1I50,1I3Q,1IW7,4A3G,4B1O 4B1P,3LU0


Conserved Protein Domain Family
RNAP_largest_subunit_N
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cd00399: RNAP_largest_subunit_N 
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Largest subunit of RNA polymerase (RNAP), N-terminal domain
This region represents the N-terminal domain of the largest subunit of RNA polymerase (RNAP). RNAP is a large multi-protein complex responsible for the synthesis of RNA. It is the principle enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei; RNAP I transcribes the ribosomal RNA precursor, RNAP II the mRNA precursor, and RNAP III the 5S and tRNA genes. A single distinct RNAP complex is found in prokaryotes and archaea, respectively, which may be responsible for the synthesis of all RNAs. Structure studies reveal that prokaryotic and eukaryotic RNAPs share a conserved crab-claw-shaped structure. The largest and the second largest subunits each make up one clamp, one jaw, and part of the cleft. All RNAPs are metalloenzymes. At least one Mg2+ ion is bound in the catalytic center. In addition, all cellular RNAPs contain several tightly bound zinc ions to different subunits that vary between RNAPs from prokaryotic to eukaryotic lineages. This domain represents the N-terminal region of the largest subunit of RNAP, and includes part of the active site. In archaea and some of the photosynthetic organisms or cellular organelle, however, this domain exists as a separate subunit.
Links
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Statistics
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PSSM-Id: 259843
Aligned: 9 rows
Threshold Bit Score: 567.832
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site region [active site]
Evidence:
  • Structure:4A3G_A; Yeast Rpb1, the active site is organized around a catalytic Mg and 2nt DNA-RNA hybrid, contact at 4.0
  • Comment:A complex active site region of DNA-dependent RNA polymerases mainly formed by Rpb1 and Rpb2 subunits, including Mg binding site, Bridge Helix, Switch and Funnel domains
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1I50_A        22 FSPEEVRAISVAKIRFPetmdetqtrakigg------------------lndprlgsidrnlkCqTCqeg-mneCPGHFG 82   baker's yeast
1I3Q_A        22 FSPEEVRAISVAKIRFPetmdetqtrakigg------------------lndprlgsidrnlkCqTCqeg-mneCPGHFG 82   baker's yeast
1IW7_D        13 ASPEKIRSWSYGEVEKPetinyrtlkperdglfderifgpikdyecacgkykrqrfegkvcerCgVEvtk-sivRRYRMG 91   Thermus thermo...
4A3G_A        22 FSPEEVRAISVAKIRFPetmdetqtrakigg------------------lndprlgsidrnlkCqTCqeg-mneCPGHFG 82   baker's yeast
4B1O 4B1P_4   14 LSPDEIRKMSVTAIITPdvydedgtpiegsv-------------------mdprlgviepgqkCpTCgnt-lgnCPGHFG 73   Sulfolobus shi...
NP_191325     35 MTEQDVRKHSFLKVTSPilhdnvgnpfpggl-------------------ydlklgpkddkqaCnSCgql-klaCPGHCG 94   thale cress
CAG31495      23 KSPEEMRQQAHIQVVSKnlysqdnhhaplqyg-----------------vldhrmgtsekdrpCeTCgkn-ladCLGHYG 84   chicken
CAH66955      23 MTSSDMEKLSSATIIEMcdvtnakl------------------------------glpngapqCaTCgsrsirdCDGHFG 72   Indian rice
3LU0_D        25 ASPDMIRSWSFGEVKKPetinyrtfkperdglfcarifgpvkdyeclcgkykrlkhrgvicekCgVEvtq-tkvRRERMG 103  Escherichia co...

Feature 1                                                                                        
1I50_A        83 HIDLAKPVFHVGFIAKIKKVCEcvcmhcgkllldehnelmrqalaikdskkrfaaiwtlcktkmvcetdvpseddptqlv 162  baker's yeast
1I3Q_A        83 HIDLAKPVFHVGFIAKIKKVCEcvcmhcgkllldehnelmrqalaikdskkrfaaiwtlcktkmvcetdvpseddptqlv 162  baker's yeast
1IW7_D        92 HIELATPAAHIWFVKDVPSKIGtlldlsateleqvlyfskyivldpkgailngvpvekrqlltdeeyrelrygkqetypl 171  Thermus thermo...
4A3G_A        83 HIDLAKPVFHVGFIAKIKKVCEcvcmhcgkllldehnelmrqalaikdskkrfaaiwtlcktkmvcetdvpseddptqlv 162  baker's yeast
4B1O 4B1P_4   74 HIELVRPVIHVGFVKHVYEFLKatcrrcgrvkisedeiekysriynaikkrwpsaarrlteyvkktamkaqvcphc---- 149  Sulfolobus shi...
NP_191325     95 HIELVFPIYHPLLFNLLFNFLQracffchhfmakpedveravsqlkliikgdivsakqlesntptkskssdescesvvtt 174  thale cress
CAG31495      85 YIDLELPCFHVGYFKAVIGILQmicktccrimlsveekkqfldylkrpgltylqkrglkkkvsekcrkkntcpycgafng 164  chicken
CAH66955      73 VIKLAATVHNSYFIEEVVQLLNqicpgcltlkqngdtkkadgttiqgtckycskdgsklypsiifkmltsprvtlsrskl 152  Indian rice
3LU0_D       104 HIELASPTAHIWFLKSLPSRIGllldmplrdiervlyfesyvvieggmtnlerqqilteeqyldaleefgdefdak---- 179  Escherichia co...

Feature 1                                                                                        
1I50_A       163 srggc--------------------------------------------------------------------------- 167  baker's yeast
1I3Q_A       163 srggc--------------------------------------------------------------------------- 167  baker's yeast
1IW7_D       172 ppgvdalvkdgeevvkgqelapgvvsrldgvalyrfprrvrveyvkkeraglrlplaawvekeaykpgeilaelpepylf 251  Thermus thermo...
4A3G_A       163 srggc--------------------------------------------------------------------------- 167  baker's yeast
4B1O 4B1P_4      --------------------------------------------------------------------------------      Sulfolobus shi...
NP_191325    175 dsseecedsdvedqrwtslqfaevtavlknfmrlsskscsrckginpklekpm--------------------------- 227  thale cress
CAG31495     165 tvkkcgllkiih-------------------------------------------------------------------- 176  chicken
CAH66955     153 hrntsvmdkms--------------------------------------------------------------------- 163  Indian rice
3LU0_D           --------------------------------------------------------------------------------      Escherichia co...

Feature 1                                                                                        
1I50_A           --------------------------------------------------------------------------------      baker's yeast
1I3Q_A           --------------------------------------------------------------------------------      baker's yeast
1IW7_D       252 raeeegvvelkeleegaflvlrredepvatyflpvgmtplvvhgeivekgqplaeakgllrmprqvraaqveaeeegetv 331  Thermus thermo...
4A3G_A           --------------------------------------------------------------------------------      baker's yeast
4B1O 4B1P_4      --------------------------------------------------------------------------------      Sulfolobus shi...
NP_191325        --------------------------------------------------------------------------------      thale cress
CAG31495         --------------------------------------------------------------------------------      chicken
CAH66955         --------------------------------------------------------------------------------      Indian rice
3LU0_D           --------------------------------------------------------------------------------      Escherichia co...

Feature 1                                                                                        
1I50_A           --------------------------------------------------------------------------------      baker's yeast
1I3Q_A           --------------------------------------------------------------------------------      baker's yeast
1IW7_D       332 yltlflewtepkdyrvqphmnvvvpegarveagdkivaaidpeeeviaeaegvvhlhepasilvvkarvypfeddvevst 411  Thermus thermo...
4A3G_A           --------------------------------------------------------------------------------      baker's yeast
4B1O 4B1P_4      --------------------------------------------------------------------------------      Sulfolobus shi...
NP_191325    228 -------------------------------------------------------------------fgwvrmramkdsd 240  thale cress
CAG31495         --------------------------------------------------------------------------------      chicken
CAH66955         --------------------------------------------------------------------------------      Indian rice
3LU0_D           --------------------------------------------------------------------------------      Escherichia co...

Feature 1                                                                                        
1I50_A       168 ----------------------------------gntqptirkdglklvgswkkdratgdadepelrvlsteeilnifkh 213  baker's yeast
1I3Q_A       168 ----------------------------------gntqptirkdglklvgswkkdratgdadepelrvlsteeilnifkh 213  baker's yeast
1IW7_D       412 gdrvapgdvladggkvksdvygrvevdlvrnvvrvvesydidarmgaeaiqqllkeldlealekelleemkhpsrarrak 491  Thermus thermo...
4A3G_A       168 ----------------------------------gntqptirkdglklvgswkkdratgdadepelrvlsteeilnifkh 213  baker's yeast
4B1O 4B1P_4  150 -------------------------------------------gekqfkiklekpynfyeerkegvakltpsdirerlek 186  Sulfolobus shi...
NP_191325    241 vganvirglklkkstssvenpdgfddsgidalsevedgdketrekstevaaefeehnskrdllpsevrnilkhlwqnehe 320  thale cress
CAG31495     177 ---------------------------ekyktnkkvvdpivstflqsfetaiehnkevepllgraqenlnplvvlnlfkr 229  chicken
CAH66955     164 ----------------------------iiaevaggvahksknkaphetlpqdfwdfipddnqppifnvtkkilspyqvf 215  Indian rice
3LU0_D       180 -------------------------------------------mgaeaiqallksmdleqeceqlreelnetnsetkrkk 216  Escherichia co...

Feature 1                                                                                        
1I50_A       214 isvkdftslgfnevfsrPEWMILTCLPVPPPPVRPSIsfnesqrgeddltfkladi-lkanisletlehngaphhAIEEA 292  baker's yeast
1I3Q_A       214 isvkdftslgfnevfsrPEWMILTCLPVPPPPVRPSIsfnesqrgeddltfkladi-lkanisletlehngaphhAIEEA 292  baker's yeast
1IW7_D       492 arkrlevvrafldsgnrPEWMILEAVPVLPPDLRPMVqvdggrfatsdlndlyrrl-inrnnrlkkllaqgapeiIIRNE 570  Thermus thermo...
4A3G_A       214 isvkdftslgfnevfsrPEWMILTCLPVPPPPVRPSIsfnesqrgeddltfkladi-lkanisletlehngaphhAIEEA 292  baker's yeast
4B1O 4B1P_4  187 vpesdveilgydpttsrPEWMILTVLPVPPITIRPSImiesgiraeddlthklvdi-vrinerlkesidagapqlIIEDL 265  Sulfolobus shi...
NP_191325    321 fcsfigdlwqsgsekidYSMFFLESVLVPPTKFRPPTtggdsvmehpqtvglnkv--iesnnilgnactnkldqsKVIFR 398  thale cress
CAG31495     230 ipaediplllmnpeagkPSDLILTRLLVPPLCIRPSVvsdlksgtneddltmklteiiflndvikkhrisgaktqMIMED 309  chicken
CAH66955     216 hmlkkldpelinqvtrrRELLFLSCLPVTPNCHRVAEmpyghs---------------------------dgprlAFDDR 268  Indian rice
3LU0_D       217 ltkriklleafvqsgnkPEWMILTVLPVLPPDLRPLVpldggrfatsdlndlyrrv-inrnnrlkrlldlaapdiIVRNE 295  Escherichia co...

Feature 1                                               #    #      #     #                      
1I50_A       293 ESllQFHVATYMDndiagqpqalqksgrpvkSIRARLKGKEGRIRGNLmGKRVDFSARTVISGDPNLELDQVGVPKSIAK 372  baker's yeast
1I3Q_A       293 ESllQFHVATYMDndiagqpqalqksgrpvkSIRARLKGKEGRIRGNLmGKRVDFSARTVISGDPNLELDQVGVPKSIAK 372  baker's yeast
1IW7_D       571 KRmlQEAVDALLDngrrgapvtnpgsdrplrSLTDILSGKQGRFRQNLlGKRVDYSGRSVIVVGPQLKLHQCGLPKRMAL 650  Thermus thermo...
4A3G_A       293 ESllQFHVATYMDndiagqpqalqksgrpvkSIRARLKGKEGRIRGNLmGKRVDFSARTVISGDPNLELDQVGVPKSIAK 372  baker's yeast
4B1O 4B1P_4  266 WDllQYHVATYFDneipglppskhrsgrplrTLAQRLKGKEGRFRGNLsGKRVDFSSRTVISPDPNISIDEVGVPEIIAR 345  Sulfolobus shi...
NP_191325    399 WRnlQESVNVLFDsktatvq-----sqrdssGICQLLEKKEGLFRQKMmGKRVNHACRSVISPDPYIAVNDIGIPPCFAL 473  thale cress
CAG31495     310 WDflQLQCALYINselsgipln-mapkkwtrGFVQRLKGKQGRFRGNLsGKRVDFSGRTVISPDPNLRIDEVAVPIHVAK 388  chicken
CAH66955     269 TKayKRMVDLYSKksd------------desSASTDTYGIKWLKDIIL-SKRSDNAFRSIMVGDPKINLNEIGIPMGLAL 335  Indian rice
3LU0_D       296 KRmlQEAVDALLDngrrgrait-gsnkrplkSLADMIKGKQGRFRQNLlGKRVDYSGRSVITVGPYLRLHQCGLPKKMAL 374  Escherichia co...

Feature 1                                                                                        
1I50_A       373 TLtypevvtpynidrltqlvrngpnehpgakyvi-------------------rdsgdridlryskragdiqlqygwkve 433  baker's yeast
1I3Q_A       373 TLtypevvtpynidrltqlvrngpnehpgakyvi-------------------rdsgdridlryskragdiqlqygwkve 433  baker's yeast
1IW7_D       651 ELfkpfllkkmeekgiapnvkaar---------------------------------------rmlerqrdikdevwdal 691  Thermus thermo...
4A3G_A       373 TLtypevvtpynidrltqlvrngpnehpgakyvi-------------------rdsgdridlryskragdiqlqygwkve 433  baker's yeast
4B1O 4B1P_4  346 TLtvperitpwnieklrqfvingpdkwpganyvir-----------------pdgrridlryvkdrkelastlapgyvve 408  Sulfolobus shi...
NP_191325    474 KLtypervtpwnveklreaiingpdihpgathysdksstmklpstekarraiarkllssrgattelgktcdinfegktvh 553  thale cress
CAG31495     389 ILtfpekvnkaninfmrklvrngpdvhpganfiqq-----------------rhtqmkrflkygnrekmaqelkfgdive 451  chicken
CAH66955     336 NLvvseqvssynfetinlkcnlhlltkevl--------------------------lvrrngnlifvrkanqleigdiay 389  Indian rice
3LU0_D       375 ELfkpfiygklelrglattika------------------------------------------akkmvereeavvwdil 412  Escherichia co...

Feature 1                    ###                                 # # #                           
1I50_A       434 rhimDNDPVLFNRQPslHKMSMMAHRVKVIPy-STFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIV 512  baker's yeast
1I3Q_A       434 rhimDNDPVLFNRQPslHKMSMMAHRVKVIPy-STFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIV 512  baker's yeast
1IW7_D       692 eeviHGKVVLLNRAPtlHRLGIQAFQPVLVEg-QSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLL 770  Thermus thermo...
4A3G_A       434 rhimDNDPVLFNRQPslHKMSMMAHRVKVIPy-STFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIV 512  baker's yeast
4B1O 4B1P_4  409 rhltDGDVVLFNRQPslHRISMMAHRVRVLKg-LTFRLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNII 487  Sulfolobus shi...
NP_191325    554 rhmrDGDIVLVNRQPtlHKPSLMAHKVRVLKgeKTLRLHYANCSTYNADFDGDEMNVHFPQDEISRAEAYNIVNANNQYA 633  thale cress
CAG31495     452 rhliDGDIVLFNRQPslHKLSIMAHIARVKPh-RTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLV 530  chicken
CAH66955     390 rllqDGDLVLVNRPPsvHQHSLIALSAKLLStqSAVSINPLCCDPFKGDFDGDCLHGYIPQCLQSRIELEELVSLSGQLL 469  Indian rice
3LU0_D       413 deviREHPVLLNRAPtlHRLGIQAFEPVLIEg-KAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNIL 491  Escherichia co...

Feature 1                                                                                        
1I50_A       513 SPQSNKPCMGIVQDTLCGIRKLTLrdtfieldqvlnmlywvpd------------------------------------- 555  baker's yeast
1I3Q_A       513 SPQSNKPCMGIVQDTLCGIRKLTLrdtfieldqvlnmlywvpd------------------------------------- 555  baker's yeast
1IW7_D       771 SPASGEPLAKPSRDIILGLYYITQvrkekkgaglefatpeealaahergevalnapikvagretsvgrlkyvfanpdeal 850  Thermus thermo...
4A3G_A       513 SPQSNKPCMGIVQDTLCGIRKLTLrdtfieldqvlnmlywvpd------------------------------------- 555  baker's yeast
4B1O 4B1P_4  488 TPRYGGPIIGAAQDYISGAYLLTVkttlltkeeaqqilgvad-------------------------------------- 529  Sulfolobus shi...
NP_191325    634 RPSNGEPLRALIQDHIVSSVLLTKrdtfldkdhfnqllfssgvtdmvlstfsgr-------------------------- 687  thale cress
CAG31495     531 TPRNGEPLIAAIQDFLTGAYLLTLkdtffdrakacqiiasilvgk----------------------------------- 575  chicken
CAH66955     470 NQQDGRSLVSLTHDSLAAAHQLTNadvflekaefqqlqmlsssi------------------------------------ 513  Indian rice
3LU0_D       492 SPANGEPIIVPSQDVVLGLYYMTRdcvnakgegmvltgpkeaerlyrsglaslhar------------------------ 547  Escherichia co...

Feature 1                                                                                        
1I50_A       556 -------------wdgviptpaiikpkplwsGKQILSVAIPngihlqrfdegttllspkdngm----------------- 605  baker's yeast
1I3Q_A       556 -------------wdgviptpaiikpkplwsGKQILSVAIPngihlqrfdegttllspkdngm----------------- 605  baker's yeast
1IW7_D       851 lavahgivdlqdvvtvrymgkrletspgrilFARIVAEAVEdekvaweliq----------------------------- 901  Thermus thermo...
4A3G_A       556 -------------wdgviptpaiikpkplwsGKQILSVAIPngihlqrfdegttllspkdngm----------------- 605  baker's yeast
4B1O 4B1P_4  530 -------------vkidlgepailapreyytGKQVVSAFLPkdfnfhgqanvssgprlcknedcphd------------- 583  Sulfolobus shi...
NP_191325    688 --sgkkvmvsasdaelltvtpailkpvplwtGKQVITAVLNqitkghppftvekatklpvdffkcrsrevkpnsgdltkk 765  thale cress
CAG31495     576 ----------dekikvrlpppailkpvtlwtGKQVFSSILKpsddcpvkanlrtkgkqycgkgedlcy------------ 633  chicken
CAH66955     514 -----------sltpmpsvfkstnsqgplwtGKQLFGMLLPygmnisfdqklhikds----------------------- 559  Indian rice
3LU0_D       548 vkvriteyekdangelvaktslkdttvgraiLWMIVPKGLPysivnqa-------------------------------- 595  Escherichia co...

Feature 1                                                                                        
1I50_A       606 --------------liidgqiifgvvekktvgssnGGLIHVVTREkgpQVCAKLFGNIQKVVNFWLLHngfstgigdtia 671  baker's yeast
1I3Q_A       606 --------------liidgqiifgvvekktvgssnGGLIHVVTREkgpQVCAKLFGNIQKVVNFWLLHngfstgigdtia 671  baker's yeast
1IW7_D       902 -------------------------ldvpqeknslKDLVYQAFLRlgmEKTARLLDALKYYGFTFSTTsgitig----id 952  Thermus thermo...
4A3G_A       606 --------------liidgqiifgvvekktvgssnGGLIHVVTREkgpQVCAKLFGNIQKVVNFWLLHngfstgigdtia 671  baker's yeast
4B1O 4B1P_4  584 ----------syvvikngillegvfdkkaignqqpESILHWLIKEysdEYGKWLMDNLFRVFIRFVELqgftmrledvsl 653  Sulfolobus shi...
NP_191325    766 keideswkqnlnedklhirknefvcgvidkaqfadYGLVHTVHELygsNAAGNLLSVFSRLFTVFLQThgftcgvddlii 845  thale cress
CAG31495     634 --------ndsyvtiqnselmsgsmdkgtlgsgskNNIFYILLRDwgqVEAADAMSRLARLAPVYLSNrgfsigigdvtp 705  chicken
CAH66955     560 --------------------evltcssgsfwlqnnTSSLFSVMFKeygCKALEFLSSTQDVLCEFLTMwglsvsls-dly 618  Indian rice
3LU0_D       596 -----------------------------lgkkaiSKMLNTCYRIlglKPTVIFADQIMYTGFAYAARsgasvg----id 642  Escherichia co...

Feature 1                                                                                        
1I50_A       672 dgptMREITETIAEAKKKVLDVTKEAQANlltakhgmtlr----------------esfednvvrfLNEARDKAGRLAEV 735  baker's yeast
1I3Q_A       672 dgptMREITETIAEAKKKVLDVTKEAQANlltakhgmtlr----------------esfednvvrfLNEARDKAGRLAEV 735  baker's yeast
1IW7_D       953 daviPEEKKQYLEEADRKLLQIEQAYEMGfltdrer-----------------------ydqilqlWTETTEKVTQAVFK 1009 Thermus thermo...
4A3G_A       672 dgptMREITETIAEAKKKVLDVTKEAQANlltakhgmtlr----------------esfednvvrfLNEARDKAGRLAEV 735  baker's yeast
4B1O 4B1P_4  654 gddvKKEIYNEIDRAKVEVDNLIQKYKNGelepipgrtle----------------eslenyildtLDKLRSTAGDIASK 717  Sulfolobus shi...
NP_191325    846 lkdmDEERTKQLQECENVGERVLRKTFGIdvdvqidpqdmrsrierilyedgesalasldrsivnyLNQCSSKGVMNDLL 925  thale cress
CAG31495     706 gqglLKAKYELLHAGYKKCDEYIEALNTGklqqqpgctae----------------etlealilkeLSVIRDHAGSACLR 769  chicken
CAH66955     619 lfsdHYSRRKLSEEVHLALDEAEEAFQIKqillnsvsipnlkyydg---gddrsntdeqsgftqvsLPIIRSSMTSFKSV 695  Indian rice
3LU0_D       643 dmviPEKKHEIISEAEAEVAEIQEQFQSGlvtager-----------------------ynkvidiWAAANDRVSKAMMD 699  Escherichia co...

Feature 1                                                                                        
1I50_A       736 nlk---------------dlNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKriafgfvdrtlp--------------h 786  baker's yeast
1I3Q_A       736 nlk---------------dlNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKriafgfvdrtlp--------------h 786  baker's yeast
1IW7_D      1010 nfee------------nypfNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGet------------------------- 1052 Thermus thermo...
4A3G_A       736 nlk---------------dlNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKriafgfvdrtlp--------------h 786  baker's yeast
4B1O 4B1P_4  718 yld---------------pfNFAYVMARTGARGSVLNITQMAAMLGQQSVRGErikrgymtrtlp--------------h 768  Sulfolobus shi...
NP_191325    926 sdgll----------ktpgrNCISLMTISGAKGSKVNFQQISSHLGQQDLEGKrvprmvsgktlp--------------c 981  thale cress
CAG31495     770 eld---------------ksNSPLIMALCGSKGSFINISQMIACVGQQAISGSrvpdgfenrslp--------------h 820  chicken
CAH66955     696 fndllkmv-----qqyvskdNSMMTMINSGSKGSVLKFVQQTACVGLQLPASKfpfripsqlscvswnrhkslnceitdg 770  Indian rice
3LU0_D       700 nlqtetvinrdgqeekqvsfNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGsi------------------------- 754  Escherichia co...

Feature 1                                                        ##                 
1I50_A       787 fskddyspeskGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKtaeTGYIQRRLVKALEDIMVHYD 853  baker's yeast
1I3Q_A       787 fskddyspeskGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKtaeTGYIQRRLVKALEDIMVHYD 853  baker's yeast
1IW7_D      1053 ---------feVPVRSSFREGLTVLEYFISSHGARKGGADTALRtadSGYLTRKLVDVTHEIVVREA 1110 Thermus thermophilus
4A3G_A       787 fskddyspeskGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKtaeTGYIQRRLVKALEDIMVHYD 853  baker's yeast
4B1O 4B1P_4  769 fkpydispearGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRtsqSGYMQRRLINALSDLRAEYD 835  Sulfolobus shibatae B12
NP_191325    982 fhpwdwspragGFISDRFLSGLRPQEYYFHCMAGREGLVDTAVKtsrSGYLQRCLMKNLESLKVNYD 1048 thale cress
CAG31495     821 fekhsklpaakGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKtaeTGYMQRRLVKSLEDLCSQYD 887  chicken
CAH66955     771 tsecvggqdmyAVIRNSFLDGLNPLECLLHAISGRANFFSENADv--PGTLTRKLMYHLRDTYVAYD 835  Indian rice
3LU0_D       755 ---------ieTPITANFREGLNVLQYFISTHGARKGLADTALKtanSGYLTRRLVDVAQDLVVTED 812  Escherichia coli K12

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