154L,2DQA,1XJT,1LMQ,1XSF,1D9U,1SLY,1D0K


Conserved Protein Domain Family
Lyz-like
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cd00442: Lyz-like 
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lysozyme-like domains
This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.
Links
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Statistics
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PSSM-Id: 381596
Aligned: 22 rows
Threshold Bit Score: 35.8486
Created: 16-Aug-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic residue [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:residue involved in cleavage of beta-1,4-glycosidic bond
  • Comment:some members require a second Asp/Glu for activity
  • Citation:PMID 7548026
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                       
154L_A      65 VIAGIISREShagkvlk---------------------------ngwgdrGNGFGlmQVDkrshkp-------------- 103  western graylag ...
2DQA_A      11 CLLCMCKLESggckpig---------------------------crmdvgSLSCGyfQIKqpywidcgkpgk-----dwk 58   Ruditapes philip...
1XJT_A      34 GLELIGNAEGcrrdpy-----------------------------xcpagVWTDGi-GNThgvtpgv------------- 70   Enterobacteria p...
1LMQ_A      27 NWVCLSKWESsyntqat---------------------------nrntdgSTDYGifQINsrywcddgrtpgaknvcgir 79   rainbow trout
1XSF_A      30 IWDAIAGCEAggnwa-------------------------------intgNGYYGgvQFDqgtweanggl--------ry 70   Mycobacterium tu...
1D9U_A      11 FLDMLAWSEGtdngrqktrnhgydvivggelftdysdhprklvtlnpklkSTGAGryQLLsrwwdayrk----------- 79   bacteriophage la...
AAM49603  1853 NIISLIQHESggnagitqss--------------------slrdinvlqgNPAKGllQYIpqtfrhy------------- 1899 Staphylococcus a...
Q54F36      44 TMLCISYYEStyntq------------------------------ainptSKAAGlfQILpehcgelckt---------c 84   Dictyostelium di...
Q8N1E2      85 VIAGVLSRKSpgdki-------------------------------lvnmGDRTSmvQDPgsqaptsw------------ 121  human
P0AEZ8     117 ELVLLPIVESafdph-------------------------------atsgANAAGiwQIIpstgrnyglk--------qt 157  Escherichia coli

Feature 1                         
154L_A     104 ---qgtwnGEVHITQGTTI 119  western graylag goose
2DQA_A      59 scsndincSSKCVQQYMKR 77   Ruditapes philippinarum
1XJT_A      71 --rktdqqIAADWEKNILI 87   Enterobacteria phage P1
1LMQ_A      80 csqlltddLTVAIRCAKRV 98   rainbow trout
1XSF_A      71 apradlatREEQIAVAEVT 89   Mycobacterium tuberculosis
1D9U_A      80 qlglkdfsPKSQDAVALQQ 98   bacteriophage lambda
AAM49603  1900 -avrghnnIYSGYDQLLAF 1917 Staphylococcus aureus bacteriophage phi 3A
Q54F36      85 ttpsdllnPTINTECAKSI 103  Dictyostelium discoideum AX4
Q8N1E2     122 isesqvsqTTEVLTTRIKE 140  human
P0AEZ8     158 rnydarrdVVASTTAALNM 176  Escherichia coli

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