Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the A (aminacyl), P (peptidyl) or E (exit) sites of the ribosome, but does interact with 23S rRNA, which has a "kink-turn" secondary structure motif. L32 is overexpressed in human prostate cancer and has been identified as a stably expressed housekeeping gene in macrophages of human chronic obstructive pulmonary disease (COPD) patients. In Schizosaccharomyces pombe, L32 has also been suggested to play a role as a transcriptional regulator in the nucleus. Found in archaea and eukaryotes, this protein is known as L32 in eukaryotes and L32e in archaea.
Structure:1JJ2_X; Haloarcula marismortui ribosomal protein L32e binds 23S rRNA (1JJ2_0), defined using 3.5 A contacts
Comment:23S rRNA has a "kink-turn" secondary structure motif (a kink in the phosphodiester backbone that causes the RNA to make a sharp turn). L32e binds 23S rRNA at a kink-turn.
Jiyao W et al.(2023). "The conserved domain database in 2023.",