1PTF,1JEM,1KKM,1MU4,1PCH,1PFH,1RZR,3EZB


Conserved Protein Domain Family
PTS-HPr_like
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cd00367: PTS-HPr_like 
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Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.
Links
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Statistics
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PSSM-Id: 238217
Aligned: 118 rows
Threshold Bit Score: 51.7401
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1PFH: Phosphorylated form of HPr from E.Coli
  • Comment:phosphorylation of this His is part of the phosphotransfer cascade of the PTS
  • Citation:PMID 8421502
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                                     
1PTF        5 EFHIvaetGIHARPATLLVQTASkFNSDINLeyk-----gksVNLKSIMGVMSLGvgqGSDVTITVdg--adEAEGMAAI 77  Enterococcus faecalis
NP_936246   7 VTFLvndvNASAHVAQPLSRVARkFKSTLHIinit---qnrsAELAKSLAVLQVGlqeGDFCQITAig--idAELACFVI 81  Vibrio vulnificus ...
1PFH        5 EVTItapnGLHTRPAAQFVKEAKgFTSEITVtsn-----gksASAKSLFKLQTLGltqGTVVTISAeg--edEQKAVEHL 77  Escherichia coli
P32670      6 EFICelpnGVHARPASHVETLCNtFSSQIEWhnlr---tdrkGNAKSALALIGTDtlaGDNCQLLIsg--adEQEAHQRL 80  Escherichia coli
NP_349688   5 CITVniknGVHTRIAAMIVHEASkLKEKYGInlyvkqmnakePIAISMLALLSLKikeNELVEISCfedttnGQRAVIEL 84  Clostridium acetob...
BAB82064    5 ELIIktplGLHTRYSAMIVNKASeIESKYKVklyikkesytdWLGISMLAILSLKvlpNESILIGSknegmiEKLAVQSL 84  Clostridium perfri...
Q8FFD8      5 QFLCplpnGLHARPAWELKEQCSqWQSEITFinhr---qnakADAKSSLALIGTGtlfNDSCSLNIsg--sdEEQARRVL 79  Escherichia coli O6
AAQ59983    6 TLVCplpnGIHARPASRIAEFCAgFGAAIRWrnqr---ngqlADAKSVLSLIGGDilfNDVVDIEIdg--eeAARVAAEL 80  Chromobacterium vi...
YP_069087   6 TFICglpnGVHARPASHIERVCNrFQSRFHWynpr---sgivGDGKSVLSLIATNillGDECQVTIeg--edEQAAFERL 80  Yersinia pseudotub...
YP_130898   7 TFYCcs-kGLPSYQLHQLKRLADyFRSSVTLlnlr---qlrkADIRQPLRMLSLAskpGELCQLVIqg--ndAELAHMVL 80  Photobacterium pro...

Feature 1         
1PTF       78 VETL 81  Enterococcus faecalis
NP_936246  82 KDML 85  Vibrio vulnificus YJ016
1PFH       78 VKLM 81  Escherichia coli
P32670     81 SQWL 84  Escherichia coli
NP_349688  85 SNYI 88  Clostridium acetobutylicum ATCC 824
BAB82064   85 LEFI 88  Clostridium perfringens str. 13
Q8FFD8     80 EEYI 83  Escherichia coli O6
AAQ59983   81 GRFL 84  Chromobacterium violaceum ATCC 12472
YP_069087  81 SIFI 84  Yersinia pseudotuberculosis IP 32953
YP_130898  81 TEFI 84  Photobacterium profundum SS9

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