1G61,1G62


Conserved Protein Domain Family
IF6

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cd00527: IF6 
Click on image for an interactive view with Cn3D
Ribosome anti-association factor IF6 binds the large ribosomal subunit and prevents the two subunits from associating during translation initiation. IF6 comprises a family of translation factors that includes both eukaryotic (eIF6) and archeal (aIF6) members. All members of this family have a conserved pentameric fold referred to as a beta/alpha propeller. The eukaryotic IF6 members have a moderately conserved C-terminal extension which is not required for ribosomal binding, and may have an alternative function.
Statistics
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PSSM-Id: 238292
Aligned: 18 rows
Threshold Bit Score: 250.665
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
"Velcro"
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:"Velcro" closure
Evidence:
  • Comment:closure method employed by other beta-propeller structures in which the last beta-strand from the C-terminus hydrogen bonds with a beta-strand from the N-terminus

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ###                                                                             
1G61_A      4 IIRKYFSGIPt-IGVLALTTEEITLLPIFLdkDDVNEVSEVLE---TKCLQTNIGGSSLVGSLSVANKYGLLLPkiVEDE 79  Methanococcus jann...
P38619      3 LDKLSIFGTDn-IGIYIFTNDKYTIIPKIDdkEVIEKIQGILK---TEIIQTTISKSVLVGILVTGNNDVILLPrtALAD 78  Sulfolobus acidoca...
NP_147705   9 VEKLSLYGNPn-IGVYLTASDSYVLAPDDIgaDDVRTISEVLGvamERVVRLRVLGMRLVGVLTTGNSRGILLPe-GVDR 86  Aeropyrum pernix
NP_614899   3 VVKASVHGDPn-IGAWIAASEEYAVVAPKVpdDIVERVKEALD---VEVVRTTVAGSNLVGALLAVNSNGALFPrhAREH 78  Methanopyrus kandl...
NP_110530   3 VIRKTSVMRSsfIGIYAKAWDDVAFITKMAdeKTVNEFREVLQ---VDIKRISIDGSTLIGTMIAVNSNGIVLP--YGSN 77  Thermoplasma volca...
NP_393534   1 MIRKTSVLRSnfIGIYAKAWDDVAFITMMAdeKTVADFQEVLQ---VDVRRISIDNSSLIGTMMVMNSNGLIVP--YGSE 75  Thermoplasma acido...
NP_618980   1 MIRTVDIYDTsiIGVFATCTEDVVLVPPLTkpEVCALLEEVLD---VRVIETLVNGSIVVGALSRGNSNGFMLP--YGAR 75  Methanosarcina ace...
NP_632831   1 MIRTVDIYDTsiIGVFATCTEDLALVPPLTkpEVCTILEEALD---VRVVETLINGSTVVGALSRGNSNGFLLPy-GSSV 76  Methanosarcina maz...
NP_444242   1 MLRAAFRGSAy-IGVFARATESCVLVRPDLddDFVDSIADELG---VPAVQTTVGGSSTVGSLAAGNSSGLLVS--NRIR 74  Halobacterium sp. ...
CAD25265    9 SYRIDFEGSSe-IGAYMSLTNTYCVIGRSQs-NNVLKFLQENVa--IPIVETTINSIRSVGSQCRGNRHGLLVPhtITDQ 84  Encephalitozoon cu...
Feature 1                                                                                     
1G61_A     80 ELDRIKNFLkennldLNVEIIKSkntALGNLILTNDKGALISPEL--KDFKKDIEDSLNVEVEIGTIAELPTVGSNAVVT 157 Methanococcus jann...
P38619     79 EIKVIKEQAk----dVRVEVVDIrptALGNIILSNTHGALIYQDLseAEINKVKKALQIDTAIKGTIANIITVGSVAVIT 154 Sulfolobus acidoca...
NP_147705  87 EVELVRKALeg--veVGIVPTRSn--ALGNVIVCNDRACLASPGLe-KEALKTVSDTLGVEVVEGSVAGVYTVGSAIVVT 161 Aeropyrum pernix
NP_614899  79 EIRVVRELGv----eVDVLPSKMn--AVGNLVLTNDHGALVHPDLd-DHALEVIESVLGGRVVRGELGGVKTVGSAGVAN 151 Methanopyrus kandl...
NP_110530  78 IDGLDGIDGr----nVLYLKDKIn--AVGNDIIANDHGAIIHKAFs-NKARKEIEDTLGVETIRTSIGNILTVGSASVLT 150 Thermoplasma volca...
NP_393534  76 ITGLGDLDGr----nVLQLKDKIn--AIGNDIIANDHGAIIHKNFs-NRSRKEIEDTLGVETIRTTIGNILTVGSAGILT 148 Thermoplasma acido...
NP_618980  76 AEMQRFTDIp-----VGILPDRLn--AVGNIVFANDSAALVHPDLs-DKALEAIARTLKVDVYRGTIAGIKNVGMAGVVT 147 Methanosarcina ace...
NP_632831  77 EEMQKRTGVp-----AGILPDRLn--AVGNIVLANDSAALVHPELs-DRALEIIARTLKVEVYRGTIAGIKNVGMAGVVT 148 Methanosarcina maz...
NP_444242  75 ERERDRIEAag--vtVGELPGAVn--AAGNVVVANDDGAYVHSGLs-DDAVAAVEETLDVSATRGQLAGVDTVGTAAVAT 149 Halobacterium sp. ...
CAD25265   85 EIMHIRNSLpe---dVVVRRIEErlnALGNVILCNDHIAIIHGDLd-KESEDLIRDVLQVHVYRQNIGQEPLVGTFGALN 160 Encephalitozoon cu...
Feature 1                                                     #####                
1G61_A    158 NKGCLTHPLVEDDELEFLKSLFKVeyiGKGTANKGTTSVGACIIANSKGAVVGGDTTGPELLIIEDALG 226 Methanococcus jannaschii
P38619    155 DKAGLVHIDATEEELKKLSELFKVk-lDSGTVNFGSVFIRSGLVANRNGVLVGSSTTGAEILRIQRAFS 222 Sulfolobus acidocaldarius
NP_147705 162 NRGGLAHPDASEEELKFLSDVFKVp-fEAGTINFGVEFVRTGLVANSYGALVGEDTTGPEIARIQVALG 229 Aeropyrum pernix
NP_614899 152 SKGAVVHPGATEEEMERVSEVLGVd-vEVGTVNRGSPYVGVGIVVNSKGAVVGEDTTGPELARLEDALY 219 Methanopyrus kandleri AV19
NP_110530 151 SKGMLVNPETDDDELEFLKDFFKVs-vKSGTANFGSIYVGASIVANSKGILVGRDTTPIEIDRIDDVLS 218 Thermoplasma volcanium
NP_393534 149 SKGMLVNPETDDDELEFLRDFFKVs-vKSGTANFGSIYVGASIVANSKGVLVGKDTTPIEMDRIDDVLS 216 Thermoplasma acidophilum
NP_618980 148 NKGLLVHPKVTASEREVLEKIFGFp-vNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALG 215 Methanosarcina acetivorans C2A
NP_632831 149 NKGLLVHPKVTVSEREALEEIFGLp-vNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALG 216 Methanosarcina mazei Goe1
NP_444242 150 TDGVLCHPKATDAELERIEETLGVy-aDVGTVNYGAPLVGSGLVAADDGYLVGDDTTGPEIGRIEDTLG 217 Halobacterium sp. NRC-1
CAD25265  161 NQGMLVHPFTSTECQKELSELLEVn-vVAGTINGGSQCVGGGVVANDWMCIAGIKTTNVEMAVIEGVFD 228 Encephalitozoon cuniculi

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