1QFE


Conserved Protein Domain Family
DHQase_I
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cd00502: DHQase_I 
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Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase)
Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase). Catalyzes the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate to produce dehydroshikimate. Dehydroquinase is the third enzyme in the shikimate pathway, which is involved in the biosynthesis of aromatic amino acids. Type I DHQase exists as a homodimer. Type II 3-dehydroquinase also catalyzes the same overall reaction, but is unrelated in terms of sequence and structure, and utilizes a completely different reaction mechanism.
Links
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Statistics
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PSSM-Id: 188633
Aligned: 64 rows
Threshold Bit Score: 83.5431
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1QFE_A: binds 3-amino-4,5-dihydroxy-cyclohex-1-enecarboxylate group
  • Comment:defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                                          # #                              
1QFE_A      17 KIIVSLmgrdi------nsvkAEALAYREat------------fDILEWRVDhfmdias----------tqsvltAARVI 68   Salmonella typhi
Q12659    1061 SYFLSLafs----------dlENIFSLLDiit---------agcDAIEIRIDlfqkpeeidk----ypsleyiaeKIFLL 1117 Pneumocystis car...
P07547    1052 SFFASLtlp----------dlREAGDILEevc---------vgsDAVELRVDllkdpasnnd----ipsvdyvveQLSFL 1108 Emericella nidulans
Q9P7R0    1054 STFLTLnyp----------riEDALPTLRdvt---------vgcDAIEVRVDylkdpkssng----issldfvaeQISLL 1110 fission yeast
CAD21207  1047 SFFVSLtvp----------nvSKALDIIPkvv---------vgsDAVELRVDlledyd-----------pefvakQVALL 1096 Neurospora crassa
NP_622834   53 DACLRFlnedpwerlrelkkrIKNTPLQMllrgqnlvgyrhypdDIVEKFIEkavangidi------irifdalnDVRNL 126  Thermoanaerobact...
AAN70992  1092 SFFLSLtyp----------dlLPAVPSIPllt---------agaDAIELRVDllnpsgdpvtgppnipsldfvatQLSAL 1152 black scurf of p...
CAD71027   178 TYFISTtfp----------dvHAALPNIDilt---------vgaDAVEIRVDllkepladgty-apvpslsyvgeQVMLL 237  Neurospora crassa
XP_401222 1161 TYFLSLtfpd-------vvpkLELIRSMEsg------------sDALEFRADllnpsgqpvtt-pqippteyvknQLAAL 1220 Ustilago maydis 521
EAL22495  1089 TSFLSLtfp----------dvTPALIHLDelt---------egaDAVEFRVDllsttgqaptr-palppisfvakQLASL 1148 Cryptococcus neo...

Feature 1                            #                                                         
1QFE_A      69 RDAmp---------diPLLFTFRSakeggeq-tittqhYLTLNRAAIDsg--------lvDMIDLELftgdadVKATVdy 130  Salmonella typhi
Q12659    1118 RQKts----------lPLIYTLRTtnhggsflssekklAKEYILHGAKwg---------fEFLDIELdia-seLFKTInn 1177 Pneumocystis car...
P07547    1109 RSRvt----------lPIIFTIRTqsqggrfpdnahdaALELYRLAFRsg---------cEFVDLDIa----fPEDMLra 1165 Emericella nidulans
Q9P7R0    1111 RCStt----------lPIIFTIRTisqgglfpndkeeeAKELMLSAMRyg---------cDFVDVELg----wSSETIni 1167 fission yeast
CAD21207  1097 RSAar----------iPIVYTVRTvsqggkfpdddyelALKLYRTGLQag---------vEYLDLEMt----mPDEVIea 1153 Neurospora crassa
NP_622834  127 EVSikatkrvgahaqgTLVYTISPvhtid----hyirvAKELVELGVDsicikdmsgilsPYVAYELvk---rLKETVn- 198  Thermoanaerobact...
AAN70992  1153 RHTss----------lPVVFTVRTasqggafpdtaekeAFALYNLALRhg---------vEYIDVEIs----wSDKKIqd 1209 black scurf of p...
CAD71027   238 RQRte----------lPIIFTTRCtaengrfpmdnpdlYYEYLYRAIQwg---------vEYIDVEIw-----LPERIrr 293  Neurospora crassa
XP_401222 1221 RHRts----------lPIVFTVRThsqggmfpdgkqheYFELISLALRha---------cEYIDLELgwdddlLSAVVqa 1281 Ustilago maydis 521
EAL22495  1149 RLAtt----------lPIVFSVRSkdqggmvpsdnaeaYGALVRLGLRca---------cEYVDLEVc----wPEQLLds 1205 Cryptococcus neo...

Feature 1                     #                                          #                     
1QFE_A     131 ah---ahnVYVVMSNHDFhqtp----------saeEMVSRLRKMQal------gaDIPKIAVMPqskhDVLTLLTATLEM 191  Salmonella typhi
Q12659    1178 s----wpyTKIIASYHNIekpis--------cddfEWIQKYKEAQhy-------gHIIKLVGTSssieDNFFLEEFKSKF 1238 Pneumocystis car...
P07547    1166 vte-mkgfSKIIASHHDPkgels--------wanmSWIKFYNKALey-------gDIIKLVGVArnidDNTALRKFKNWA 1229 Emericella nidulans
Q9P7R0    1168 lyq-hkgyTKLIMSWHDLsgtws-------warphEWMQKVELASsy-------aDVIKLVGMAnnlnDNLELEEFRTRI 1232 fission yeast
CAD21207  1154 vtn-ekgyTHIIASHHDPkatls--------wkngGWIQYYNKALqh-------gDVVKLVGVArelaDNFALARFKASL 1217 Neurospora crassa
NP_622834  199 --------VPIQLHGHYTsgmasmtylkaieagvdAIDTAISPLAlgtsqpatetMVAALKGTQy--dTGLDLELLSEIA 268  Thermoanaerobact...
AAN70992  1210 laa-rkgaSQIIASWHDWsgnmk--------wngaVVKEKYALAErv-------gDIVKIVGKAlsieDNFALRAFAAAH 1273 black scurf of p...
CAD71027   294 rlyeqrgsSRIMSAFHDFsgtfk--------wpsaRAEATFRESArf-------aDIVKMIAIIndhnENFELEYFRSKI 358  Neurospora crassa
XP_401222 1282 k-----gnSQIIASWHDWsgrld--------weseSTAKIYEKACrf-------gDIAKIIGKAttmeDNYSLERFRAKV 1341 Ustilago maydis 521
EAL22495  1206 ivq-lkreTHIIASWHDWtgdma--------wdgeEMKAKHVLCEky-------gDVAKIVGTAksglDNAKLAIFVGEV 1269 Cryptococcus neo...

Feature 1                                 #                   ##  #            
1QFE_A     192 Qqhya------drpVITMSMAkegviSRLAGEv-FGSAATFGAVkqaSAPGQIAvNDLRSVLMI 248  Salmonella typhi
Q12659    1239 Inkk--------vpSIIINTGikgqlSRIMNT--FMTPVTHPSLpskIAPGQLSiKEINTALHI 1292 Pneumocystis carinii
P07547    1230 Aeah-------dvpLIAINMGdqgqlSRILNG--FMTPVSHPSLpfkAAPGQLSaTEIRKGLSL 1284 Emericella nidulans
Q9P7R0    1233 Tnsm-------dipLILFNMGrfgqlSRILNK--FMTPVTHPLLpskAAPGQLTvKQLNEARVL 1287 fission yeast
CAD21207  1218 Aaah-------dkpLIALNMGaagklSRVLNG--FLTPVSHPALpskAAPGQLSaAEIRQALAL 1272 Neurospora crassa
NP_622834  269 SyfkevkrnhyketDFSMVMGi---dTDVLVYqvPGGMLSNLIA---QLKEQKAlDKYKEVLEE 326  Thermoanaerobacter tengcongensis
AAN70992  1274 Tsk----------pFIGINMGaegqlSRVLNT--AFTPVSHPLLptrAAPGQMSvQDIHTALHL 1325 black scurf of potato
CAD71027   359 Kaeyp-----dappLSAVNMGetgqfSRTLNR--VFTPITHPLLpiiAAPGQLSaSEINQALSL 415  Neurospora crassa
XP_401222 1342 Sata-------tkpLLAVNMGsvgqlSRIVNP--VFTPITHEAMpfkAAPGQLSfRQVQTALSL 1396 Ustilago maydis 521
EAL22495  1270 Qshpg------akpLLAINMGaagqlSRILNP--ILTPVTHDALpsrAAPGQLTaREILQARAL 1325 Cryptococcus neoformans var. neo...

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