1EKG,1EW4


Conserved Protein Domain Family
Frataxin
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cd00503: Frataxin 
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Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.
Links
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Statistics
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PSSM-Id: 238280
Aligned: 21 rows
Threshold Bit Score: 120.063
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative iron
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative iron binding site [ion binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #       ##  #   #  ##         # #                                             
1EKG_A      7 LDETTYERLAEETLDSLAEFFEDLadkpytfeDYDVSFGSGVLTVKLggdLGTYVINKQTPNKQIWLSSPssGPKRYDWt 86  human
AAF46449   68 LDGATYERVCSDTLDALCDYFEELtenaselqGTDVAYSDGVLTVNLggqHGTYVINRQTPNKQIWLSSPtsGPKRYDFv 147 fruit fly
AAC71159   20 FSQNEYETAADSTLERLSDYFDQIadsfpvseQFDVSHAMGVLTVNVsksVGTYVINKQSPNKQIWLSSPmsGPKRYDLe 99  Caenorhabditis ele...
EAA06839   68 IDSVTFVAVCSDTLESLVDYFEQIidetstlkNPDVTYGDGVLTVSFgepHGTYVINRQLPNRQIWLSSPtsGPKRYDFi 147 Anopheles gambiae ...
6016047    42 LTDLEYHRVADDTLDVLNDTFEDLleev-gkkDYDIQYANGVITLMLg-eKGTYVINKQPPAHQIWLSSPvsGPKHYEYs 119 fission yeast
NP_192233  32 NREEEFHKLANFTINHLLEKIEDYgdnv-qidGFDIDYGNEVLTLKLg-sLGTYVLNKQTPNRQIWMSSPvsGPSRFDWd 109 thale cress
Q9ZDK5      1 MNNTAFSKLAETTIVYIVDKIEEQdl----egIIDVDLQGDILNLDTe--NGIYVINTQSASKEIWLSSPvsGPHHFFYe 74  Rickettsia prowazekii
NP_253962   4 MNEARFHDLVDALQQQVEDAFDDSd------lDLDLENAGGVLTVRFe-nGSQLILSRQAPLRQLWVAAKs-GGFHFDYd 75  Pseudomonas aerugi...
NP_283290   2 MTESEFIRASEALFEHIEDQIDENg------wDFDCRFAGNVLTIEAg-dGTQIIVNRHTPNQELWIAAKs-GGYHFAEq 73  Neisseria meningit...
NP_521098   4 LTESEFLALADAELGRIERTVERAade--vdaDIEIGRVGNVLTLEFd-dGSKIIINSQTPMQELWVAARa-GGFHFRRn 79  Ralstonia solanace...

Feature 1                                            
1EKG_A     87 -------gKNWVYShDGVSLHELLAAELTKAl-KTKLDL 117 human
AAF46449  148 gt---vaaGRWIYKhSGQSLHELLQQEIPGIlkSQSVDF 183 fruit fly
AAC71159  100 e------eGKWTYAhDGEQLDSLLNREFRKIlaDDRIDF 132 Caenorhabditis elegans
EAA06839  148 pdkrtvneGYWLYRhDGVTLHELLQREISAIv-GRELEF 185 Anopheles gambiae str. PEST
6016047   120 l-----ksKTWCSTrDEGTLLGILSSEFSKWf-SRPIEF 152 fission yeast
NP_192233 110 r-----daNAWIYRrTEAKLHKLLEEELENLc-GEPIQL 142 thale cress
Q9ZDK5     75 -------qGKWKSR-IGFELMVLLTEELGIR--FDKYEI 103 Rickettsia prowazekii
NP_253962  76 e-----asGLWRHDgSQEPLGALLNRATLEQg-GEDVEF 108 Pseudomonas aeruginosa
NP_283290  74 -------nGKWLATrDSRDFYDVLNEALSAAs-GEAVKI 104 Neisseria meningitidis Z2491
NP_521098  80 -------dGRWVDTrSGEELYVALSRYVSQQs-EVDVTL 110 Ralstonia solanacearum

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