1I4Y,3U9J


Conserved Protein Domain Family
Hemerythrin-like
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cd00522: Hemerythrin-like 
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Hemerythrin family
Hemerythrin (Hr) and related proteins are found in bacteria, archaea and eukaryotes. They are non-heme diiron oxygen transport proteins. In addition to oxygen transport, members are involved in cadmium fixation and host anti-bacterial defense. They have the same "four alpha helix bundle" motif and similar active site structures. Some members, like Hr, form oligomers, the octameric form being most prevalent, while others are monomeric.
Links
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Statistics
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PSSM-Id: 213981
Aligned: 3 rows
Threshold Bit Score: 109.312
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Fe binding site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: Fe binding site [ion binding site], 6 residue positions
Conserved feature residue pattern:H H E H H [ED]Click to see conserved feature residue pattern help
Evidence:
  • Comment:diferric-oxygen binding site differs in one binding residue
  • Structure:1I4Y, Phascolopsis gouldii methemerythrin di-iron center, contacts at 4A
  • Structure:3U9J; human F-box protein FBXL5 Hr-like domain with bound di-iron, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                         #   #                    #      
1I4Y_A        20 SIIDDEHKTLFNGIFHLAIDDN-------------ADNLGELRRCTGKHFLNEQvLMQASqyqf------ydeHKKEHET 80  Phascolopsis go...
3U9J_B         9 DVFTAPHWRXKQLVGLYCDKLSktnfsnnndfralLQSLYATFKEFKXHEQIENeYIIGLlqqrsq--tiynvHSDNKLS 86  human
XP_001622541  48 QNLDDEHRGLFDVVFDVDAKRGd------------AGAVSKAASAFKGHFTTEEaEMKKGvdagkldgahykgHCTAHNK 115 starlet sea ane...

Feature 1                                               #    #     
1I4Y_A        81 FIHALDnw------------------kgDVKWAKSWLVNHIKtIDFKYKG 112 Phascolopsis gouldii
3U9J_B        87 EXLSLFekglknvkneyeqlnyakqlkeRLEAFTRDFLPHXK-EEEEVFQ 135 human
XP_001622541 116 FLELFGsfgnn-------------lgddEINYSMKWLVNHIKsTDFHYKG 152 starlet sea anemone

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