1I6T,1UDE,1E9G,1E6A,2PRD,1QEZ


Conserved Protein Domain Family
pyrophosphatase

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cd00412: pyrophosphatase 
Click on image for an interactive view with Cn3D
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
Statistics
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PSSM-Id: 238239
Aligned: 90 rows
Threshold Bit Score: 158.794
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding sites [ion binding site]
Evidence:
  • Structure:1E9G_A:yeast inorganic pyrophosphatase
  • Structure:1I6T_A:E.Coli inorganic pyrophosphatase with CaPPi bound

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                                                             
1I6T_A     13 EDIYVVIEIPANadpIKYEIDKes--gALFVD---------RFMst---amFYPCNYGYINHTLSL-------------- 64  Escherichia coli
1E9G_B     41 NIFNMVVEIPRWt-nAKLEITKeetlnPIIQDtkk---galRFVrncfphhGYIHNYGAFPQTWEDpnvshp-------- 108 baker's yeast
CAC42762   83 GHLHYICEIPKEt-sAKMEVATdeprtPIKQDvkk---gklRFYp-----yNINWNYGMLPQTWEDpghtda-------- 145 Chlamydomonas rein...
AAP74702  222 NRYNFICEIPKWt-rAKFEIATgesfnPIKQDikn---gvpRFYkh----gDMMWNYGAFPQTWEStevlfe-------- 285 Trypanosoma brucei
XP_467983  89 GVFHFVVEIPKEs-sAKMEVATdesftPIKQDtkk---gnlRYYp-----yNINWNYGLFPQTWEDptlantd------- 152 Japanese rice
AAM64828  103 GVFNFIVEIPKEs-kAKMEVATdedftPIKQDtkk---gklRYYp-----yNINWNYGLLPQTWEDpshanse------- 166 thale cress
NP_473275 121 GTYNMIVEITKYn-yIKLEIQLrekfnVIKQDkkk---gklRYYh-----nSIYWNYGALPQTYEYpkhiyqnkskknke 191 Plasmodium falcipa...
EAK87613  144 LLYNMIIEIPKLt-nKKFEINTkeeytPLYQDrkl---erlRTYp-----gPIPWNYGAFPQTWEDpnkkgde------n 208 Cryptosporidium pa...
EAL44058   50 DVVNMVCEIPRGt-nAKMEISTtnkfnPIKQDlnkd--gslRYMkh----gNVLNHYGAVPQTWEDlferds-------- 114 Entamoeba histolyt...
AAX79455   64 SVITFVCEIPRRt-rAKLELVKeephnPIAQDtlkkegnalRFFky----gDVPFNYGFAPQTWEDpsvmdq-------- 130 Trypanosoma brucei
Feature 1           #    #                          #    #                                    
1I6T_A     65 ------DGDPVDVLVPTpYPLQPGSVTRCRPVGVLKMTDEAGEDAKLVAVPHsklskeyDHIKDVNDLp---eLLKAQIA 135 Escherichia coli
1E9G_B    109 etkavgDNDPIDVLEIGeTIAYTGQVKQVKALGIMALLDEGETDWKVIAIDIndp--laPKLNDIEDVekyfpGLLRATN 186 baker's yeast
CAC42762  146 tlgaagDNDPVDVVEIGaAAAKRGGVYKVKPVGVLAMIDDGELDWKVIAISAddp--kaALCNDVEDVekhfpGEIQKVL 223 Chlamydomonas rein...
AAP74702  286 -agvtgDNDPVDAVEIGmTQFKVGQVSAVKVLGVLGMIDEGKMDWKVVCISHndp--icRFMKDIHDVpkflpGCLDAIR 362 Trypanosoma brucei
XP_467983 153 vegafgDNDPVDVVEIGeRRANIGDVLKVKPLAALAMIDEGELDWKIVAISLddp--kaSLVNDVDDVekhfpGTLTAIR 230 Japanese rice
AAM64828  167 vegcfgDNDPVDVVEIGeTQRKIGDILNIKPLAALAMIDEGELDWKIVAISLddp--kaHLVNDVEDVekhfpGTLTAIR 244 thale cress
NP_473275 192 allftgDNDPLDILDIGsACLKIGQVVPVKILGAFTLIDEGELDWKIIAINKedk--hyEDINSLSDIekyypHTLSLLL 269 Plasmodium falcipa...
EAK87613  209 vdfshgDNDPLDAVEIGvGPLPRGTIIQVKILGCLALIDDDELDWKVVCIRVcdp--haSQLNDITDVekyfpGTIDRIR 286 Cryptosporidium pa...
EAL44058  115 ivgipgDNDPIDIIDISqKKVARGEIVQIKPICALALLDGGETDWKVIGINVndp--laQTITSANDIe----KTVDEIR 188 Entamoeba histolyt...
AAX79455  131 lttcggDGDPIDIVELSsNPFAVGSVRAVRVLGLLGLIDEGETDWKVITEAIgpd--atGTYGSLNNVp---qELKATIV 205 Trypanosoma brucei
Feature 1                                              
1I6T_A    136 HFFEHYKDLEKgKWVKVe------gWENAEAAKAEIVASFE 170 Escherichia coli
1E9G_B    187 EWFRIYKIPDGkPENQFafs---geAKNKKYALDIIKETHD 224 baker's yeast
CAC42762  224 EWFRDYKIPDGkPANKFgyd---nkCMNKEFTLNVIKETHE 261 Chlamydomonas reinhardtii
AAP74702  363 EWFRVYKICQGgEASHFafd---geFKDKEYAMKVIDESHN 400 Trypanosoma brucei
XP_467983 231 DWFRDYKIPDGkPANRFglg---nkPTSKEYALKVIEETNE 268 Japanese rice
AAM64828  245 DWFRDYKIPDGkPANRFglg---dkPANRDYALKIIQETNE 282 thale cress
NP_473275 270 EWFRSYKMADTkKLNLIsk-----qLYDKKESEDLIMKTHH 305 Plasmodium falciparum 3D7
EAK87613  287 RWFGLYKAVENkDVAKVnmyghfgePQSAEFAHSVILETHH 327 Cryptosporidium parvum
EAL44058  189 EWYRVYKVAEGkKLNKYayg---gkAFNQKSTLDIINETHL 226 Entamoeba histolytica HM-1:IMSS
AAX79455  206 KWFREYKTADGkKPNEFvfg---geLRNADDALRVIEGGSR 243 Trypanosoma brucei

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