1OBG,2H31,1KUT,2GQS


Conserved Protein Domain Family
SAICAR_synt
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cd00476: SAICAR_synt 
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5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Links
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Statistics
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PSSM-Id: 133468
Aligned: 5 rows
Threshold Bit Score: 268.178
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2GQS: Escherichia coli SAICAR synthetase complexed with CAIR-Mg2+ and ATP, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #### #         #           #                                        #       
1OBG_A        13 LVARGKVRDIYEVDa--gTLLFVATDRISAYDVIMENs---iPEKGILLTKLSEFWFKFLSn-----dVRNHLVdiapgk 82  baker's yeast
2H31_A        12 KLYEGKTKEVYELLdspgKVLLQSKDQITAGNAARKNh---lEGKAAISNKITSCIFQLLQea----gIKTAFTrkc--- 81  human
1KUT_A         1 XNYEGKTKIVKVTGd---YALLEFKDDITAGDGLKHDv---lTGKGSICAETTAILXKYLSek----gIKTHLVeyi--- 67  Thermotoga mari...
YP_001535501   5 TLPTGRPDITGRSKk---VWFVEPGRCVVEMIPSLRSfthdrDELMDGTAELRLDFFEYVSgvlakagVPTVFRerl--- 78  Salinispora are...
2GQS_A         6 ELYRGKAKTVYSTEnp-dLLVLEFRNDTSAGDGARIEq---fDRKGMVNNKFNYFIMSKLAea----gIPTQMErll--- 74  Escherichia coli

Feature 1                                 #### #   # # #   ###                                 # 
1OBG_A        83 tifdylpaklsepkyktqledRSLLVHKHKLIPLEVIVRGYITGSAWKeyvktgtvhglkqpqgLKESQEFpEPIFTPST 162 baker's yeast
2H31_A        82 -------------------geTAFIAPQCEXIPIEWVCRRIATGSFLKrn------------pgVKEGYKFyPPKVELFF 130 human
1KUT_A        68 -------------------ppRTLKVIPLKXFPLEVVVRLKKAGSFVRry-------------gGAEGEDLpVPLVEFFI 115 Thermotoga mari...
YP_001535501  79 -------------------gpITYLADYRPAVPFEVIVKNRATGSTTRkyp-----------glFEEGRVFaPPVVKFDY 128 Salinispora are...
2GQS_A        75 -------------------sdTECLVKKLDMVPVECVVRNRAAGSLVKrl-------------gIEEGIELnPPLFDLFL 122 Escherichia coli

Feature 1        #      #                                                   ### #             #  
1OBG_A       163 KAEqgeHDENISpAQAAElv--------gEDLSRRVAELAVKLYSKCKDYAKEkgIIIADTKFEFGIDektnEIILVDEV 234 baker's yeast
2H31_A       131 KDDa-nNDPQWSeEQLIAakfcfaglligQTEVDIXSHATQAIFEILEKSWLPqnCTLVDXKIEFGVDvttkEIVLADVI 209 human
1KUT_A       116 KDDe-rHDPXVCvDHLEIlgi------atKKQAEKXKEAAVKITLALKEFFERanFELWDIKYEFGLDkd-gNVVLGDEI 187 Thermotoga mari...
YP_001535501 129 RTDp-eDQPIGE-DYLRRt----------GVDVEAYRRLALACNTVLHTLVSP--LELWDFCLVIAPDee-rGLVINSEI 193 Salinispora are...
2GQS_A       123 KNDa-mHDPMVNeSYCETfgw------vsKENLARMKELTYKANDVLKKLFDDagLILVDFKLEFGLYk--gEVVLGDEF 193 Escherichia coli

Feature 1           ####                                                          
1OBG_A       235 ltPDSSRFWNgasykvgesqdsydkqflrdwltanklngvngvkmpqdivdrTRAKYIEAYETLT 299 baker's yeast
2H31_A       210 d-NDSWRLWPsgdrsqqkdkqsy----------------rdlkevtpeglqxVKKNFEWVAERVE 257 human
1KUT_A       188 s-PDTFRLRKkgeifdkd--------------------------vyrrdlgdPLKKYREVLELCR 225 Thermotoga maritima
YP_001535501 194 s-PDCMRLRRadgepydkdl-----------------------frrgasreqIIERWTELMGLVR 234 Salinispora arenicola CNS-205
2GQS_A       194 s-PDGSRLWDketlekmdk------------------------drfrqslggLIEAYEAVARRLG 233 Escherichia coli

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