1EKR


Conserved Protein Domain Family
MoaC
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cd00528: MoaC 
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MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.
Links
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Statistics
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PSSM-Id: 238293
Aligned: 53 rows
Threshold Bit Score: 159.221
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activedimer interfacetrimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:active site residues are involved in 3 different active sites within the hexamer
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #               #      # ##              
1EKR_A       15 MVDVSAKAETVREARAEAFVTMrsETLAMIIdgr---hhKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAE 91  Escherichia coli
O66810        3 TVDITTKIETLREAKAYGRIRLkpETVKLIKenk---vpKGNLVEATKLSGIFGAKKTGELLPFCHPIPLDFVALEVKVN 79  Aquifex aeolicus
Q8TXV5       10 MVDVTGKKEEIRIAEASGFLRLteDGVNAVKsgeshpqgKGDPIEVAKVAAILAVKKTPELVPHCHPIKITGVDVDVEVL 89  Methanopyrus kan...
Q9HQ89       20 MVDVGSKPDTARRAVASGDLHLaeSTIDAVRddg---igKGNVLATARVGAIQAVKHTWETIPMCHQIPITNVDTTFDVR 96  Halobacterium sp...
Q9YCA4       15 MVDITAKEPVRREAVASGFISLkrETVKAIRegr---veKGDVISVASVAAVLAVKETPRLIPLTHPIPIEKVEPEVRVR 91  Aeropyrum pernix
ZP_00307082   1 MIDITDKNTVKREAMATGTIKLnkETIKLIRekq---vkKGDVIETAKIAGTIAVKNTSGMIPYCHPVPVMSIDFNFEVE 77  Ferroplasma acid...
Q9UXF7        7 MVDISQKETVLREAEAEGFIKLknDTIKRIIene---ieKGNVITVAKTAGIMAAKKTSELLPLCHLIPLENVDIDIKIE 83  Sulfolobus solfa...
O59475       15 MVEIGYKDVVFRKAVAKGRIKLkpETVKLIKegk---ieKGNVLATAQIAGILAVKRTPELIPLCHPIPITGVDITFDFG 91  Pyrococcus horik...
O26900       17 MVDVGSKPVVRRTATAEGHILLreDTINLIRekk---ieKGNVLATAQIAAIVAVKRTWEIIPLCHPLPLTGVDVEFDLD 93  Methanothermobac...
Q9HKV1        1 MINISEKAISARTATATGRIHLrrSTIQAIRekk---vkKGDVLEVSRVVGTQHAKNTFLQIPYCHNIPIEGVDVDFNVG 77  Thermoplasma aci...

Feature 1                        #  ###  #          #  #                          
1EKR_A       92 pehnrVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDm-------vIGPVRLLAKSGG 150 Escherichia coli
O66810       80 ed--nLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALDDSm-------vIEEVKLLEKSGG 136 Aquifex aeolicus
Q8TXV5       90 ed--gVKMSVRVKSEGKTGVEMDALTGLVVGLVTLWDMVKYAEKDeegqyphtrIENVRVVEKIIK 153 Methanopyrus kandleri
Q9HQ89       97 dd--rVVLEVAVETTGKTGCEMEALEGVTTGLNVVWDMVKAAEKDadgqypgtaIENVGVDTKEKH 160 Halobacterium sp. NRC-1
Q9YCA4       92 dd--gVEVRVRVATTAKTGVEMEALAGVTAALLTVWDMVKSLEKDetgnypdtvITGVKVEVKRKG 155 Aeropyrum pernix
ZP_00307082  78 ds--kIIVTCRVKAIYRTGVEMEAINGVQVALLTIWDMVKYLEKDetgnypdtsIGNVTVVYKRKG 141 Ferroplasma acidarmanus
Q9UXF7       84 ns--gIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMVKKYEKDengkypytmIDDIKVIDKIKE 147 Sulfolobus solfataricus
O59475       92 ed--yIEVTCEVRAYYKTGVEMEALTGVTVALLAIWDMVKAVEKDekgqypytrIENVHVVEKVKT 155 Pyrococcus horikoshii
O26900       94 dd--rITARVTVRCDGKTGVEMEAVTGVSVALLTIWDMVKSVEKDddgqypetaISNIRVIKKEKL 157 Methanothermobacter thermautot...
Q9HKV1       78 ed--yVEVSCTLTTTYKTGIEMEAISCVSGALINIWDMVKYLEKDesgnypetrIDGIHVVEKRKT 141 Thermoplasma acidophilum

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