4TS1,1JIJ,1I6M


Conserved Protein Domain Family
Tyr_Trp_RS_core

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cd00395: Tyr_Trp_RS_core 
Click on image for an interactive view with Cn3D
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase
Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Statistics
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PSSM-Id: 173893
View PSSM: cd00395
Aligned: 3 rows
Threshold Bit Score: 333.116
Threshold Setting Gi: 16974813
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1I6M_A; Geobacillus stearothermophilus TrpRS bound to Tryptophanyl-5'AMP using 4.0 A contacts
    View structure with Cn3D
  • Structure:1JIJ_A; Staphylococcus aureus TyrRS binds inhibitor SB-239629 ([2-amino-3-(4-hydroxy-phenyl)-propionylamino]-(1,3,4,5-tetrahydroxy-4-hydroxymethyl-piperidin-2-yl)-acetic acid), defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #####      # ##  # #               #    #                                     
4TS1_A     32 TLYCGFDptadslHIGHLAT-ILTMRRFQQaGHRPIALVGGATGLIgdpsgkksertlnakETVEAWSARIKEQLGRfld 110 Geobacillus stearo...
1JIJ_A     34 TLYCGADptadslHIGHLLP-FLTLRRFQEhGHRPIVLIGGGTGMIgdpsgkseervlqteEQVDKNIEGISKQMHNife 112 Staphylococcus aureus
1I6M_A      3 TIFSGIQpsg-viTIGNYIGaLRQFVELQH-EYNCYFCIVDQHAITvwq----------dpHELRQNIRRLAALYLAvgi 70  Geobacillus stearo...
Feature 1                 #                                               #   #  #            
4TS1_A    111 feadgnpAKIKNNYDWigpldVITFLRdVGKHFSVNYMMAKesvqsri--etgisfTEFSYMMLQAYDFLRLYetegcRL 188 Geobacillus stearo...
1JIJ_A    113 fg-tdhgAVLVNNRDWlgqisLISFLRdYGKHVGVNYMLGKdsiqsrl--ehgisyTEFTYTILQAIDFGHLNrelncKI 189 Staphylococcus aureus
1I6M_A     71 d---ptqATLFIQSEVp---aHAQAAWmLQCIVYIGELERMtqfkeksagkeavsaGLLTYPPLMAADILLYNt----DI 140 Geobacillus stearo...
Feature 1     # ## ##  #                               #         ## #                         
4TS1_A    189 QIGGSDQWGNITAGLELIRktk-----geARAFGLti---pLVTKADGt--KFGKTEsgtiwldkekTSPYEFYQFWInt 258 Geobacillus stearo...
1JIJ_A    190 QVGGSDQWGNITSGIELMRrmy-----gqTDAYGLti---pLVTKSDGk--KFGKSEsgavwldaekTSPYEFYQFWInq 259 Staphylococcus aureus
1I6M_A    141 VPVGEDQKQHIELTRDLAErfnkrygelfTIPEARipkvgaRIMSLVDptkKMSKSDpnpkayitllDDAKTIEKKIKsa 220 Geobacillus stearo...
Feature 1                                                                    
4TS1_A    259 d----------------drDVIRYLKYFtflskeeiealeqelreapekraAQKTLAEEVTKL 305 Geobacillus stearothermophilus
1JIJ_A    260 s----------------deDVIKFLKYFtflgkeeidrleqskneaphlreAQKTLAEEVTKF 306 Staphylococcus aureus
1I6M_A    221 vtdsegtirydkeakpgisNLLNIYSTLsgqsieeler----qyegkgygvFKADLAQVVIET 279 Geobacillus stearothermophilus

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