1FUX,1B7A,1BEH,1FJJ,1KN3,1QOU,1WKP,1WPX,2EVV,2IQX,2R77


Conserved Protein Domain Family
PEBP

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cd00457: PEBP 
Click on image for an interactive view with Cn3D
PhosphatidylEthanolamine-Binding Protein (PEBP) domain
PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).
Statistics
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PSSM-Id: 176642
View PSSM: cd00457
Aligned: 22 rows
Threshold Bit Score: 90.148
Threshold Setting Gi: 71041832
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1FUX_A      4 QVTSn--------EIKt-GEQlttshvfs-----gfgceggNTSP-SLTWSGvpe--------------gtKSFAVTVYD 54  Escherichia coli
1B7A_A     23 PLQVkyg----gaEVDelGKVltp--------------tqvKNRPtSITWDGld---------------pgKLYTLVLTD 69  Bos taurus
1BEH_A     24 PLHVtya----gaAVDelGKVltp--------------tqvKNRPtSISWDGld---------------sgKLYTLVLTD 70  human
1FJJ_A      3 KLISn--------DLRd-GDKlphrhvfn-----gxgydgdNISP-HLAWDDvpa--------------gtKSFVVTCYD 53  Escherichia coli
1KN3_A     20 LLRVtyt----eaEVEelGQVltp--------------tqvKHRPgSISWDGld---------------pgKLYTLILTD 66  house mouse
1QOU_A     28 KMSViynsnnsikHVYn-GHElfp--------------savTSTP-RVEVHGgd---------------mrSFFTLIMTD 76  snapdragon
1WKP_A     30 TLKVtyg----qrEVTn-GLNlrp--------------sqvQNKP-RVEIGGed---------------lrNFYTLVMVD 74  thale cress
1WPX_B     35 ILAVeys---ssaPVAm-GNTlpt--------------ekaRSKP-QFQFTFnkqmqksvpqanayvpqddDLFTLVMTD 95  baker's yeast
2EVV_A     27 EVXIq--------TDS--KGYldakfggnapkaflnsnglpTYSP-KISWQKve---------------gaQSYALELID 80  Helicobacter pylor...
2IQX_A     24 ALRVdyg----gvTVDelGKVltp--------------tqvMNRPsSISWDGld---------------pgKLYTLVLTD 70  Norway rat
Feature 1     #            # #                                                                
1FUX_A     55 PDap-----tgSGWWHWTVVNIPatvtylpvda---grrdgtklptGAVQGRndf-------------------gyaGFG 107 Escherichia coli
1B7A_A     70 PDapsrkdpkyREWHHFLVVNMKgnn------------------isSGTVLS-------------------------DYV 106 Bos taurus
1BEH_A     71 PDapsrkdpkyREWHHFLVVNMKgnd------------------isSGTVLS-------------------------DYV 107 human
1FJJ_A     54 PDap-----tgSGWWHWVVVNLPadtrvlpqgf----gsglvaxpdGVLQTRtdf-------------------gktGYD 105 Escherichia coli
1KN3_A     67 PDapsrkkpvyREWHHFLVVNMKgnd------------------isSGNVLS-------------------------DYV 103 house mouse
1QOU_A     77 PDvpgpsdpylREHLHWIVTDIPgtt-----------------dssFGKEVV-------------------------SYE 114 snapdragon
1WKP_A     75 PDvpspsnphlREYLHWLVTDIPatt-----------------gttFGNEIV-------------------------SYE 112 thale cress
1WPX_B     96 PDapsktdhkwSEFCHLVECDLKllneathetsgateffasefntkGSNTLI-------------------------EYM 150 baker's yeast
2EVV_A     81 HDaqk---vcgXPFVHWVVGNIAhnvleen----------asxxdkRIVQGVnsltqgfirsplnesekqrsnlnnsVYI 147 Helicobacter pylor...
2IQX_A     71 PDapsrkdpkfREWHHFLVVNMKgnd------------------isSGTVLS-------------------------EYV 107 Norway rat
Feature 1      ####     # #                                                      
1FUX_A    108 GACPPkgdKPHHYQFKVWALktekipvd-----------snssgalVGYXLNANki--atAEITPVY 161 Escherichia coli
1B7A_A    107 GSGPPkgtGLHRYVWLVYEQegplkcdepils---nrsgdhrgkfkVASFRKKYelgapvAGTCYQA 170 Bos taurus
1BEH_A    108 GSGPPkgtGLHRYVWLVYEQdrplkcdepils---nrsgdhrgkfkVASFRKKYelrapvAGTCYQA 171 human
1FJJ_A    106 GAAPPk-gETHRYIFTVHALdieridvd-----------egasgaxVGFNVHFHsl--asASITAXF 158 Escherichia coli
1KN3_A    104 GSGPPkgtGLHRYVWLVYQQdkplrcdepilt---nrsgdhrgkfkTAAFRKKYhlgapvAGTCYQA 167 house mouse
1QOU_A    115 MPRPNi--GIHRFVFLLFKQkkrgqamlsp-------pvvcrdgfnTRKFTQENelglpvAAVFFNC 172 snapdragon
1WKP_A    113 NPSPTa--GIHRVVFILFRQlgrqtvya----------pgwrqnfnTREFAEIYnlglpvAAVFYNS 167 thale cress
1WPX_B    151 GPAPPkgsGPHRYVFLLYKQpkgvdsskfskikdrpnwgygtpatgVGKWAKENnlq-lvASNFFYA 216 baker's yeast
2EVV_A    148 GPXPPn--GDHHYLIQVYALdipklalk-----------apfflgdLHDKXRNHii--aiGRKEFLY 199 Helicobacter pylori 26695
2IQX_A    108 GSGPPkdtGLHRYVWLVYEQeqplncdepils---nksgdnrgkfkVEEFRKKYhlgapvAGTCFQA 171 Norway rat

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