1FQO,1PBT,1LK7


Conserved Protein Domain Family
SugarP_isomerase
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cd00458: SugarP_isomerase 
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SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.
Links
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Statistics
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PSSM-Id: 238258
Aligned: 3 rows
Threshold Bit Score: 101.661
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1FQO_A; E.coli GlcN6P-deaminase binds fructose-6-phosphate; defined at 3.5A contacts.
  • Citation:PMID 8747459
  • Structure:1LK7_A; Pyrocoocus horikoshii RPI binds Phospho-Erythronic Acid inhibitor; defined at 3.5A contacts.
  • Structure:1PBT_A; Thermotoga maritima 6-Phosphogluconolactonase (Tm1154) binds sulfate ions; defined at 3.5A contacts.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 # ##                          #                     
1FQO_A     13 GKWAARHIvnrinafkptadrpFVLGLPTGGTPMTTYKALVEMhkagqvsfkHVVTFNMdeyvglpkehpesyysfMHRN 92  Escherichia coli
1PBT_A     36 VDFVVEKIrtkxekl-leekdkIFVVLAGGRTPLPVYEKLAEQkfp----wnRIHFFLSderyvpld-sdqsnfrnINEV 109 Thermotoga maritima
1LK7_A     11 AKEALKFIed-----------dMVIGLGTGSTTAYFIKLLGEKlkrg--eisDIVGVPTsy--------------qAKLL 63  Pyrococcus horikoshii

Feature 1                                                 ##                                  
1FQO_A     93 FFDHvdipaeninllngnapdidaecrqyeekirsygKIHLFMGGVGndghiafnepasslasrtriktlthdtrvansr 172 Escherichia coli
1PBT_A    110 LFSRakipsgnvhyvdtslpiekacekyereirsatdQFDLAILGXGpdghvasifdletgnkdnlvt------------ 177 Thermotoga maritima
1LK7_A     64 AIEHdipias----------------------ldqvdAIDVAVDGADevdpnlnlikgr--------------------- 100 Pyrococcus horikoshii

Feature 1                                                                                     
1FQO_A    173 ffdndvnqvpkyaltvgvgtlLDAEEVMILVLgsqkalalqa-------------------------------------- 214 Escherichia coli
1PBT_A    178 -ftdpsgdpkvprvtltfralNTSLYVLFLIRgkekinrlt--------------------------------------- 217 Thermotoga maritima
1LK7_A    101 ----------gaaltmekiieYRAGTFIVLVDerklvdylcqkmpvpievipqawkaiieelsifnakaelrmgvnkdgp 170 Pyrococcus horikoshii

Feature 1                                                         
1FQO_A    215 ---------------------------avegcvnhmwTISClqlhpkAIMVC 239 Escherichia coli
1PBT_A    218 -----------------------------eilkdtplPAYFvrgkekTVWFV 240 Thermotoga maritima
1LK7_A    171 vitdngnfiidakfpriddpldmeielntipgviengIFADi----aDIVIV 218 Pyrococcus horikoshii

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