1S72,1S1I


Conserved Protein Domain Family
Ribosomal_L24e_L24

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cd00472: Ribosomal_L24e_L24 
Click on image for an interactive view with Cn3D
Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor binding site. L24e/L24 appears to play a role in the kinetics of peptide synthesis, and may be involved in interactions between the large and small subunits, either directly or through other factors. In mouse, a deletion mutation in L24 has been identified as the cause for the belly spot and tail (Bst) mutation that results in disrupted pigmentation, somitogenesis and retinal cell fate determination. L24 may be an important protein in eukaryotic reproduction: in shrimp, L24 expression is elevated in the ovary, suggesting a role in oogenesis, and in Arabidopsis, L24 has been proposed to have a specific function in gynoecium development. No protein with sequence or structural homology to L24e/L24 has been identified in bacteria, but a functionally equivalent protein may exist. Bacterial L19 forms an interprotein beta sheet with L14 that is similar to the L24e/L14 interprotein beta sheet observed in the archaeal L24e structures. Some eukaryotic L24 proteins were initially identified as L30, and this alignment model contains several sequences called L30.
Statistics
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PSSM-Id: 100103
View PSSM: cd00472
Aligned: 72 rows
Threshold Bit Score: 61.4342
Threshold Setting Gi: 33772491
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:23S rRNA interface [nucleic acid binding site]
Evidence:
  • Structure:1S72_U; Haloarcula marismortui ribosomal protein L24e binds 23S rRNA (1S72_0), defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        ##                   ## ##   # #     ##   
1S72_U         1 PRTRECDYCGTDIEPGTGTMFVHK----DGATTHFCSSKCENNADLGREARNLEWTDT 54  Haloarcula marismortui
XP_665614      8 IKTDLCSYSEYRIYPGRGRKFVAR----DGRVSTFLNQKCASLFHQKIRPVKLKWSVG 61  Cryptosporidium hominis TU502
CAD52226       8 VKTEACSFSEYRIYPGRGQKYIAR----DGKVYFYLSSKFASLALQKKKAAKLRWTQT 61  Plasmodium falciparum 3D7
XP_954767      8 IKTEHCNFTDYRVYPGRGKKFVAR----DGKVYFFINGKSAAFHKRKVKPAKLKWNLA 61  Theileria annulata strain Ankara
CAH04415       3 TKTELCHFSEYKVYPGRGHRFVRK----DGRTFFFLSRKTRSLHFQKVKTSDLTWTPM 56  Euplotes vannus
XP_001437444   3 IKTDLCSFSEWRIYPGHGRRFVAK----DGRLFYYLNQKSRAFSARKIKSQEIQWTVA 56  Paramecium tetraurelia
EAR97127       3 VRTGTCSFCEYRIYPGRGQRFIAK----DGRGFFFLTKKAKCLSLRKVKAQKITWTIA 56  Tetrahymena thermophila SB210
AAC63142       1 MRTIDCEFSHFAVHPGHGRRYVPFaflsTKPVLTFARPKCFAMYMRKKNPRFIAWTRT 58  Trypanosoma brucei
XP_001298469   3 TKTEICGFSGHIFHAGHGRVHIRE----DKHLMAFESRKAFRMWERKRNPRKIAWTEH 56  Trichomonas vaginalis G3
NP_586021     14 MIQGVSMFSGRNIPKGSGIYEVMS----DGRAVLTASNKERRLIARKINPRDIRWTTS 67  Encephalitozoon cuniculi GB-M1

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