1PII,1DL3,1LBM,1V5X


Conserved Protein Domain Family
PRAI
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cd00405: PRAI 
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Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.
Links
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Statistics
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PSSM-Id: 238237
Aligned: 218 rows
Threshold Bit Score: 114.979
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1LBM; Thermotoga maritima PRAI with bound prduct analog rCdRP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # #                     #                                                      
1PII        257 NKVCGLTrGQDAKAAYDAgaIYGGLIFVa----tSPRcvnvEQAQEVMAAApl---------qYVGVFRNhd---iaDVV 320 Escherichia coli
1LBM_A        4 VKICGITnLEDALFSVESgaDAVGFVFYp----kSKRyispEDARRISVELppf-------vfRVGVFVNee---peKIL 69  Thermotoga maritima
NP_774653    33 TQIYEVAtPAEAEAISAIgvDHVGVLVGdg---aFPRelpvSEAAAVMEAIrgp-------svLSALFLSpd---vaMIE 99  Bradyrhizobium j...
Q8PRX4        3 IKVCGIKrVEDAVMAAYCgaDAIGLVVGrk--hnSDDfidkHLAQKIVRECppy-------isPVLVTELdd---aeEIS 70  Methanosarcina m...
CAF30560      3 IKICGIKtPEELRIVENYg-NATGVILEc----aSKRrigfETAKNLVNLA------------NIPVFAVstasdvsVWE 65  Methanococcus ma...
AAS96964     46 IQIAGVHdADEACLLARCgvHAVGLPLRlp--vnAEDid-eAAAARLVAGLppv-------itPVAITYMdd---adEAD 112 Desulfovibrio vu...
ABB37855     17 VQAAGVHdAREALVIAQSgiRCIGLPLRlp--vhTEDit-eHDAAALCRMLqtlppsaagpvcPVCITYLdt---aqDIR 90  Desulfovibrio de...
YP_394867     4 KQIYSLItYDESVKTMEAgaDHIGLVPMqdggvpAHRvpleTVDKIFAEAKrrg-------vvTVAIMLNkd---pkEML 73  Lactobacillus sa...
YP_460933     8 IQIAGVRdAAEALMMGDAgvTHLGFPLRla--vhREDls-eREAAAVIALLkps-------vePVLITYLqk---adSIV 74  Syntrophus acidi...
ZP_01390931   3 IKFCGTAsLADMRCAIDAgcDAVGFIMGvt--hqSSDfvtaAEAAKMVRRLppf-------vePVAVTHLqe---tqDLI 70  Methanoculleus m...

Feature 1                  # #                                                          #       
1PII        321 DKAKvlslAAVQLHGne---eQLYIDTLRealpahvAIWKALSVgetlpa-----------refqhvDKYVLDngqgg-- 384 Escherichia coli
1LBM_A       70 DVASyvqlNAVQLHGee---pIELCRKIAer----iLVIKAVGVsnerdme---------ralnyreFPILLDtktpeyg 133 Thermotoga maritima
NP_774653   100 RMARelrpPIVHLGAsnellaPDHVSALRrsl-pgvRFMRSVPVtgpealqv-------araydgivEWILLDshrvgdp 171 Bradyrhizobium j...
Q8PRX4       71 GLVHetgvTSVQLHSdc---tVDSIISLRktf-pniKIIKNFHVigpgviha-------mkpfesvvDAFILDtldland 139 Methanosarcina m...
CAF30560     66 NIIEftgtNYLQMHSdi---dQKAIDFIKney--gcFIMKSFKIpetstspeidaekiiseiesyevDRILLDtgkgc-- 138 Methanococcus ma...
AAS96964    113 AFCTmlgvGHLQLHGai---rVDEMARLRrlr-pdlFIIKSLVVrehggmdngetlmgdvqafaphvDAFITDtfapetg 188 Desulfovibrio vu...
ABB37855     91 DLCRmlgtAHVQLHGgi---pVHQLAALRamm-pglYIIKSLVVrqtetgkdnl----eeltgiidaTAQLVDayitdth 162 Desulfovibrio de...
YP_394867    74 DIAKrvrpDILHIAGmeytadQAFRDQLRavc-petELMQAVLVdgpeaver-------akeyakfsDYLLTDsglaadt 145 Lactobacillus sa...
YP_460933    75 RLCRilgvRIVQLHGni---sITELLRLRqna-pelAVIKSLIVrgnnqkelia----tascdarlvDAFITDtwdqqtg 146 Syntrophus acidi...
ZP_01390931  71 GLVKesrcTTLQVQNii---ePTELDAVRdal-pyvTIVKAVHVtdasavaa-------akryepyaDALLLDtrtrekl 139 Methanoculleus m...

Feature 1                                                            # ##                       
1PII        385 ---------sgqrfDWSLLNgqs---lgNVLLAGGLGaDNCVEAAQtg-caGLDFNSAVESq----pGIKDARLLASVFQ 447 Escherichia coli
1LBM_A      134 --------gsgktfDWSLILpyrd-rfrYLVLSGGLNpENVRSAIDvvrpfAVDVSSGVEAf----pGKKDHDSIKMFIK 200 Thermotoga maritima
NP_774653   172 q-----igaqgvthDWSISRtivetvrtPVILAGGLGpDNVKEAIRsvqpaGVDSKTKTDSeg---tHSKDLVKVQAFNR 243 Bradyrhizobium j...
Q8PRX4      140 k-----vgstglvhDWSISRkivkevsrPVILAGGLTpENVGEAIRvvnpyGVDASSGLKDs----nGFKDEMKVINFVH 210 Methanosarcina m...
CAF30560    139 ----------gqthDHRVSQiia--kkfDIVLAGGLDpDNVLNIVKyvkpfGIDVSSGVENn-----NSKDEELIKRFCE 201 Methanococcus ma...
AAS96964    189 a-----sgatgkthDWAVSAalvrlsprPVILAGGLHpGNVREAVRrvcpaGVDAHTGVEGp----dGRKDEGLVRRFVA 259 Desulfovibrio vu...
ABB37855    163 dpasgadgatgkthDWRTSRalvrrsplPVILAGGLTpQNVRQAVLtvrpaGVDAHTGLENp----aGRKDPALCHEFAR 238 Desulfovibrio de...
YP_394867   146 g-----igasglthDWSIDAaivanvdiPVIIAGGLGpDNVEECIKeikpyGVDSLTKTSIkydggrMEKDIDKVREFCE 220 Lactobacillus sa...
YP_460933   147 a-----cgatgkvhDWKISRlladcspkPLILAGGLGpENVRQAILevrpaGVDSHTGVEGp----dGRKDEGRVRAFVA 217 Syntrophus acidi...
ZP_01390931 140 -------ggtgiphDWNISAaivanstiPVILAGGLTpENVREAIRkvrpyGVDVHTGVRKd-----GVRNPERTLAFAR 207 Methanoculleus m...

Feature 1         
1PII        448 TL 449 Escherichia coli
1LBM_A      201 NA 202 Thermotoga maritima
NP_774653   244 AA 245 Bradyrhizobium japonicum USDA 110
Q8PRX4      211 RA 212 Methanosarcina mazei
CAF30560    202 NV 203 Methanococcus maripaludis S2
AAS96964    260 EA 261 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
ABB37855    239 QA 240 Desulfovibrio desulfuricans G20
YP_394867   221 RA 222 Lactobacillus sakei subsp. sakei 23K
YP_460933   218 EA 219 Syntrophus aciditrophicus SB
ZP_01390931 208 EA 209 Methanoculleus marisnigri JR1

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