1EK8,1EH1,1DD5,1GE9


Conserved Protein Domain Family
RRF
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cd00520: RRF 
Click on image for an interactive view with Cn3D
Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of protein synthesis. RRF is believed to bind the ribosome at the A-site in a manner that mimics tRNA, but the specific mechanisms remain unclear. RRF is essential for bacterial growth. It is not necessary for cell growth in archaea or eukaryotes, but is found in mitochondria or chloroplasts of some eukaryotic species.
Links
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Statistics
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PSSM-Id: 238288
Aligned: 24 rows
Threshold Bit Score: 160.888
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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hinge region
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:hinge region
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ####                                                    
1EK8_A      5 IRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYY-GTPTPLRQLASVTVEDSRTLKINVFDR-SMSPAVEKAI 82  Escherichia coli
1EH1_A      6 LYAETRSHMQKSLEVLEHNLAGLRTGRANPALLLHLKVEYY-GAHVPLNQIATVTAPDPRTLVVQSWDQ-NALKAIEKAI 83  Thermus thermophilus
1GE9_A      8 IFKEAEKDMKKAVEYYKNEIAGLRTSRASTALVEEIKVEYY-GSKVPIKQLGTISVPEHNQIVIQVWDQ-NAVPAIEKAI 85  Aquifex aeolicus
6831642     5 TLLEAEEKMEKAVVVAKEDFAAIRTGRAHPAMFNKIVAEYY-GAPTPINQLASFSVPEPRMAVVTPFDK-TALRNIEQAI 82  Streptomyces coeli...
3122778     5 ALFDAEEKMEKAVSVAREDLSMIRTGRANPGMFSRLVIDYY-GSATPITQLASINVPEARLVVIKPYDA-IQLHAIETAI 82  Mycobacterium leprae
2500646     6 YLNFFKETADKKFQWLKEELSKIRTGRPNPKLFDNLLVESY-GDRMPMVALAQIAVNPPREIVIKPFDVkNNINAIYSEI 84  Mycoplasma pneumoniae
1350904     6 YIDFFKQAADKKIQWLKEELTKIRTGRPNPKIFDNLLIESY-GQKMPLISLAQVTINPPREIIIKPFDPkSNTNAIYSEI 84  Mycoplasma genitalium
3122779     2 TLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVY-GTTMRLSDIASISVSDTRQLLISPYDA-GNVSAISKGI 79  Chlamydia muridarum
AAF50297   76 NFDGLNSQMQKSVMQMKEDFVKHLSLRSTSGAIDTLRIKVD-GQEHELQELAQISRKNPKTIIVNMIGFpQTIPDVLKAI 154 Drosophila melanog...
3123156   187 VVQETIKEIQRVEGLLVEELTRHFSLKVDIRQYEDVMVKLEnGKDKPLSMIARVTLKSPLMIMINFQDNpSAIKAAKLAI 266 Caenorhabditis ele...

Feature 1                        ####                                                         
1EK8_A     83 MASdLGLNPNSAGsDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLkdkeisEDDDRRSQDDVQK 162 Escherichia coli
1EH1_A     84 RDSdLGLNPSNKGdALYINIPPLTEERRKDLVRAVRQYAEEGRVAIRNIRREALDKLKKLAkelhlsEDETKRAEAEIQK 163 Thermus thermophilus
1GE9_A     86 REE-LNLNPTVQGnVIRVTLPPLTEERRRELVRLLHKITEEARVRVRNVRREAKEMIEELEgi---sEDEKKRALERLQK 161 Aquifex aeolicus
6831642    83 RDSdLGVNPSNDGnIIRVTFPELTEERRREYIKVAKAKGEDAKVSIRSVRRKAKDSIDKMVkdgevgEDEGRRAEKELDD 162 Streptomyces coeli...
3122778    83 RNSdLGVNPSNDGtLIRVAVPQLTEERRRELVKQAKCKGEDAKVSVRNIRRKVMEELHRIRkdgeagEDEVSRAEKDLDK 162 Mycobacterium leprae
2500646    85 QRAnLGVQPVIDGdKIRINFPPMTQESRLESIKQAKKVVEQIHQELRSVRRDTLQMIKKDDhk---dEDFEEFLKEEVEK 161 Mycoplasma pneumoniae
1350904    85 QRAnIGVQPVIDGeKIRVNFPQITQETRLENIKHVKKIIEQIYQELRVVRRDALQMIKKDNh----nEDLENSLKAEIEK 160 Mycoplasma genitalium
3122779    80 LAAnLNLQPIVEGaTVRINVPEPTEEYRREVIKQLKRKSEEAKVSIRNIRRTCNDRLKKDDsl---tEDAVKGLEKKIQE 156 Chlamydia muridarum
AAF50297  155 EKSgMNLNPQQDGtTLFIPIPKVTKEHRENLSKNAKALFVKYRDAIRGVQNEHIRKLKKQPel---gKDDAFAAQAQVTA 231 Drosophila melanog...
3123156   267 QKStLNVTPQQEGaVLYVNVPPMSKERREKMASDAKGRILNEYKKAINEIYSKSDKKSSNEfs--trPDEAKKTREALLN 344 Caenorhabditis ele...

Feature 1                          
1EK8_A    163 LTDAAIKKIEAALADKEAELM 183 Escherichia coli
1EH1_A    164 ITDEFIAKADQLAEKKEQEIL 184 Thermus thermophilus
1GE9_A    162 LTDKYIDEINKLMEAKEKEIM 182 Aquifex aeolicus
6831642   163 TTAKYVAQVDELLKHKEAELL 183 Streptomyces coelicolor
3122778   163 TTHQYVIQIDELVKHKEGELL 183 Mycobacterium leprae
2500646   162 VNKQYIAQLETIQKQKEKELL 182 Mycoplasma pneumoniae
1350904   161 INKNYSNQLEEIQKDKEKELL 181 Mycoplasma genitalium
3122779   157 LTDKFCKQIEELAKQKEAELS 177 Chlamydia muridarum
AAF50297  232 IADRFISEADKLLASKQKELL 252 Drosophila melanogaster
3123156   345 MKHAAEQRGGLLIEERRKQLL 365 Caenorhabditis elegans

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