2XZM,1D1R


Conserved Protein Domain Family
eIF1_SUI1_like
?
cd00474: eIF1_SUI1_like 
Click on image for an interactive view with Cn3D
Eukaryotic initiation factor 1 and related proteins
Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.
Links
?
Statistics
?
PSSM-Id: 211317
Aligned: 6 rows
Threshold Bit Score: 79.3921
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative rRNA
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative rRNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2xzm: Tetrahymena thermophila eIF1 binds 18S rRNA in the 40S ribosomal subunit, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                #   ## #                 #  ### ### #                    #  #           
2XZM_F        18 HIHIRVEQRRg-RKCFTTVEGIPpe-fDYEKIMKYWKKWLSCNATIVEede-------gkKVIKLNGDHRNQIQQFLSEE 88  Tetrahymena the...
1D1R_A        32 VVRIQRQTSGrkGKGVCLITGVDlddaELTKLAAELKKKCGCGGAVKD------------GVIEIQGDKRDLLKSLLEAK 99  Escherichia coli
EGP90454     541 KIHITLETRSg-NKTVTKVSGLEayhiNARPLADELRKTCAGSTSVEPlagaskknerevMEVMVQGPQKDTVLKALERR 619 Mycosphaerella ...
NP_586471     43 VIRVKVQQKKg-TKKVTIIENIPm--eLRESLLSSLKREMGCGGILLDd----------kSSIQLQGDKTNMGIVTYLKK 109 Encephalitozoon...
XP_002787437  22 APPIKIEKRNk-GKKVTVITNVNg---DNRKLVTHLKTILGVGGTTQGn-----------TTVEIQGDHIDQVVVELKRL 86  Perkinsus marin...
AAC02985     159 KVTIAKIPRAk-KKYVTRVCGLAtfeiDLKEAQRFFAQKFSCGASVTGe-----------DEIIIQGDFTDDIIDVIQEK 226 human

Feature 1                    
2XZM_F        89 Giaa-vdnITIH 99  Tetrahymena thermophila
1D1R_A       100 Gm-----kVKLA 106 Escherichia coli
EGP90454     620 Gvdk--rwVEVL 629 Mycosphaerella graminicola IPO323
NP_586471    110 Yikd--crVELN 119 Encephalitozoon cuniculi GB-M1
XP_002787437  87 Hai---kgMKTT 95  Perkinsus marinus ATCC 50983
AAC02985     227 WpevdddsIEDL 238 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap