1CLI,1VK3,1T3T,2Z1T,1T3T,1VQV


Conserved Protein Domain Family
PurM-like

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cd00396: PurM-like 
Click on image for an interactive view with Cn3D
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Statistics
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PSSM-Id: 100027
View PSSM: cd00396
Aligned: 10 rows
Threshold Bit Score: 172.581
Threshold Setting Gi: 55669841
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:The N- and C-terminal repeats of PurL bind ATP/ADP
  • Structure:1T3T; Salmonella FGAR-AT with bound ADP, 3.5 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #   #                                            
1CLI_A        59 VLVSGTDGVGtklrlamdlkrhdTIGIDLVAMCVNDLVvqg---aepLFFLDYYATgkld-------------------- 115  Escherichia coli
1VK3_A        76 SVAFKIESHNhpsa-----iepyNGAATGVGGIIRDVLaxg---arpTAIFDSLHXsr---------------------- 125  Thermotoga mar...
1T3T_A       296 HILMKVETHNhpta-----ispwPGAATGSGGEIRDEGatgr-gakpKAGLVGFSVsnlripgfeqpweedfgkperivt 369  Salmonella typ...
2Z1T_A        50 PLAMSTDSYTvdpif----fpggDIGTLAVHGTVNDVSmlg---arpRYLSCGFILeegl-------------------- 102  Desulfovibrio ...
1T3T_A       700 GEAMSIGERApval-----ldfaASARLAVGEALTNIAatqigdikrIKLSANWMAaaghp------------------g 756  Salmonella typ...
ZP_01574817   45 ACVMSTDPITaa---------gkNAGRLAVHISCNDIAssg---vepLGLMVTILCpvgt-------------------- 92   Clostridium ce...
YP_448059     57 LMLLATDGIWgalmd----vnpwWAGYCSVLVNVNDIAamg---grpMGMTNVLSSsnp--------------------- 108  Methanosphaera...
P16456        62 SVISTTDFFMpivd------npfDFGRIAATNAISDIFamg---gkpIMAIAILGWpinkl------------------- 113  Escherichia coli
1VQV_B        37 KLLLTTDVLNegvhfl-rsyipeAVGWKAISVNVSDVIang---glpKWALISLNLpedl-------------------- 92   Aquifex aeolicus
AAB86000     137 YITTAVDGIHsrls-----eypfLGGFHVTRAALRDVCvmg---srpVALISDLHLaddg-------------------- 188  Methanothermob...
Feature 1                                 ###                                                    
1CLI_A       116 -vdtASAVISGIA-EGCLQSGCslVGGETAEmpgmy---------hgedYDVAGFCVGVVekseiid-gskvsdgDVLIA 183  Escherichia coli
1VK3_A       126 ---iIDGIIEGIA-DYGNSIGVptVGGELRIssly-----------ahnPLVNVLAAGVVrndxlvd-skasrpgQVIVI 189  Thermotoga mar...
1T3T_A       370 aldiMTEGPLGGA-AFNNEFGRpaLTGYFRTyeekvnshngeelrgyhkPIMLAGGIGNIradhvqk--geivvgAKLIV 446  Salmonella typ...
2Z1T_A       103 dmdiLERVVASMG-KAAREAGVfiVTGDTKVvprg----------acdkMFINTTGIGEIlvdpaps-gdrarpgDAILI 170  Desulfovibrio ...
1T3T_A       757 edagLYDAVKAVGeELCPQLGLtiPVGKDSMsmktrwqegneqremtspLSLVISAFARVedvrhtltpqlstedNALLL 836  Salmonella typ...
ZP_01574817   93 teteLEHLMDQVC-ETAGQLNVeiIGGHTEVtpav----------nkiiLSTTCVGKSLKdkiiss---sgakpgDSVIL 158  Clostridium ce...
YP_448059    109 --eiTAQIMDGIK-EGVKKFGVpmVGGHTHPdt--------------pyDALDVAISGIVdkdavip-scgavndDNVIV 170  Methanosphaera...
P16456       114 speiAREVTEGGR-YACRQAGIalAGGHSIDap---------------ePIFGLAVTGIVptervkk-nstaqagCKLFL 176  Escherichia coli
1VQV_B        93 evsyVERFYIGVK-RACEFYKCevVGGNISKse---------------kIGISVFLVGETerfvgr---dgarlgDSVFV 153  Aquifex aeolicus
AAB86000     189 dvgkLFDFTAGVA-AVSELVGVpvVAGSTLRvggdm--------vlgdrLVSAVGAIGFSetpptar--kraepgDVILL 257  Methanothermob...
Feature 1                                                                                        
1CLI_A       184 LGssgphsngyslvrkilevsgcdpqtteldgkpladhllaptriyVKSVLELiekv------------dvhAIAHLTgg 251  Escherichia coli
1VK3_A       190 FGgatgrdgihgasfasedltg-----dkatklsiqvgdpfaekxlIEAFLEXveeg------------lveGAQDLGag 252  Thermotoga mar...
1T3T_A       447 LGgpamniglgggaassmasgqs---dadldfasvqrdnpemerrcQEVIDRCwqlgd---------anpilFIHDVGag 514  Salmonella typ...
2Z1T_A       171 SGsmgdhgltilsqrqg---------------lnfaadvcsdsaslNRVVEKLvlev-----------gdihVLRDPTrg 224  Desulfovibrio ...
1T3T_A       837 IDlgkghnalgatalaqvyr--------qlgdkpadvrdvaqlkgfYDAMQALvaar------------kllAWHDRSdg 896  Salmonella typ...
ZP_01574817  159 TKsaglegtaiiagd------------------feeelaevmnkneLQYAKSLinaisvvpegvlagrfgvtSMHDITeg 220  Clostridium ce...
YP_448059    171 AIdldgdvypgteinwd--------------ttsdkspsyvqnqinVMETIGKkhl--------------vhAAKDISnp 222  Methanosphaera...
P16456       177 TKplgigvlttaekksl---------------lkpehqglatevmcRMNIAGAsfani----------egvkAMTDVTgf 231  Escherichia coli
1VQV_B       154 SGtlgdsraglelllxekee--------yepfelaliqrhlrptarIDYVKHIqky--------------anASXDISdg 211  Aquifex aeolicus
AAB86000     258 TEgsgggtittta----------------------iyhglfdvvweTLDVNFIraseaimd---sgllgdvhAMTDVTng 312  Methanothermob...
Feature 1                                                                                        
1CLI_A       252 gfwenIPRVLpd-nTQAVIDesswqwpevfnwlqta--------------------gnvehhemyrtfncgvGMIIALpa 310  Escherichia coli
1VK3_A       253 gvlsaTSELVakgnLGAIVHldrvplrepdxe-----------------------------pweilisesqeRXAVVTsp 303  Thermotoga mar...
1T3T_A       515 glsnaMPELVsdggRGGKFElrdilsdepgms-----------------------------pleiwcnesqeRYVLAVaa 565  Salmonella typ...
2Z1T_A       225 glattLNEIAgqsqAVCHVLetavpvresvrngc------------------------sflgldplylanegKLICILpe 280  Desulfovibrio ...
1T3T_A       897 gllvtLAEMAfaghCGVQVDiaalgddhl-----------------------------------aalfneelGGVIQVra 941  Salmonella typ...
ZP_01574817  221 gvlgaAWEIAeassTGVTIKkdsipvepvtrhic------------------------dhfginplrlissgCMIITCkd 276  Clostridium ce...
YP_448059    223 givgtLGMLLeasdMGAHIDlesiprandidw-----------------------------iswfkmypgsaFVLTAPee 273  Methanosphaera...
P16456       232 gllghLSEMCqgagVQARVDyeaipklpgveeyiklgavpggternfasyghlmgemprevrdllcdpqtsgGLLLAVmp 311  Escherichia coli
1VQV_B       212 l-vadANHLAqrsgVKIEILseklplsnelkxycek--------------------ygknpieyalfggedyQLLFTHpk 270  Aquifex aeolicus
AAB86000     313 glrgdAHEISstagVGLEFDadavmsminpsvlrm-----------------------lqdleidplgvsidSLMIIApe 369  Methanothermob...
Feature 1                                
1CLI_A       311 pevdkal--allnangenAWKIGI 332  Escherichia coli
1VK3_A       304 qkasril--eiarkhllfGDVVAE 325  Thermotoga maritima
1T3T_A       566 dqlplfd--elckrerapYAVIGD 587  Salmonella typhimurium
2Z1T_A       281 eraeaalavlregphgehAARIGS 304  Desulfovibrio vulgaris
1T3T_A       942 edrdaveallaqygladcVHYLGQ 965  Salmonella typhimurium
ZP_01574817  277 geglvr----llgennikASIIGT 296  Clostridium cellulolyticum H10
YP_448059    274 ttdetls---llnkahidANCVGK 294  Methanosphaera stadtmanae DSM 3091
P16456       312 eaenevk--ataaefgieLTAIGE 333  Escherichia coli
1VQV_B       271 erw----------npfldXTEIGR 284  Aquifex aeolicus
AAB86000     370 dvapdvm--dtirgagvdVAEIGR 391  Methanothermobacter thermautotrophicus str. Delta H

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