1GA8,1LL2,1LL0


Conserved Protein Domain Family
Glyco_transf_8

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cd00505: Glyco_transf_8 
Click on image for an interactive view with Cn3D
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis.
Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
Statistics
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PSSM-Id: 132996
View PSSM: cd00505
Aligned: 8 rows
Threshold Bit Score: 213.457
Threshold Setting Gi: 74603159
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingoligomermetal binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site
Evidence:
  • Structure:1GA8_A: Neisseria Lgtc binds Mn and UDP-2-deoxy-2-fluorogalactose, a donor sugar analog
    View structure with Cn3D
  • Structure:1GA8_A: Neisseria Lgtc binds 4'-deoxylactose, a sugar acceptor analog
    View structure with Cn3D
  • Comment:Donor and acceptor binding seems to be cooperative; in some glycosyltransferases the nucleotide-sugar bind first, and in others, the acceptor

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###  ##                                                                    
1GA8_A       1 XDIVFAADd-NYAAYLCVAAKSVEAAHpdteIRFHVLDAg------iSEANRAAVAAnlrgg-ggniRFIDVNPEdfagf 72   Neisseria mening...
XP_414250   67 ISVVIAASd-ERLGGAIAAMNSIYRNTrs-nVVFYIVTLndtvdhlrLWLRNTALKNlry----hilNFDPRVLEgkvqv 140  chicken
AAU12251   139 IHIAIVCAgyNASRDVVTLVKSVLFHRrn-pLHFHIITDs------iARKILADLFHtwmvp-avhvNFYDADELksevs 210  zebrafish
1LL2_A       4 QAFVTLTTndAYAKGALVLGSSLKQHRt--sRRLAVLTTpq-----vSDTMRKALEIvf-------dEVITVDILdsgds 69   rabbit
AAH39145    85 MHLAVVACg-ERLEETMTMLKSAIIFSik-pLQFHIFAEdq-----lHHSFKGRLDNwsflq-tfnyTLYPITFPsenaa 156  human
XP_422579 1230 LNIFSVASghLYERFLRIMMLSVLKHTkt-pLKFWFLKNy------lSPTFKEFIPYmakky-nfqyELVQYKWPrwlhq 1301 chicken
Q6BUZ2      68 YAYVQYATdfDYLNLAIINFIVLRRSStk-iPNLVVLFNr------aLQEDKNRFDGlrdlslrysvTLKPIPIIenvna 140  Debaryomyces han...
1LL0_A      10 QAFVTLTTndAYAKGALVLGSSLKQHRt--sRRLAVLTTpq-----vSDTMRKALEIvf-------dEVITVDILdsgds 75   rabbit
Feature 1                      #               # ###                                           
1GA8_A      73 pln---irhisittYARLKLGEYia-dcDKVLYLDIDVLVRD------------------SLTPLWdtdl---gdnWLGA 127  Neisseria mening...
XP_414250  141 dpqk--adsikpltFARFYLPNLvp-haEKAIYVDDDVIVQD------------------DILELYntpl---kpgHAAA 196  chicken
AAU12251   211 wipn--khysgihgLMKLVLTKTlpsdlEKVIVLDTDITFAT------------------DIAELWvvfhkfkgqqVLGL 270  zebrafish
1LL2_A      70 ahltlmkrpelgvtLTKLHCWSLtq--ySKCVFMDADTLVLA------------------NIDDLFer-------eELSA 122  rabbit
AAH39145   157 ewk----klfkpcaSQRLFLPLIlk-evDSLLYVDTDILFLR------------------PVDDIWsllkkfnstqIAAM 213  human
XP_422579 1302 qte----kqriiwgYKILFLDVLfplavDKILFVDADQIVRT------------------DLKELRdfnl---dgaPYGY 1356 chicken
Q6BUZ2     141 es------ptwsksFTKFHIFNEvk--yDRIVYFDADSMLLHtqwndnssivnnesnvpeNLDELFtip----eiiDIAL 208  Debaryomyces han...
1LL0_A      76 ahltlmkrpelgvtLTKLHCWSLtq--ySKCVFMDADTLVLA------------------NIDDLFer-------eELSA 128  rabbit
Feature 1        #                                                              ###            
1GA8_A     128 SIDlfverqegyk----------------------------------------qkigxadgeyYFNAGVLLINLkkwr-- 165  Neisseria mening...
XP_414250  197 FSDdcdsttnkvavrgagnqynyi-------------------gfldykketirklamkantcSFNPGVFVANLtew--- 254  chicken
AAU12251   271 VENqsdwylgnlwk---------------------------------------nhrpwpalgrGFNTGVILLLLdrlrk- 310  zebrafish
1LL2_A     123 APDpgw-------------------------------------------------------pdCFNSGVFVYQPsvet-- 145  rabbit
AAH39145   214 APEheeprigwynr---------------------------------------farhpyygktGVNSGVMLMNMtrmrrk 254  human
XP_422579 1357 TPFcdsrremdgyrfw----------------------------------ksgywashlagrkYHISALYVVDLkkf--- 1399 chicken
Q6BUZ2     209 PQAywltkhtkasgkikapdgkgyqdeitalineisksvndslvfeklpsllvqsqklnhrnnFFATHVMVVKPsnei-- 286  Debaryomyces han...
1LL0_A     129 APDpgw-------------------------------------------------------pdCFNSGVFVYQPsvet-- 151  rabbit
Feature 1                                                 ##                             ##    
1GA8_A     166 ------------rhdIFKXSSEWveqykd---------vxqyqDQDILNGLFKgg--------vCYANSRFNFXPTNyaf 216  Neisseria mening...
XP_414250  255 ------------klqNITKQLEKwmtlnvaeelysrtlagsitTPPLLIVFYKq---------hSSIDPLWNVRHLGsna 313  chicken
AAU12251   311 ----------lkweqMWRLTAERelmsml---------stslaDQDIFNAVIKqnp-----flvHQLPCYWNVQLSDhtr 366  zebrafish
1LL2_A     146 ------------ynqLLHVASEQgsf--------------dggDQGLLNTFFNswat---tdirKHLPFIYNLSSISiys 196  rabbit
AAH39145   255 yfkndmttvrlqwgdILMPLLKKykln------------itwgDQDLLNIVFFhnp-----eslFVFPCQWNYRPDHciy 317  human
XP_422579 1400 ------------rkiAAGDRLRGqyqglsqd-----pnslsnlDQDLPNNMIHqv-------piKSLPQEWLWCETWcdd 1455 chicken
Q6BUZ2     287 ------------fneLKKYVHNPwlwslhkrh---alrnksdyDMEVLNKFIDnvlqenenfkvGILPHKVYGVLTGefr 351  Debaryomyces han...
1LL0_A     152 ------------ynqLLHVASEQgsf--------------dggDQGLLNTFFNswat---tdirKHLPFIYNLSSISiys 202  rabbit
Feature 1                                           # ##    #    
1GA8_A     217 xanwfasrht----------dplyrdrtntvxpVAVSHYCGp--AKPWHR 254  Neisseria meningitidis
XP_414250  314 gkry----------------------spqfvkaAKLLHWNGh--FKPWGR 339  chicken
AAU12251   367 sekc-----------------------ykdvsdLKVIHWNSp--KKLRVK 391  zebrafish
1LL2_A     197 ylpa----------------------fkafganAKVVHFLGq--TKPWNY 222  rabbit
AAH39145   318 gsnc----------------------qeaeeggIFILHGNRg--VYHDDK 343  human
XP_422579 1456 s----------------------------skkrAKTIDLCNnpmTKEPKL 1477 chicken
Q6BUZ2     352 ellhesfvseaqflpfitgelneqwrpieiirnIKLIHFSDspiPKPWEG 401  Debaryomyces hansenii
1LL0_A     203 ylpa----------------------fkafganAKVVHFLGq--TKPWNY 228  rabbit

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