLHGEVVKtspqepa---------kervgrIHARVLEVLhr---frPEAVAVE 70  Thermus thermophil...
1NU0_A      5 LXAFDFGtkSIGVAVGQrit-----gtARPLPAIKaqd----------------gtpDWNIIERLLke---wqPDEIIVG 60  Escherichia coli
6KVN_A      8 VIGVDPDt-SGALALLKpn-------qPPQVFDSPhlkvlvg--------kgvrkrlDAKAIVQLLksfeapiGTTVYVE 71  common tobacco
6LCT_A      8 VIGVAPDt-SGALALLKpn-------qPPQVFDSPhlkvlvg--------kgvrkrlDAKAIVQLLksfeapiGTTVYVA 71  Nicotiana tabacum
6KVO_A      8 VIGVDPDt-SGALALLKpn-------qPPQVFDSPhlkvlvg--------kgvrkrlDAKAIVQLLksfeapiGTTVYVE 71  common tobacco
6JRF_A     14 VIGVDPDi-GGAIAVLSpd-------gSSQVFDNPfvhivvs--------evirkrlDTKSIIQLLrgldappGTTAYIE 77  Zea mays

Feature 1      ###             #                                                              
1HJR_A     67 QVFMaknad----salkLGQARGVAIVAAVnq----------elPVFEYAarqvkqtvvgigsaeksq------------ 120 Escherichia coli
4LD0_A     74 EQFFyrqne----laykVGWALGAVLVAAFea----------gvPVYAYGpmqvkqalaghghaakee------------ 127 Thermus thermophil...
1VHX_A     63 FPKNxngt-----vgprGEASQTFAKVLETty----------nvPVVLWDerlttxaaekxli----------------- 110 Bacillus subtilis
1KCF_A    118 RQRYrsgiatipewtlrVNMLESMLYALHYaekrnsieqkiqypFLLSLSpkstysywasvlntkasfskkksrvqmvke 197 Schizosaccharomyce...
4EP5_A     71 EQFFyrqne----laykVGWALGAVLVAAFea----------gvPVYAYGpmqvkqalaghghaakee------------ 124 Thermus thermophil...
1NU0_A     61 LPLNxdgt-----eqplTARARKFANRIHGrf----------gvEVKLHDerlstvearsglf----------------- 108 Escherichia coli
6KVN_A     72 QSTPypqdgk--qgwwsGGFGYGMWIGILVas----------gfSVIPVPssawksefqltkersnkdysr--------- 130 common tobacco
6LCT_A     72 QSTPypqdgk--qgwwsGGFGYGMWIGILVas----------gfSVIPVPssawksefqltkersnkdysr--------- 130 Nicotiana tabacum
6KVO_A     72 QSTPypqdgk--qgwwsGGFGYGMWIGILVas----------gfSVIPVPssawksefqltkersnkdysr--------- 130 common tobacco
6JRF_A     78 KSSPfptdgk--qgwwsTGFSYGLWIASLVas----------gfSVVPIAsqtwkayfglmrsetpkddsr--------- 136 Zea mays

Feature 1                                             
1HJR_A    121 ------------vqhmvrtllklpanpqaDAADALAIAIT 148 Escherichia coli
4LD0_A    128 -----------valmvrgilglkeaprpsHLADALAIALT 156 Thermus thermophilus HB8
1VHX_A    111 ----------------aadvsrqkrkkviDKXAAVXILQG 134 Bacillus subtilis
1KCF_A    198 lidgqkilfeneealykwnngsrvefkkdDMADSALIASG 237 Schizosaccharomyces pombe
4EP5_A    125 -----------valmvrgilglkeaprpsHLANALAIALT 153 Thermus thermophilus HB8
1NU0_A    109 ----------------eqggyralnkgkvDSASAVIILES 132 Escherichia coli
6KVN_A    131 ---------qvasqlfpslssllkrkkdhGRAEALLIAAY 161 common tobacco
6LCT_A    131 ---------qvasqlfpslssllkrkkahGRAAALLIAAY 161 Nicotiana tabacum
6KVO_A    131 ---------qvasqlfpslssllkrkkdhGRAEALLIAAY 161 common tobacco
6JRF_A    137 ---------qaasilfpdkdqslklkkhhGRAEALLLAAY 167 Zea mays

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